The self‐association of HMGB 1 and its possible role in the binding to DNA and cell membrane receptors
High mobility group box 1 ( HMGB 1), a chromatin protein, interacts with DNA and controls gene expression. However, when HMGB 1 is released from apoptotic or damaged cells, it triggers proinflammatory reactions by interacting with various receptors, mainly receptor for advanced glycation end‐product...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 2017-01, Vol.591 (2), p.282-294 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 294 |
|---|---|
| container_issue | 2 |
| container_start_page | 282 |
| container_title | FEBS letters |
| container_volume | 591 |
| creator | Anggayasti, Wresti L. Mancera, Ricardo L. Bottomley, Steve Helmerhorst, Erik |
| description | High mobility group box 1 (
HMGB
1), a chromatin protein, interacts with
DNA
and controls gene expression. However, when
HMGB
1 is released from apoptotic or damaged cells, it triggers proinflammatory reactions by interacting with various receptors, mainly receptor for advanced glycation end‐products (
RAGE
) and toll‐like receptors (
TLR
s). The self‐association of
HMGB
1 has been found to be crucial for its
DNA
‐related biological functions. It is influenced by several factors, such as ionic strength,
pH
, specific divalent metal cations, redox environment and acetylation. This self‐association may also play a role in the interaction with
RAGE
and
TLR
s and the concomitant inflammatory responses. Future studies should address the potential role of
HMGB
1 self‐association on its interactions with
DNA
,
RAGE
and
TLR
s, as well as the influence of physicochemical factors in different cellular environments on these interactions. |
| doi_str_mv | 10.1002/1873-3468.12545 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1002_1873_3468_12545</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1002_1873_3468_12545</sourcerecordid><originalsourceid>FETCH-LOGICAL-c865-9a57cc883e0405760cb523017ae71220f3c8f3bd01de922d6afe4e470b8546083</originalsourceid><addsrcrecordid>eNo9kE1OwzAQhS0EEqWwZusLpB3_xc6yFGiRCmy6jxxnTI3SuLKzYccROCMnIS2IzRu9pzej0UfILYMZA-BzZrQohCzNjHEl1RmZ_CfnZALAZKF0JS7JVc7vMHrDqgnZbXdIM3b--_PL5hxdsEOIPY2erp9Xd5RR27c0DJkeYs6h6ZCmOEro6TBuNqFvQ_9Gh0jvXxanrsOuo3vcN8n2YxkdHoaY8jW58LbLePM3p2T7-LBdrovN6-ppudgUzpSqqKzSzhkjECQoXYJrFBfAtEXNOAcvnPGiaYG1WHHeltajRKmhMUqWYMSUzH_PujT-m9DXhxT2Nn3UDOojp_pIpT5SqU-cxA-C2Vpz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The self‐association of HMGB 1 and its possible role in the binding to DNA and cell membrane receptors</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Anggayasti, Wresti L. ; Mancera, Ricardo L. ; Bottomley, Steve ; Helmerhorst, Erik</creator><creatorcontrib>Anggayasti, Wresti L. ; Mancera, Ricardo L. ; Bottomley, Steve ; Helmerhorst, Erik</creatorcontrib><description>High mobility group box 1 (
HMGB
1), a chromatin protein, interacts with
DNA
and controls gene expression. However, when
HMGB
1 is released from apoptotic or damaged cells, it triggers proinflammatory reactions by interacting with various receptors, mainly receptor for advanced glycation end‐products (
RAGE
) and toll‐like receptors (
TLR
s). The self‐association of
HMGB
1 has been found to be crucial for its
DNA
‐related biological functions. It is influenced by several factors, such as ionic strength,
pH
, specific divalent metal cations, redox environment and acetylation. This self‐association may also play a role in the interaction with
RAGE
and
TLR
s and the concomitant inflammatory responses. Future studies should address the potential role of
HMGB
1 self‐association on its interactions with
DNA
,
RAGE
and
TLR
s, as well as the influence of physicochemical factors in different cellular environments on these interactions.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1002/1873-3468.12545</identifier><language>eng</language><ispartof>FEBS letters, 2017-01, Vol.591 (2), p.282-294</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c865-9a57cc883e0405760cb523017ae71220f3c8f3bd01de922d6afe4e470b8546083</citedby><cites>FETCH-LOGICAL-c865-9a57cc883e0405760cb523017ae71220f3c8f3bd01de922d6afe4e470b8546083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Anggayasti, Wresti L.</creatorcontrib><creatorcontrib>Mancera, Ricardo L.</creatorcontrib><creatorcontrib>Bottomley, Steve</creatorcontrib><creatorcontrib>Helmerhorst, Erik</creatorcontrib><title>The self‐association of HMGB 1 and its possible role in the binding to DNA and cell membrane receptors</title><title>FEBS letters</title><description>High mobility group box 1 (
