Choanal atresia associated with prenatal methimazole exposure: Three new patients
We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in ute...
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Veröffentlicht in: | American journal of medical genetics. Part A 2004-08, Vol.129A (1), p.83-86 |
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container_title | American journal of medical genetics. Part A |
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creator | Barbero, P. Ricagni, C. Mercado, G. Bronberg, R. Torrado, M. |
description | We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. © 2004 Wiley‐Liss, Inc. |
doi_str_mv | 10.1002/ajmg.a.20668 |
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The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4825</identifier><identifier>EISSN: 1552-4833</identifier><identifier>DOI: 10.1002/ajmg.a.20668</identifier><identifier>PMID: 15266622</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antithyroid Agents - adverse effects ; Antithyroid Agents - therapeutic use ; choanal atresia ; Choanal Atresia - chemically induced ; embryopathy ; Female ; Humans ; Infant ; Infant, Newborn ; methimazole ; Methimazole - adverse effects ; Methimazole - therapeutic use ; Pregnancy ; Pregnancy Complications - drug therapy ; Prenatal Exposure Delayed Effects ; teratology ; Thyrotoxicosis - drug therapy</subject><ispartof>American journal of medical genetics. 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Part A</title><addtitle>Am J Med Genet A</addtitle><description>We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. © 2004 Wiley‐Liss, Inc.</description><subject>Antithyroid Agents - adverse effects</subject><subject>Antithyroid Agents - therapeutic use</subject><subject>choanal atresia</subject><subject>Choanal Atresia - chemically induced</subject><subject>embryopathy</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>methimazole</subject><subject>Methimazole - adverse effects</subject><subject>Methimazole - therapeutic use</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - drug therapy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>teratology</subject><subject>Thyrotoxicosis - drug therapy</subject><issn>1552-4825</issn><issn>1552-4833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQQBdRbK3ePMv-AFP3I7vZeitFq1IRoZ6XSTIxKfliN6XWX29qRG-eZhgej-ERcsnZlDMmbmBTvU9hKpjW5oiMuVIiCI2Ux7-7UCNy5v2GMclUpE_JiCuhtRZiTF4XeQM1lBQ6h74ACt43SQEdpnRXdDltHdbQ9UCFXV5U8NmUSPGjbfzW4S1d5w6R1rijLXQF1p0_JycZlB4vfuaEvN3frRcPwepl-biYr4JESm4CAamQMtHhTEoGWayMmBlkKhFRzEPURmGsIhbzLDLhLGOhiTmkmWL9OQ6NlhNyPXgT13jvMLOt6_9ze8uZPZSxhzIW7HeZHr8a8HYbV5j-wT8pekAOwK4ocf-vzM6fnpeD9gsGrnA1</recordid><startdate>20040815</startdate><enddate>20040815</enddate><creator>Barbero, P.</creator><creator>Ricagni, C.</creator><creator>Mercado, G.</creator><creator>Bronberg, R.</creator><creator>Torrado, M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040815</creationdate><title>Choanal atresia associated with prenatal methimazole exposure: Three new patients</title><author>Barbero, P. ; Ricagni, C. ; Mercado, G. ; Bronberg, R. ; Torrado, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3318-2ad233c649330afb58298e05c27b14e685eb570b1f7849f048b1adf50eb5b4863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antithyroid Agents - adverse effects</topic><topic>Antithyroid Agents - therapeutic use</topic><topic>choanal atresia</topic><topic>Choanal Atresia - chemically induced</topic><topic>embryopathy</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>methimazole</topic><topic>Methimazole - adverse effects</topic><topic>Methimazole - therapeutic use</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - drug therapy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>teratology</topic><topic>Thyrotoxicosis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbero, P.</creatorcontrib><creatorcontrib>Ricagni, C.</creatorcontrib><creatorcontrib>Mercado, G.</creatorcontrib><creatorcontrib>Bronberg, R.</creatorcontrib><creatorcontrib>Torrado, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>American journal of medical genetics. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbero, P.</au><au>Ricagni, C.</au><au>Mercado, G.</au><au>Bronberg, R.</au><au>Torrado, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Choanal atresia associated with prenatal methimazole exposure: Three new patients</atitle><jtitle>American journal of medical genetics. Part A</jtitle><addtitle>Am J Med Genet A</addtitle><date>2004-08-15</date><risdate>2004</risdate><volume>129A</volume><issue>1</issue><spage>83</spage><epage>86</epage><pages>83-86</pages><issn>1552-4825</issn><eissn>1552-4833</eissn><abstract>We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15266622</pmid><doi>10.1002/ajmg.a.20668</doi><tpages>4</tpages></addata></record> |
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subjects | Antithyroid Agents - adverse effects Antithyroid Agents - therapeutic use choanal atresia Choanal Atresia - chemically induced embryopathy Female Humans Infant Infant, Newborn methimazole Methimazole - adverse effects Methimazole - therapeutic use Pregnancy Pregnancy Complications - drug therapy Prenatal Exposure Delayed Effects teratology Thyrotoxicosis - drug therapy |
title | Choanal atresia associated with prenatal methimazole exposure: Three new patients |
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