Engineering 2‐oxoglutarate dehydrogenase to a 2‐oxo aliphatic dehydrogenase complex by optimizing consecutive components

Multienzyme complexes have the potential for green catalysis of sequential reactions. The Escherichia coli 2‐oxoglutarate dehydrogenase complex (OGDHc) was converted from a 2‐oxoglutarate dehydrogenase to a 2‐oxo aliphatic dehydrogenase complex by engineering consecutive components. OGDHc catalyzes...

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Veröffentlicht in:	AIChE journal 2020-03, Vol.66 (3), p.n/a, Article 16769
Hauptverfasser:	Chakraborty, Joydeep, Nemeria, Natalia S., Zhang, Xu, Nareddy, Pradeep R., Szostak, Michal, Farinas, Edgardo, Jordan, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Catalysis Chemical synthesis Dehydrogenase Dehydrogenases directed evolution E coli Engineering Engineering, Chemical green chemistry Krebs cycle multienzyme complex Multienzyme complexes protein engineering Saturation mutagenesis Science & Technology Substrates Technology thioester synthesis Tricarboxylic acid cycle
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