Acute biphenotypic leukemia arising in a patient with essential thrombocythemia
Acute leukemia is an uncommon complication of patients with essential thrombocythemia (ET). We describe a patient with ET, who transformed to acute biphenotypic leukemia 4 and 1/2 years after initial ET diagnosis. She had received hydroxyurea, anagrelide, and interferon, in different combinations an...
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| Veröffentlicht in: | American journal of hematology 2006-08, Vol.81 (8), p.624-626 |
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| creator | Wong, Gee Chuan Lee, Lai Heng |
| description | Acute leukemia is an uncommon complication of patients with essential thrombocythemia (ET). We describe a patient with ET, who transformed to acute biphenotypic leukemia 4 and 1/2 years after initial ET diagnosis. She had received hydroxyurea, anagrelide, and interferon, in different combinations and varying doses, before leukemic transformation. Acute biphenotypic leukemia was confirmed on bone marrow studies and immunophenotyping. Complete remission (CR) was achieved with induction chemotherapy for acute leukemia. This was followed with consolidation chemotherapy and the patient has remained in CR 9 months after initial induction chemotherapy. To our knowledge, this is a rare event of acute biphenotypic leukemic transformation of a patient with ET. Am. J. Hematol. 81:624–626, 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.20651 |
| format | Article |
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We describe a patient with ET, who transformed to acute biphenotypic leukemia 4 and 1/2 years after initial ET diagnosis. She had received hydroxyurea, anagrelide, and interferon, in different combinations and varying doses, before leukemic transformation. Acute biphenotypic leukemia was confirmed on bone marrow studies and immunophenotyping. Complete remission (CR) was achieved with induction chemotherapy for acute leukemia. This was followed with consolidation chemotherapy and the patient has remained in CR 9 months after initial induction chemotherapy. To our knowledge, this is a rare event of acute biphenotypic leukemic transformation of a patient with ET. Am. J. Hematol. 81:624–626, 2006. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.20651</identifier><identifier>PMID: 16823822</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>acute biphenotypic leukemia ; Acute Disease ; anagrelide ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Biological and medical sciences ; Chromosome Aberrations ; Chromosomes, Human, Pair 20 - genetics ; Cytogenetic Analysis ; essential thrombocythemia ; Female ; Follow-Up Studies ; Hematologic and hematopoietic diseases ; Humans ; hydroxyurea ; Hydroxyurea - adverse effects ; Hydroxyurea - therapeutic use ; interferon ; Leukemia - complications ; Leukemia - drug therapy ; Leukemia - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Middle Aged ; Platelet diseases and coagulopathies ; Quinazolines - adverse effects ; Quinazolines - therapeutic use ; Remission Induction ; Thrombocythemia, Essential - complications ; Thrombocythemia, Essential - diagnosis ; Thrombocythemia, Essential - drug therapy ; transformation ; Treatment Outcome</subject><ispartof>American journal of hematology, 2006-08, Vol.81 (8), p.624-626</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-318a672f7007a0773879f44d7a2db7aa12a7fc1db76d1771cedaf3e886e7fc0e3</citedby><cites>FETCH-LOGICAL-c3881-318a672f7007a0773879f44d7a2db7aa12a7fc1db76d1771cedaf3e886e7fc0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.20651$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.20651$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17953334$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16823822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Gee Chuan</creatorcontrib><creatorcontrib>Lee, Lai Heng</creatorcontrib><title>Acute biphenotypic leukemia arising in a patient with essential thrombocythemia</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Acute leukemia is an uncommon complication of patients with essential thrombocythemia (ET). We describe a patient with ET, who transformed to acute biphenotypic leukemia 4 and 1/2 years after initial ET diagnosis. She had received hydroxyurea, anagrelide, and interferon, in different combinations and varying doses, before leukemic transformation. Acute biphenotypic leukemia was confirmed on bone marrow studies and immunophenotyping. Complete remission (CR) was achieved with induction chemotherapy for acute leukemia. This was followed with consolidation chemotherapy and the patient has remained in CR 9 months after initial induction chemotherapy. To our knowledge, this is a rare event of acute biphenotypic leukemic transformation of a patient with ET. Am. J. Hematol. 81:624–626, 2006. © 2006 Wiley‐Liss, Inc.