WVE‐005, a stereopure antisense oligonucleotide for MAPT silencing in tauopathies

Background: Tau is a neuronal scaffolding protein which aggregates intracellularly upon hyperphosphorylation to form neurofibrillary tangles (NFT). NFTs are a hallmark of various microtubule associated protein tau (MAPT)‐associated neurodegenerative diseases, including Alzheimer’s disease, frontotem...

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Veröffentlicht in:	Alzheimer's & dementia 2022-12, Vol.18 (S10), p.n/a
Hauptverfasser:	DaleMaguire, ElenaAbbie, Guo, Lankai, Byrne, Michael, Cannon, Megan, Taborn, Kris, Prakasha, Priyanka Shiva, Longo, Kenneth, Iwamoto, Naoki, Kandasamy, Pachamuthu, Shimizu, Mamoru, Shum, Pochi, Ranade, Ashwini, Iyer, Raghuvaran, Bowman, Keith, Yang, Hailin, Yin, Yuan Benny, Liu, Fangjun, Mohapatra, Susovan, Macovei, Lilia, Patil, Saurabh, Lansita, Janice, Hu, Xiao Shelley, Smith, Karen, Goyal, Jaya, Narayanan, Padma, Rhodes, Ken, Panzara, Michael, Vargeese, Chandra
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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