Modeling Metastatic Colonization in a Decellularized Organ Scaffold‐Based Perfusion Bioreactor (Adv. Healthcare Mater. 1/2022)

Cancer Matastasis Highlighting article number 2100684 by Janine T. Erler, Alejandro E. Mayorca‐Guiliani and co‐workers, this cover represents cancer cells extravasating out of a vessel into a decellularized extracellular matrix (ECM) organ scaffold. Upon arriving in the capillary bed, the cells adhe...

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Veröffentlicht in:Advanced healthcare materials 2022-01, Vol.11 (1), p.n/a
Hauptverfasser: Rafaeva, Maria, Horton, Edward R., Jensen, Adina R.D., Madsen, Chris D., Reuten, Raphael, Willacy, Oliver, Brøchner, Christian B., Jensen, Thomas H., Zornhagen, Kamilla Westarp, Crespo, Marina, Grønseth, Dina S., Nielsen, Sebastian R., Idorn, Manja, Straten, Per thor, Rohrberg, Kristoffer, Spanggaard, Iben, Højgaard, Martin, Lassen, Ulrik, Erler, Janine T., Mayorca‐Guiliani, Alejandro E.
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container_end_page n/a
container_issue 1
container_start_page
container_title Advanced healthcare materials
container_volume 11
creator Rafaeva, Maria
Horton, Edward R.
Jensen, Adina R.D.
Madsen, Chris D.
Reuten, Raphael
Willacy, Oliver
Brøchner, Christian B.
Jensen, Thomas H.
Zornhagen, Kamilla Westarp
Crespo, Marina
Grønseth, Dina S.
Nielsen, Sebastian R.
Idorn, Manja
Straten, Per thor
Rohrberg, Kristoffer
Spanggaard, Iben
Højgaard, Martin
Lassen, Ulrik
Erler, Janine T.
Mayorca‐Guiliani, Alejandro E.
description Cancer Matastasis Highlighting article number 2100684 by Janine T. Erler, Alejandro E. Mayorca‐Guiliani and co‐workers, this cover represents cancer cells extravasating out of a vessel into a decellularized extracellular matrix (ECM) organ scaffold. Upon arriving in the capillary bed, the cells adhere to the ECM and use it to migrate into the organ. The authors' metastasis model system is based on a bioreactor where ECM organ scaffolds are provided with the conditions necessary to sustain cell life. Cell‐ECM interactions coerce cells into behaving as they would in a living organism.
doi_str_mv 10.1002/adhm.202270001
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title Modeling Metastatic Colonization in a Decellularized Organ Scaffold‐Based Perfusion Bioreactor (Adv. Healthcare Mater. 1/2022)
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