Asymmetric Amination of α‐Chiral Aliphatic Aldehydes via Dynamic Kinetic Resolution to Access Stereocomplementary Brivaracetam and Pregabalin Precursors

Over the last decades biocatalysis has emerged as an indispensable and versatile tool for the asymmetric synthesis of active pharmaceutical ingredients (APIs). In this context, especially transaminases (TAs) have been successfully used for the preparation of numerous α‐chiral, optically pure amines,...

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Veröffentlicht in:	Advanced synthesis & catalysis 2018-02, Vol.360 (4), p.768-778
Hauptverfasser:	Fuchs, Christine S., Farnberger, Judith E., Steinkellner, Georg, Sattler, Johann H., Pickl, Mathias, Simon, Robert C., Zepeck, Ferdinand, Gruber, Karl, Kroutil, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	amines asymmetric catalysis biotransformations transaminases β-chiral amines
Online-Zugang:	Volltext
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