Prognostic significance of the F‐box protein Skp2 expression in diffuse large B‐cell lymphoma

The F‐box protein Skp2 positively regulates the G1‐S transition by promoting degradation of the cyclin‐dependent kinase inhibitor p27kip1 (p27). Recent evidence has suggested an oncogenic role of Skp2 in not only carcinogenesis but also lymphomagenesis. In this study, we performed immunohistochemica...

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Veröffentlicht in:	American journal of hematology 2003-08, Vol.73 (4), p.230-235
Hauptverfasser:	Seki, Ritsuko, Okamura, Takashi, Koga, Hironori, Yakushiji, Kazuaki, Hashiguchi, Michitoshi, Yoshimoto, Kohji, Ogata, Hideaki, Imamura, Rie, Nakashima, Yutaka, Kage, Masayoshi, Ueno, Takato, Sata, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Biomarkers - analysis cell cycle Cell Cycle Proteins - analysis Female Hematologic and hematopoietic diseases Humans Immunohistochemistry Ki-67 Antigen - analysis Ki‐67 Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - mortality Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Male Medical sciences Middle Aged p27 Prognosis prognostic factor Proliferating Cell Nuclear Antigen - analysis S-Phase Kinase-Associated Proteins Survival Analysis Treatment Outcome ubiquitin ligase
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