Oral decitabine reactivates expression of the methylated γ‐globin gene in Papio anubis

The silencing of tumor suppressor genes associated with increased DNA methylation of the promoter regions is a frequent observation in many forms of cancer. Reactivation of these genes using pharmacological inhibitors of DNA methyltransferase such as 5‐aza‐2′‐deoxycytidine (decitabine) is a worthwhi...

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