Curcumin inhibits CT26 cells metastasis by decreasing heparanase expression

This study tested the hypothesis that heparanase (HPSE) is related to tumor metastasis and curcumin (CCM) inhibits tumor metastasis by down‐regulating HPSE expression. MTT, Transwell assays, and RT‐PCR were used to study the effects of CCM on the migration and invasion of CT26 cells and the expressi...

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Veröffentlicht in:	Journal of leukocyte biology 2020-12, Vol.108 (6), p.1727-1733
Hauptverfasser:	Li, Shanshan, Fu, Hui, Wang, Yiyang, Wang, Li, Jia, Beitian, Bian, Yuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - pathology Curcumin - pharmacology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - immunology Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - immunology Glucuronidase - immunology Humans invasion JAK/STAT5 signal pathway MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology migration Neoplasm Metastasis Neoplasm Proteins - immunology P38 MAPK signal pathway traditional Chinese medicine
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