Synthesis of Anilides by Aminolysis of Unactivated Esters using MnCl 2 in Combination with strong Bases as Catalyst
Anilides are often found in pharmaceuticals and active ingredients in crop protection. Although of great interest, the atom‐ and step economic formation of the amide bond between a less nucleophilic aniline with an acid or ester remains still a major challenge. Herein, we report an aminolysis of aro...
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| Veröffentlicht in: | Advanced synthesis & catalysis 2023-06, Vol.365 (11), p.1794-1800 |
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| container_issue | 11 |
| container_start_page | 1794 |
| container_title | Advanced synthesis & catalysis |
| container_volume | 365 |
| creator | Niggli, Nadja E. Vollgraff, Tobias Winter, Christian Slavcheva Petkova, Desislava Benson, Stefan Götz, Roland Hashmi, A. Stephen K. Schaub, Thomas |
| description | Anilides are often found in pharmaceuticals and active ingredients in crop protection. Although of great interest, the atom‐ and step economic formation of the amide bond between a less nucleophilic aniline with an acid or ester remains still a major challenge. Herein, we report an aminolysis of aromatic and alkyl esters with anilines catalyzed by a readily available catalytic system comprising of an earth‐abundant Mn‐salt in combination with an inexpensive base. |
| doi_str_mv | 10.1002/adsc.202300285 |
| format | Article |
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| ispartof | Advanced synthesis & catalysis, 2023-06, Vol.365 (11), p.1794-1800 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1002_adsc_202300285 |
| source | Wiley Online Library Journals Frontfile Complete |
| title | Synthesis of Anilides by Aminolysis of Unactivated Esters using MnCl 2 in Combination with strong Bases as Catalyst |
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