Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection (Adv. Funct. Mater. 43/2022)
Flexible Optoelectronics In article number 2205038, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen, and co‐workers present an injectable, reactive oxygen species‐responsive therapeutic hydrogel (ADU‐AAV‐PD1@Gel), capable of sustained local release of soluble PD‐1 (sPD‐1) and STING agonist ADU‐S100. The ADU‐...
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| Veröffentlicht in: | Advanced functional materials 2022-10, Vol.32 (43), p.n/a |
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| creator | Sun, Shuo Gu, Wei Wu, Haisi Zhao, Qianqian Qian, Shiyu Xiao, Hong Yang, Kun Liu, Jian Jin, Yu Hu, Chupeng Gao, Ye Xu, Huae Liu, Hongyi Ji, Jing Chen, Yun |
| description | Flexible Optoelectronics
In article number 2205038, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen, and co‐workers present an injectable, reactive oxygen species‐responsive therapeutic hydrogel (ADU‐AAV‐PD1@Gel), capable of sustained local release of soluble PD‐1 (sPD‐1) and STING agonist ADU‐S100. The ADU‐AAV‐PD1@Gel combined with radiotherapy generates a robust antitumor immune response and induces long‐term immune memory to prevent glioblastoma recurrence. |
| doi_str_mv | 10.1002/adfm.202270246 |
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In article number 2205038, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen, and co‐workers present an injectable, reactive oxygen species‐responsive therapeutic hydrogel (ADU‐AAV‐PD1@Gel), capable of sustained local release of soluble PD‐1 (sPD‐1) and STING agonist ADU‐S100. The ADU‐AAV‐PD1@Gel combined with radiotherapy generates a robust antitumor immune response and induces long‐term immune memory to prevent glioblastoma recurrence.</description><identifier>ISSN: 1616-301X</identifier><identifier>EISSN: 1616-3028</identifier><identifier>DOI: 10.1002/adfm.202270246</identifier><language>eng</language><subject>glioblastoma ; hydrogels ; PD‐1 ; radioimmunotherapy ; STING pathway</subject><ispartof>Advanced functional materials, 2022-10, Vol.32 (43), p.n/a</ispartof><rights>2022 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadfm.202270246$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadfm.202270246$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Sun, Shuo</creatorcontrib><creatorcontrib>Gu, Wei</creatorcontrib><creatorcontrib>Wu, Haisi</creatorcontrib><creatorcontrib>Zhao, Qianqian</creatorcontrib><creatorcontrib>Qian, Shiyu</creatorcontrib><creatorcontrib>Xiao, Hong</creatorcontrib><creatorcontrib>Yang, Kun</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Jin, Yu</creatorcontrib><creatorcontrib>Hu, Chupeng</creatorcontrib><creatorcontrib>Gao, Ye</creatorcontrib><creatorcontrib>Xu, Huae</creatorcontrib><creatorcontrib>Liu, Hongyi</creatorcontrib><creatorcontrib>Ji, Jing</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><title>Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection (Adv. Funct. Mater. 43/2022)</title><title>Advanced functional materials</title><description>Flexible Optoelectronics
In article number 2205038, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen, and co‐workers present an injectable, reactive oxygen species‐responsive therapeutic hydrogel (ADU‐AAV‐PD1@Gel), capable of sustained local release of soluble PD‐1 (sPD‐1) and STING agonist ADU‐S100. The ADU‐AAV‐PD1@Gel combined with radiotherapy generates a robust antitumor immune response and induces long‐term immune memory to prevent glioblastoma recurrence.