Expression of class μ glutathione-S-transferase in human liver and its association with hepatopathies
We studied the distribution of GSTM1 phenotypes in 611 individuals from an ethnically mixed sample of the Brazilian population who died from various causes. No influence of age, gender, or ethnicity was detected on the phenotypic distribution. In a sub‐sample of 66 alcoholic individuals compared wit...
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| Veröffentlicht in: | American journal of medical genetics 2003-12, Vol.123A (3), p.257-260 |
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| container_title | American journal of medical genetics |
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| creator | Engracia, V. Leite, M.M.B.S. Pagotto, R.C. Zucoloto, S. Barbosa, C.A.A. Mestriner, M.A. |
| description | We studied the distribution of GSTM1 phenotypes in 611 individuals from an ethnically mixed sample of the Brazilian population who died from various causes. No influence of age, gender, or ethnicity was detected on the phenotypic distribution. In a sub‐sample of 66 alcoholic individuals compared with 399 non‐alcoholics there was almost a doubling of the odds ratio for GSTM1(0) individuals in the alcoholic category. The incidence of hepatopathies was higher in this group as well, and we observed a significant association of the null phenotype with cirrhosis. An excess of null phenotypes (374/611) was observed, and the allelic distribution was: GSTM1*A = 0.168, *B = 0.089, and *0 (null) = 0.743. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.a.20364 |
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No influence of age, gender, or ethnicity was detected on the phenotypic distribution. In a sub‐sample of 66 alcoholic individuals compared with 399 non‐alcoholics there was almost a doubling of the odds ratio for GSTM1(0) individuals in the alcoholic category. The incidence of hepatopathies was higher in this group as well, and we observed a significant association of the null phenotype with cirrhosis. An excess of null phenotypes (374/611) was observed, and the allelic distribution was: GSTM1*A = 0.168, *B = 0.089, and *0 (null) = 0.743. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4825</identifier><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1552-4833</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/ajmg.a.20364</identifier><identifier>PMID: 14608647</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Alcoholism - enzymology ; Alcoholism - ethnology ; Alcoholism - genetics ; Biological and medical sciences ; Brazil ; Brazilian population ; disease association ; Female ; Gene Expression Regulation, Enzymologic ; Gene Frequency ; General aspects. Genetic counseling ; Genetic Predisposition to Disease - genetics ; Genotype ; Glutathione Transferase - genetics ; Glutathione Transferase - metabolism ; GSTM1 ; human liver ; Humans ; Liver - enzymology ; Liver - metabolism ; Liver Diseases - enzymology ; Liver Diseases - ethnology ; Liver Diseases - genetics ; Male ; Medical genetics ; Medical sciences ; Odds Ratio ; Phenotype</subject><ispartof>American journal of medical genetics, 2003-12, Vol.123A (3), p.257-260</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4304-532df365d654f21f33acf1ac857d0cf1516e57ca3a7fca498443f4a88f74a84b3</citedby><cites>FETCH-LOGICAL-c4304-532df365d654f21f33acf1ac857d0cf1516e57ca3a7fca498443f4a88f74a84b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajmg.a.20364$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajmg.a.20364$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15296932$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14608647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engracia, V.</creatorcontrib><creatorcontrib>Leite, M.M.B.S.</creatorcontrib><creatorcontrib>Pagotto, R.C.</creatorcontrib><creatorcontrib>Zucoloto, S.</creatorcontrib><creatorcontrib>Barbosa, C.A.A.</creatorcontrib><creatorcontrib>Mestriner, M.A.</creatorcontrib><title>Expression of class μ glutathione-S-transferase in human liver and its association with hepatopathies</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>We studied the distribution of GSTM1 phenotypes in 611 individuals from an ethnically mixed sample of the Brazilian population who died from various causes. No influence of age, gender, or ethnicity was detected on the phenotypic distribution. In a sub‐sample of 66 alcoholic individuals compared with 399 non‐alcoholics there was almost a doubling of the odds ratio for GSTM1(0) individuals in the alcoholic category. The incidence of hepatopathies was higher in this group as well, and we observed a significant association of the null phenotype with cirrhosis. An excess of null phenotypes (374/611) was observed, and the allelic distribution was: GSTM1*A = 0.168, *B = 0.089, and *0 (null) = 0.743. © 2003 Wiley‐Liss, Inc.