Linking amyloid to clinical outcome: A quantitative semi‐mechanistic model based on the A/T/N biomarker framework to simulate the natural history of Alzheimer’s disease and the effects of anti‐amyloid treatment

Background According to FDA’s literature review of clinical trial data from a number of anti‐amyloid antibodies, a “clear relationship” was demonstrated between the extent of amyloid plaque removal measured by amyloid PET and the magnitude of clinical benefit measured by the placebo‐corrected differ...

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Veröffentlicht in:	Alzheimer's & dementia 2022-12, Vol.18 (S3), p.n/a
Hauptverfasser:	Mazer, Norman A, Hofmann, Carsten, Lott, Dominik, Gieschke, Ronald, Klein, Gregory, Boess, Frank, Grimm, Hans Peter, Kerchner, Geoffrey A., Baudler, Monika, Smith, Janice, Schobel, Scott, Doody, Rachelle S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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