Choanal atresia associated with prenatal methimazole exposure: Three new patients

We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in ute...

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Veröffentlicht in:American journal of medical genetics. Part A 2004-08, Vol.129A (1), p.83-86
Hauptverfasser: Barbero, P., Ricagni, C., Mercado, G., Bronberg, R., Torrado, M.
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container_end_page 86
container_issue 1
container_start_page 83
container_title American journal of medical genetics. Part A
container_volume 129A
creator Barbero, P.
Ricagni, C.
Mercado, G.
Bronberg, R.
Torrado, M.
description We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. © 2004 Wiley‐Liss, Inc.
doi_str_mv 10.1002/ajmg.a.20668
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subjects Antithyroid Agents - adverse effects
Antithyroid Agents - therapeutic use
choanal atresia
Choanal Atresia - chemically induced
embryopathy
Female
Humans
Infant
Infant, Newborn
methimazole
Methimazole - adverse effects
Methimazole - therapeutic use
Pregnancy
Pregnancy Complications - drug therapy
Prenatal Exposure Delayed Effects
teratology
Thyrotoxicosis - drug therapy
title Choanal atresia associated with prenatal methimazole exposure: Three new patients
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