Exploring lysosomal defects and rescue strategies for Alzheimer’s disease using human transdifferentiated neurons

Background Aging is the critical factor of Alzheimer’s disease (AD), the most common neurodegenerative disease. Among the pathological changes in the brain associated with AD, protein aggregates are the characteristic pathological hallmark that is composed of misfolded and toxic proteins. A decline...

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Veröffentlicht in:	Alzheimer's & dementia 2022-12, Vol.18 (S4), p.n/a
Hauptverfasser:	Chou, Ching‐Chieh, Vest, Ryan, Shibuya, Yohei, Prado, Miguel A, Wilson‐Grady, Joshua, Greicius, Michael D, Finley, Daniel, Wernig, Marius, Wyss‐Coray, Tony, Frydman, Judith
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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