Id1 and Id3 Are Regulated Through Matrix‐Assisted Autocrine BMP Signaling and Represent Therapeutic Targets in Melanoma

The tumorigenicity of cancer cells is highly influenced by the extracellular matrix (ECM) through mechanisms that are poorly understood. Here it is reported that a variety of 3D ECM microenvironments strongly induce expression of Id1 and Id3 in melanoma cells. Genetic ablation of Id1/Id3 impairs mel...

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Veröffentlicht in:	Advanced therapeutics 2021-02, Vol.4 (2), p.n/a
Hauptverfasser:	Sedlmeier, Georg, Al‐Rawi, Vanessa, Buchert, Justyna, Yserentant, Klaus, Rothley, Melanie, Steshina, Anastasia, Gräßle, Simone, Wu, Ruo‐Lin, Hurrle, Thomas, Richer, Wilfrid, Decraene, Charles, Thiele, Wilko, Utikal, Jochen, Abuillan, Wasim, Tanaka, Motomu, Herten, Dirk‐Peter, Hill, Caroline S., Garvalov, Boyan K., Jung, Nicole, Bräse, Stefan, Sleeman, Jonathan P.
Format:	Artikel
Sprache:	eng
Schlagworte:	bone morphogenetic proteins coumarin derivatives DNA binding inhibitors extracellular matrix melanoma
Online-Zugang:	Volltext
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