Exploring the efficiency of thrombin inhibitors with a quantitative model of the coagulation cascade

A detailed mathematical description of the coagulation cascade is a challenging task due to a huge set of protein–protein interactions. Simplified models do not permit quantitative description of anticoagulants. The detailed mathematical model presented here was constructed with 98 reactions between...

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Veröffentlicht in:	FEBS letters 2020-03, Vol.594 (6), p.995-1004
Hauptverfasser:	Zavyalova, Elena G., Ustinov, Nikita B., Kopylov, Alexey M.
Format:	Artikel
Sprache:	eng
Schlagworte:	anticoagulant Aptamers, Nucleotide - pharmacology Blood Coagulation - drug effects coagulation cascade enzyme Factor Xa - metabolism Fibrinolytic Agents - pharmacology Humans kinetics mathematical modeling Models, Cardiovascular Thrombin - metabolism
Online-Zugang:	Volltext
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