Studies on cyanobacterial protein PipY shed light on structure, potential functions, and vitamin B 6 -dependent epilepsy

The Synechococcus elongatus COG0325 gene pipY functionally interacts with the nitrogen regulatory gene pipX. As a first step toward a molecular understanding of such interactions, we characterized PipY. This 221-residue protein is monomeric and hosts pyridoxal phosphate (PLP), binding it with limite...

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Veröffentlicht in:	FEBS letters 2017-10, Vol.591 (20), p.3431-3442
Hauptverfasser:	Tremiño, Lorena, Forcada-Nadal, Alicia, Contreras, Asunción, Rubio, Vicente
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Cloning, Molecular Crystallography, X-Ray Cycloserine - chemistry Cycloserine - metabolism Epilepsy - metabolism Epilepsy - pathology Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Humans Kinetics Models, Molecular Mutagenesis, Site-Directed PII Nitrogen Regulatory Proteins - chemistry PII Nitrogen Regulatory Proteins - genetics PII Nitrogen Regulatory Proteins - metabolism Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Folding Protein Interaction Domains and Motifs Proteins - chemistry Proteins - genetics Proteins - metabolism Pyridoxal Phosphate - chemistry Pyridoxal Phosphate - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Substrate Specificity Synechococcus - chemistry Synechococcus - metabolism Thermodynamics
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