HMGB
1), a chromatin protein, interacts with
DNA
and controls gene expression. However, when
HMGB
1 is released from apoptotic or damaged cells, it triggers proinflammatory reactions by interacting with various receptors, mainly receptor for advanced glycation end‐products (
RAGE
) and toll‐like receptors (
TLR
s). The self‐association of
HMGB
1 has been found to be crucial for its
DNA
‐related biological functions. It is influenced by several factors, such as ionic strength,
pH
, specific divalent metal cations, redox environment and acetylation. This self‐association may also play a role in the interaction with
RAGE
and
TLR
s and the concomitant inflammatory responses. Future studies should address the potential role of
HMGB
1 self‐association on its interactions with
DNA
,
RAGE
and
TLR
s, as well as the influence of physicochemical factors in different cellular environments on these interactions.</description><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNo9kE1OwzAQhS0EEqWwZusLpB3_xc6yFGiRCmy6jxxnTI3SuLKzYccROCMnIS2IzRu9pzej0UfILYMZA-BzZrQohCzNjHEl1RmZ_CfnZALAZKF0JS7JVc7vMHrDqgnZbXdIM3b--_PL5hxdsEOIPY2erp9Xd5RR27c0DJkeYs6h6ZCmOEro6TBuNqFvQ_9Gh0jvXxanrsOuo3vcN8n2YxkdHoaY8jW58LbLePM3p2T7-LBdrovN6-ppudgUzpSqqKzSzhkjECQoXYJrFBfAtEXNOAcvnPGiaYG1WHHeltajRKmhMUqWYMSUzH_PujT-m9DXhxT2Nn3UDOojp_pIpT5SqU-cxA-C2Vpz</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Anggayasti, Wresti L.</creator><creator>Mancera, Ricardo L.</creator><creator>Bottomley, Steve</creator><creator>Helmerhorst, Erik</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201701</creationdate><title>The self‐association of HMGB 1 and its possible role in the binding to DNA and cell membrane receptors</title><author>Anggayasti, Wresti L. ; Mancera, Ricardo L. ; Bottomley, Steve ; Helmerhorst, Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c865-9a57cc883e0405760cb523017ae71220f3c8f3bd01de922d6afe4e470b8546083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anggayasti, Wresti L.</creatorcontrib><creatorcontrib>Mancera, Ricardo L.</creatorcontrib><creatorcontrib>Bottomley, Steve</creatorcontrib><creatorcontrib>Helmerhorst, Erik</creatorcontrib><collection>CrossRef</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anggayasti, Wresti L.</au><au>Mancera, Ricardo L.</au><au>Bottomley, Steve</au><au>Helmerhorst, Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The self‐association of HMGB 1 and its possible role in the binding to DNA and cell membrane receptors</atitle><jtitle>FEBS letters</jtitle><date>2017-01</date><risdate>2017</risdate><volume>591</volume><issue>2</issue><spage>282</spage><epage>294</epage><pages>282-294</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>High mobility group box 1 (
HMGB
1), a chromatin protein, interacts with
DNA
and controls gene expression. However, when
HMGB
1 is released from apoptotic or damaged cells, it triggers proinflammatory reactions by interacting with various receptors, mainly receptor for advanced glycation end‐products (
RAGE
) and toll‐like receptors (
TLR
s). The self‐association of
HMGB
1 has been found to be crucial for its
DNA
‐related biological functions. It is influenced by several factors, such as ionic strength,
pH
, specific divalent metal cations, redox environment and acetylation. This self‐association may also play a role in the interaction with
RAGE
and
TLR
s and the concomitant inflammatory responses. Future studies should address the potential role of
HMGB
1 self‐association on its interactions with
DNA
,
RAGE
and
TLR
s, as well as the influence of physicochemical factors in different cellular environments on these interactions.</abstract><doi>10.1002/1873-3468.12545</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2017-01, Vol.591 (2), p.282-294 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_1873_3468_12545 |
| source | Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | The self‐association of HMGB 1 and its possible role in the binding to DNA and cell membrane receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T21%3A33%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20self%E2%80%90association%20of%20HMGB%201%20and%20its%20possible%20role%20in%20the%20binding%20to%20DNA%20and%20cell%20membrane%20receptors&rft.jtitle=FEBS%20letters&rft.au=Anggayasti,%20Wresti%20L.&rft.date=2017-01&rft.volume=591&rft.issue=2&rft.spage=282&rft.epage=294&rft.pages=282-294&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1002/1873-3468.12545&rft_dat=%3Ccrossref%3E10_1002_1873_3468_12545%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |