Acute biphenotypic leukemia arising in a patient with essential thrombocythemia

Acute leukemia is an uncommon complication of patients with essential thrombocythemia (ET). We describe a patient with ET, who transformed to acute biphenotypic leukemia 4 and 1/2 years after initial ET diagnosis. She had received hydroxyurea, anagrelide, and interferon, in different combinations an...

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Veröffentlicht in:	American journal of hematology 2006-08, Vol.81 (8), p.624-626
Hauptverfasser:	Wong, Gee Chuan, Lee, Lai Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	acute biphenotypic leukemia Acute Disease anagrelide Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Chromosome Aberrations Chromosomes, Human, Pair 20 - genetics Cytogenetic Analysis essential thrombocythemia Female Follow-Up Studies Hematologic and hematopoietic diseases Humans hydroxyurea Hydroxyurea - adverse effects Hydroxyurea - therapeutic use interferon Leukemia - complications Leukemia - drug therapy Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Platelet diseases and coagulopathies Quinazolines - adverse effects Quinazolines - therapeutic use Remission Induction Thrombocythemia, Essential - complications Thrombocythemia, Essential - diagnosis Thrombocythemia, Essential - drug therapy transformation Treatment Outcome
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