Remotely Triggerable Drug Delivery Systems
Triggerable drug delivery systems enable on‐demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. Recently, a number of new materials have been developed that exhibit sensitivity to visible light, near‐infrared (NIR) light, ultrasound, or magneti...
Gespeichert in:
| Veröffentlicht in: | Advanced materials (Weinheim) 2010-11, Vol.22 (44), p.4925-4943 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4943 |
|---|---|
| container_issue | 44 |
| container_start_page | 4925 |
| container_title | Advanced materials (Weinheim) |
| container_volume | 22 |
| creator | Timko, Brian P. Dvir, Tal Kohane, Daniel S. |
| description | Triggerable drug delivery systems enable on‐demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. Recently, a number of new materials have been developed that exhibit sensitivity to visible light, near‐infrared (NIR) light, ultrasound, or magnetic fields. This responsiveness can be triggered remotely to provide flexible control of dose magnitude and timing. Here we review triggerable materials that range in scale from nano to macro, and are activated by a range of stimuli.
The ability to provide reproducible, repeated, and safe drug delivery, where the magnitude and period of dosing can be adjusted, could present substantial advantages in the clinic. This review describes devices that could achieve on‐demand drug release in response to remote stimuli. |
| doi_str_mv | 10.1002/adma.201002072 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_adma_201002072</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ADMA201002072</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3822-9168127c63f53b8ff942d18d7e4c20740a508cd0da2b124fe42b39aeda77c1a43</originalsourceid><addsrcrecordid>eNqFkDFPwzAQRi0EoqWwMqLMSCnns-PYY9VAAZWCoIDEYjmxUwUSUTktkH9PqkDFxnQ3fO_TvSPkmMKQAuCZsZUZImx2iHGH9GmENOSgol3SB8WiUAkue-Sgrl8BQAkQ-6SHIKkUVPbJ6b2r3leubIK5LxYL501auiDx60WQuLL4cL4JHpp65ar6kOzlpqzd0c8ckMeL8_n4MpzeTq7Go2mYMYkYKiokxTgTLI9YKvNccbRU2tjxrL2Rg4lAZhaswZQizx3HlCnjrInjjBrOBmTY9Wb-va69y_XSF5XxjaagN6J6I6230i1w0gHLdVo5u43_WrYB1QU-i9I1_9TpUXIz-lsedmzRPuFryxr_pkXM4kg_zyb67voJEZOZfmHfZHZxRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Remotely Triggerable Drug Delivery Systems</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Timko, Brian P. ; Dvir, Tal ; Kohane, Daniel S.</creator><creatorcontrib>Timko, Brian P. ; Dvir, Tal ; Kohane, Daniel S.</creatorcontrib><description>Triggerable drug delivery systems enable on‐demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. Recently, a number of new materials have been developed that exhibit sensitivity to visible light, near‐infrared (NIR) light, ultrasound, or magnetic fields. This responsiveness can be triggered remotely to provide flexible control of dose magnitude and timing. Here we review triggerable materials that range in scale from nano to macro, and are activated by a range of stimuli.
The ability to provide reproducible, repeated, and safe drug delivery, where the magnitude and period of dosing can be adjusted, could present substantial advantages in the clinic. This review describes devices that could achieve on‐demand drug release in response to remote stimuli.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201002072</identifier><identifier>PMID: 20818618</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; drug delivery ; Drug Delivery Systems - instrumentation ; Drug Delivery Systems - methods ; Electrochemistry - methods ; Equipment Design ; Humans ; Light ; Magnetics - methods ; medical applications ; nanoparticles ; Nanostructures - chemistry ; Nanostructures - ultrastructure ; polymeric materials ; Polymers - chemistry ; stimuli-responsive materials ; Ultrasonics - methods</subject><ispartof>Advanced materials (Weinheim), 2010-11, Vol.22 (44), p.4925-4943</ispartof><rights>Copyright © 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3822-9168127c63f53b8ff942d18d7e4c20740a508cd0da2b124fe42b39aeda77c1a43</citedby><cites>FETCH-LOGICAL-c3822-9168127c63f53b8ff942d18d7e4c20740a508cd0da2b124fe42b39aeda77c1a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201002072$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201002072$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20818618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Timko, Brian P.</creatorcontrib><creatorcontrib>Dvir, Tal</creatorcontrib><creatorcontrib>Kohane, Daniel S.</creatorcontrib><title>Remotely Triggerable Drug Delivery Systems</title><title>Advanced materials (Weinheim)</title><addtitle>Adv. Mater</addtitle><description>Triggerable drug delivery systems enable on‐demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. Recently, a number of new materials have been developed that exhibit sensitivity to visible light, near‐infrared (NIR) light, ultrasound, or magnetic fields. This responsiveness can be triggered remotely to provide flexible control of dose magnitude and timing. Here we review triggerable materials that range in scale from nano to macro, and are activated by a range of stimuli.