</description><subject>Alcoholism - enzymology</subject><subject>Alcoholism - ethnology</subject><subject>Alcoholism - genetics</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Brazilian population</subject><subject>disease association</subject><subject>Female</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Frequency</subject><subject>General aspects. Genetic counseling</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Glutathione Transferase - metabolism</subject><subject>GSTM1</subject><subject>human liver</subject><subject>Humans</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Liver Diseases - enzymology</subject><subject>Liver Diseases - ethnology</subject><subject>Liver Diseases - genetics</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Phenotype</subject><issn>1552-4825</issn><issn>0148-7299</issn><issn>1552-4833</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMluFDEQhi0EIgvcOCNf4EQP3rvnmERhSJSARNhuVsVtZxx6w9Wd5d14hjxTPMyQ3LjYpdL3_yV9hLzibMYZE-_hsr2YwUwwadQTss21FoWqpHz6MAu9RXYQLxmTTJfmOdniyrDKqHKbhMObIXnE2He0D9Q1gEjv_tCLZhphXOa1L86KMUGHwSdAT2NHl1MLHW3ilU8UuprGEWnO9S7CuCq6juOSLv0AYz-sSjy-IM8CNOhfbv5d8u3D4deDj8XJ58XRwd5J4ZRkqtBS1EEaXRutguBBSnCBg6t0WbM8aW68Lh1IKIMDNa-UkkFBVYUyv-pc7pK3694h9b8nj6NtIzrfNND5fkLL50poI3kG361Bl3rE5IMdUmwh3VrO7MqrXXm1YP96zfjrTe903vr6Ed6IzMCbDQDooAlZmIv4yGkxN3MpMifX3HVs_O1_j9q949PFv_PFOhVx9DcPKUi_rCllqe2PTwsrxZef-vvpmd2X9848onY</recordid><startdate>20031215</startdate><enddate>20031215</enddate><creator>Engracia, V.</creator><creator>Leite, M.M.B.S.</creator><creator>Pagotto, R.C.</creator><creator>Zucoloto, S.</creator><creator>Barbosa, C.A.A.</creator><creator>Mestriner, M.A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20031215</creationdate><title>Expression of class μ glutathione-S-transferase in human liver and its association with hepatopathies</title><author>Engracia, V. ; Leite, M.M.B.S. ; Pagotto, R.C. ; Zucoloto, S. ; Barbosa, C.A.A. ; Mestriner, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4304-532df365d654f21f33acf1ac857d0cf1516e57ca3a7fca498443f4a88f74a84b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alcoholism - enzymology</topic><topic>Alcoholism - ethnology</topic><topic>Alcoholism - genetics</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Brazilian population</topic><topic>disease association</topic><topic>Female</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Frequency</topic><topic>General aspects. Genetic counseling</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Glutathione Transferase - metabolism</topic><topic>GSTM1</topic><topic>human liver</topic><topic>Humans</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Liver Diseases - enzymology</topic><topic>Liver Diseases - ethnology</topic><topic>Liver Diseases - genetics</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engracia, V.</creatorcontrib><creatorcontrib>Leite, M.M.B.S.</creatorcontrib><creatorcontrib>Pagotto, R.C.</creatorcontrib><creatorcontrib>Zucoloto, S.</creatorcontrib><creatorcontrib>Barbosa, C.A.A.</creatorcontrib><creatorcontrib>Mestriner, M.A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>American journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engracia, V.</au><au>Leite, M.M.B.S.</au><au>Pagotto, R.C.</au><au>Zucoloto, S.</au><au>Barbosa, C.A.A.</au><au>Mestriner, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of class μ glutathione-S-transferase in human liver and its association with hepatopathies</atitle><jtitle>American journal of medical genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2003-12-15</date><risdate>2003</risdate><volume>123A</volume><issue>3</issue><spage>257</spage><epage>260</epage><pages>257-260</pages><issn>1552-4825</issn><issn>0148-7299</issn><eissn>1552-4833</eissn><eissn>1096-8628</eissn><coden>AJMGDA</coden><abstract>We studied the distribution of GSTM1 phenotypes in 611 individuals from an ethnically mixed sample of the Brazilian population who died from various causes. No influence of age, gender, or ethnicity was detected on the phenotypic distribution. In a sub‐sample of 66 alcoholic individuals compared with 399 non‐alcoholics there was almost a doubling of the odds ratio for GSTM1(0) individuals in the alcoholic category. The incidence of hepatopathies was higher in this group as well, and we observed a significant association of the null phenotype with cirrhosis. 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| subjects | Alcoholism - enzymology Alcoholism - ethnology Alcoholism - genetics Biological and medical sciences Brazil Brazilian population disease association Female Gene Expression Regulation, Enzymologic Gene Frequency General aspects. Genetic counseling Genetic Predisposition to Disease - genetics Genotype Glutathione Transferase - genetics Glutathione Transferase - metabolism GSTM1 human liver Humans Liver - enzymology Liver - metabolism Liver Diseases - enzymology Liver Diseases - ethnology Liver Diseases - genetics Male Medical genetics Medical sciences Odds Ratio Phenotype |
| title | Expression of class μ glutathione-S-transferase in human liver and its association with hepatopathies |
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