$Sequential intermediate‐dose cytosine arabinoside and mitoxantrone for patients with relapsed and refractory acute myelocytic leukemia$

Sequential intermediate‐dose cytosine arabinoside and mitoxantrone for patients with relapsed and refractory acute myelocytic leukemia

Based on in vitro evidence of time‐dependent synergistic kill of HL‐60 leukemia cells exposed to Ara‐C and mitoxantrone, 44 patients with relapsed or refractory AML and 3 with blastic CML were treated with a timed sequence of both drugs. There were 25 females and 22 males, with a median age of 53 (r...

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Veröffentlicht in:	American journal of hematology 1990-09, Vol.35 (1), p.22-25
Hauptverfasser:	Paciucci, Paolo Alberto, Cuttner, Janet, Holland, James F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Ara‐C Biological and medical sciences Chemotherapy Clinical Trials as Topic Cytarabine - administration & dosage Cytarabine - adverse effects Cytarabine - therapeutic use Delayed-Action Preparations Female Humans Leukemia, Myeloid, Acute - drug therapy Male Medical sciences Middle Aged mitoxantrone Mitoxantrone - administration & dosage Mitoxantrone - adverse effects Mitoxantrone - therapeutic use Pharmacology. Drug treatments Pilot Projects Recurrence refractory AML Remission Induction Time Factors
Online-Zugang:	Volltext
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