G protein‐biased GPR3 signaling induces glial activation and ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model

Background Biased G protein‐coupled receptor (GPCR) ligands preferentially activate G protein‐ or β‐arrestin signaling pathways and are leading to the development of drugs with superior efficacy and reduced side‐effects in heart disease, pain management, and neuropsychiatric disorders. Although GPCR...

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Veröffentlicht in:	Alzheimer's & dementia 2023-06, Vol.19 (S1), p.n/a
Hauptverfasser:	Thathiah, Amantha, Huang, Yunhong, Guimaraes, Thais Rafael, Todd, Nicholas, Ferguson, Carolyn, Weiss, Kathryn, Stauffer, Fiona, McDermott, Breanne, Hurtle, Bryan T., Saito, Takashi, Saido, Takaomi, MacDonald, Matthew L, Farris, Sean P., Homanics, Gregg E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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