</description><subject>glioblastoma</subject><subject>hydrogels</subject><subject>PD‐1</subject><subject>radioimmunotherapy</subject><subject>STING pathway</subject><issn>1616-301X</issn><issn>1616-3028</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkLFOwzAQhiMEEqWwMnuEoakdp04yVkDbSK1AbQe2yHYuxSiJI9stysYjsPF-PAkNRWVkun-47z_d53nXBPsE42DI86LyAxwEEQ5CduL1CCNsQHEQnx4zeT73Lqx9xZhEEQ173mdaVdtaW6eqbclrh9IarZTbolmbG72BEqVVY_QOLFq1NZgNOCXRkudKqx_SvYDhTYt0gRa8VJu6K5mWSouSW6crjpZQ8sYCetpf-Xr_WIIF6ZSu0c043_losq2l8_ewA-OjkA67F24vvbOClxaufmffW08e1nezwfxxmt6N5wMZJ2wgk4IUMRdYxCCoCPGIRAlJeJ7ELKKc8VgKJgUhQCVlIhYAPApBiDBgNBwJ2vf8Q6002loDRdYYVXHTZgRnndWss5odre6B5AC8qRLaf7az8f1k8cd-A6f_f2w</recordid><startdate>20221021</startdate><enddate>20221021</enddate><creator>Sun, Shuo</creator><creator>Gu, Wei</creator><creator>Wu, Haisi</creator><creator>Zhao, Qianqian</creator><creator>Qian, Shiyu</creator><creator>Xiao, Hong</creator><creator>Yang, Kun</creator><creator>Liu, Jian</creator><creator>Jin, Yu</creator><creator>Hu, Chupeng</creator><creator>Gao, Ye</creator><creator>Xu, Huae</creator><creator>Liu, Hongyi</creator><creator>Ji, Jing</creator><creator>Chen, Yun</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20221021</creationdate><title>Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection (Adv. Funct. Mater. 43/2022)</title><author>Sun, Shuo ; Gu, Wei ; Wu, Haisi ; Zhao, Qianqian ; Qian, Shiyu ; Xiao, Hong ; Yang, Kun ; Liu, Jian ; Jin, Yu ; Hu, Chupeng ; Gao, Ye ; Xu, Huae ; Liu, Hongyi ; Ji, Jing ; Chen, Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c896-c9f1f8ab0b8eb3b40517919ad98673a6a8cb6cb11e3c36b8beea74ebb426345b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>glioblastoma</topic><topic>hydrogels</topic><topic>PD‐1</topic><topic>radioimmunotherapy</topic><topic>STING pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Shuo</creatorcontrib><creatorcontrib>Gu, Wei</creatorcontrib><creatorcontrib>Wu, Haisi</creatorcontrib><creatorcontrib>Zhao, Qianqian</creatorcontrib><creatorcontrib>Qian, Shiyu</creatorcontrib><creatorcontrib>Xiao, Hong</creatorcontrib><creatorcontrib>Yang, Kun</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Jin, Yu</creatorcontrib><creatorcontrib>Hu, Chupeng</creatorcontrib><creatorcontrib>Gao, Ye</creatorcontrib><creatorcontrib>Xu, Huae</creatorcontrib><creatorcontrib>Liu, Hongyi</creatorcontrib><creatorcontrib>Ji, Jing</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><collection>CrossRef</collection><jtitle>Advanced functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Shuo</au><au>Gu, Wei</au><au>Wu, Haisi</au><au>Zhao, Qianqian</au><au>Qian, Shiyu</au><au>Xiao, Hong</au><au>Yang, Kun</au><au>Liu, Jian</au><au>Jin, Yu</au><au>Hu, Chupeng</au><au>Gao, Ye</au><au>Xu, Huae</au><au>Liu, Hongyi</au><au>Ji, Jing</au><au>Chen, Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection (Adv. Funct. Mater. 43/2022)</atitle><jtitle>Advanced functional materials</jtitle><date>2022-10-21</date><risdate>2022</risdate><volume>32</volume><issue>43</issue><epage>n/a</epage><issn>1616-301X</issn><eissn>1616-3028</eissn><abstract>Flexible Optoelectronics
In article number 2205038, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen, and co‐workers present an injectable, reactive oxygen species‐responsive therapeutic hydrogel (ADU‐AAV‐PD1@Gel), capable of sustained local release of soluble PD‐1 (sPD‐1) and STING agonist ADU‐S100. The ADU‐AAV‐PD1@Gel combined with radiotherapy generates a robust antitumor immune response and induces long‐term immune memory to prevent glioblastoma recurrence.</abstract><doi>10.1002/adfm.202270246</doi><tpages>1</tpages></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | glioblastoma hydrogels PD‐1 radioimmunotherapy STING pathway |
| title | Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection (Adv. Funct. Mater. 43/2022) |
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