A Continuous‐Flow Method for the Transformation from Amides to Nitriles Catalyzed by CeO 2 in Acetonitrile

A Continuous‐Flow Method for the Transformation from Amides to Nitriles Catalyzed by CeO 2 in Acetonitrile

A CeO 2 ‐catalyzed method for the transformation from amides to nitriles was developed using acetonitrile as the solvent and dehydrating reagent. The transformation proceeded via a formal “water transfer” reaction between the amides and acetonitrile. We propose that the presence of oxygen defect sit...

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Veröffentlicht in:Advanced synthesis & catalysis 2023-05, Vol.365 (10), p.1618-1622
Hauptverfasser: Kobayashi, Kwihwan, Masuda, Koichiro, Feng, Fei, Rashed, Md. Nurnobi, Sato, Kazuhiko, Koumura, Nagatoshi, Kobayashi, Shū
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container_end_page 1622
container_issue 10
container_start_page 1618
container_title Advanced synthesis & catalysis
container_volume 365
creator Kobayashi, Kwihwan
Masuda, Koichiro
Feng, Fei
Rashed, Md. Nurnobi
Sato, Kazuhiko
Koumura, Nagatoshi
Kobayashi, Shū
description A CeO 2 ‐catalyzed method for the transformation from amides to nitriles was developed using acetonitrile as the solvent and dehydrating reagent. The transformation proceeded via a formal “water transfer” reaction between the amides and acetonitrile. We propose that the presence of oxygen defect sites in CeO 2 is important in the mechanism of this transformation. Various nitriles could be continuously synthesized from amides in 75–96% yields via flow operation using a catalyst column packed with CeO 2 .
doi_str_mv 10.1002/adsc.202300266
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title A Continuous‐Flow Method for the Transformation from Amides to Nitriles Catalyzed by CeO 2 in Acetonitrile
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