</description><subject>acute biphenotypic leukemia</subject><subject>Acute Disease</subject><subject>anagrelide</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 20 - genetics</subject><subject>Cytogenetic Analysis</subject><subject>essential thrombocythemia</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>hydroxyurea</subject><subject>Hydroxyurea - adverse effects</subject><subject>Hydroxyurea - therapeutic use</subject><subject>interferon</subject><subject>Leukemia - complications</subject><subject>Leukemia - drug therapy</subject><subject>Leukemia - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet diseases and coagulopathies</subject><subject>Quinazolines - adverse effects</subject><subject>Quinazolines - therapeutic use</subject><subject>Remission Induction</subject><subject>Thrombocythemia, Essential - complications</subject><subject>Thrombocythemia, Essential - diagnosis</subject><subject>Thrombocythemia, Essential - drug therapy</subject><subject>transformation</subject><subject>Treatment Outcome</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqUw8AeQFwaGtP5IbWesEFBQpS4wRxfHIS75kp2qyr_HJZU6Md2r03P3Sg9C95TMKSFsAbtyzohY0gs0pSQRkRJLdommhAsaMkkm6Mb7HSGUxopcowkVinHF2BRtV3rfG5zZrjRN2w-d1bgy-x9TW8DgrLfNN7YNBtxBb03T44PtS2y8D9lChfvStXXW6qEvjze36KqAypu705yhr9eXz-d1tNm-vT-vNpHmStGIUwVCskISIoFIyZVMijjOJbA8kwCUgSw0DVnkVEqqTQ4FN0oJE_bE8Bl6Gv9q13rvTJF2ztbghpSS9CglDVLSPymBfRjZbp_VJj-TJwsBeDwB4DVUhYNGW3_mZLLknMeBW4zcwVZm-L8xXX2sx-pfCx15XA</recordid><startdate>200608</startdate><enddate>200608</enddate><creator>Wong, Gee Chuan</creator><creator>Lee, Lai Heng</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200608</creationdate><title>Acute biphenotypic leukemia arising in a patient with essential thrombocythemia</title><author>Wong, Gee Chuan ; Lee, Lai Heng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-318a672f7007a0773879f44d7a2db7aa12a7fc1db76d1771cedaf3e886e7fc0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>acute biphenotypic leukemia</topic><topic>Acute Disease</topic><topic>anagrelide</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 20 - genetics</topic><topic>Cytogenetic Analysis</topic><topic>essential thrombocythemia</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>hydroxyurea</topic><topic>Hydroxyurea - adverse effects</topic><topic>Hydroxyurea - therapeutic use</topic><topic>interferon</topic><topic>Leukemia - complications</topic><topic>Leukemia - drug therapy</topic><topic>Leukemia - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet diseases and coagulopathies</topic><topic>Quinazolines - adverse effects</topic><topic>Quinazolines - therapeutic use</topic><topic>Remission Induction</topic><topic>Thrombocythemia, Essential - complications</topic><topic>Thrombocythemia, Essential - diagnosis</topic><topic>Thrombocythemia, Essential - drug therapy</topic><topic>transformation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Gee Chuan</creatorcontrib><creatorcontrib>Lee, Lai Heng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Gee Chuan</au><au>Lee, Lai Heng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute biphenotypic leukemia arising in a patient with essential thrombocythemia</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2006-08</date><risdate>2006</risdate><volume>81</volume><issue>8</issue><spage>624</spage><epage>626</epage><pages>624-626</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Acute leukemia is an uncommon complication of patients with essential thrombocythemia (ET). We describe a patient with ET, who transformed to acute biphenotypic leukemia 4 and 1/2 years after initial ET diagnosis. She had received hydroxyurea, anagrelide, and interferon, in different combinations and varying doses, before leukemic transformation. Acute biphenotypic leukemia was confirmed on bone marrow studies and immunophenotyping. Complete remission (CR) was achieved with induction chemotherapy for acute leukemia. This was followed with consolidation chemotherapy and the patient has remained in CR 9 months after initial induction chemotherapy. To our knowledge, this is a rare event of acute biphenotypic leukemic transformation of a patient with ET. Am. J. Hematol. 81:624–626, 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16823822</pmid><doi>10.1002/ajh.20651</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | acute biphenotypic leukemia Acute Disease anagrelide Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Chromosome Aberrations Chromosomes, Human, Pair 20 - genetics Cytogenetic Analysis essential thrombocythemia Female Follow-Up Studies Hematologic and hematopoietic diseases Humans hydroxyurea Hydroxyurea - adverse effects Hydroxyurea - therapeutic use interferon Leukemia - complications Leukemia - drug therapy Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Platelet diseases and coagulopathies Quinazolines - adverse effects Quinazolines - therapeutic use Remission Induction Thrombocythemia, Essential - complications Thrombocythemia, Essential - diagnosis Thrombocythemia, Essential - drug therapy transformation Treatment Outcome |
| title | Acute biphenotypic leukemia arising in a patient with essential thrombocythemia |
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