The ability to provide reproducible, repeated, and safe drug delivery, where the magnitude and period of dosing can be adjusted, could present substantial advantages in the clinic. This review describes devices that could achieve on‐demand drug release in response to remote stimuli.</description><subject>Animals</subject><subject>drug delivery</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Delivery Systems - methods</subject><subject>Electrochemistry - methods</subject><subject>Equipment Design</subject><subject>Humans</subject><subject>Light</subject><subject>Magnetics - methods</subject><subject>medical applications</subject><subject>nanoparticles</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - ultrastructure</subject><subject>polymeric materials</subject><subject>Polymers - chemistry</subject><subject>stimuli-responsive materials</subject><subject>Ultrasonics - methods</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPwzAQRi0EoqWwMqLMSCnns-PYY9VAAZWCoIDEYjmxUwUSUTktkH9PqkDFxnQ3fO_TvSPkmMKQAuCZsZUZImx2iHGH9GmENOSgol3SB8WiUAkue-Sgrl8BQAkQ-6SHIKkUVPbJ6b2r3leubIK5LxYL501auiDx60WQuLL4cL4JHpp65ar6kOzlpqzd0c8ckMeL8_n4MpzeTq7Go2mYMYkYKiokxTgTLI9YKvNccbRU2tjxrL2Rg4lAZhaswZQizx3HlCnjrInjjBrOBmTY9Wb-va69y_XSF5XxjaagN6J6I6230i1w0gHLdVo5u43_WrYB1QU-i9I1_9TpUXIz-lsedmzRPuFryxr_pkXM4kg_zyb67voJEZOZfmHfZHZxRw</recordid><startdate>20101124</startdate><enddate>20101124</enddate><creator>Timko, Brian P.</creator><creator>Dvir, Tal</creator><creator>Kohane, Daniel S.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20101124</creationdate><title>Remotely Triggerable Drug Delivery Systems</title><author>Timko, Brian P. ; Dvir, Tal ; Kohane, Daniel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3822-9168127c63f53b8ff942d18d7e4c20740a508cd0da2b124fe42b39aeda77c1a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>drug delivery</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Drug Delivery Systems - methods</topic><topic>Electrochemistry - methods</topic><topic>Equipment Design</topic><topic>Humans</topic><topic>Light</topic><topic>Magnetics - methods</topic><topic>medical applications</topic><topic>nanoparticles</topic><topic>Nanostructures - chemistry</topic><topic>Nanostructures - ultrastructure</topic><topic>polymeric materials</topic><topic>Polymers - chemistry</topic><topic>stimuli-responsive materials</topic><topic>Ultrasonics - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Timko, Brian P.</creatorcontrib><creatorcontrib>Dvir, Tal</creatorcontrib><creatorcontrib>Kohane, Daniel S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Timko, Brian P.</au><au>Dvir, Tal</au><au>Kohane, Daniel S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Remotely Triggerable Drug Delivery Systems</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv. Mater</addtitle><date>2010-11-24</date><risdate>2010</risdate><volume>22</volume><issue>44</issue><spage>4925</spage><epage>4943</epage><pages>4925-4943</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><abstract>Triggerable drug delivery systems enable on‐demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. Recently, a number of new materials have been developed that exhibit sensitivity to visible light, near‐infrared (NIR) light, ultrasound, or magnetic fields. This responsiveness can be triggered remotely to provide flexible control of dose magnitude and timing. Here we review triggerable materials that range in scale from nano to macro, and are activated by a range of stimuli.
The ability to provide reproducible, repeated, and safe drug delivery, where the magnitude and period of dosing can be adjusted, could present substantial advantages in the clinic. This review describes devices that could achieve on‐demand drug release in response to remote stimuli.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>20818618</pmid><doi>10.1002/adma.201002072</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0935-9648 |
| ispartof | Advanced materials (Weinheim), 2010-11, Vol.22 (44), p.4925-4943 |
| issn | 0935-9648 1521-4095 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_adma_201002072 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals drug delivery Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Electrochemistry - methods Equipment Design Humans Light Magnetics - methods medical applications nanoparticles Nanostructures - chemistry Nanostructures - ultrastructure polymeric materials Polymers - chemistry stimuli-responsive materials Ultrasonics - methods |
| title | Remotely Triggerable Drug Delivery Systems |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T09%3A38%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Remotely%20Triggerable%20Drug%20Delivery%20Systems&rft.jtitle=Advanced%20materials%20(Weinheim)&rft.au=Timko,%20Brian%20P.&rft.date=2010-11-24&rft.volume=22&rft.issue=44&rft.spage=4925&rft.epage=4943&rft.pages=4925-4943&rft.issn=0935-9648&rft.eissn=1521-4095&rft_id=info:doi/10.1002/adma.201002072&rft_dat=%3Cwiley_cross%3EADMA201002072%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/20818618&rfr_iscdi=true |