PAUPAR lnc RNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma
Uveal melanoma ( UM ) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with UM develop metastases after diagnosis. Long noncoding RNAs (lncRNAs) are involved in both oncogenic and tumour suppression pathways. We show that lnc RNA PAUPAR is pres...
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| Veröffentlicht in: | FEBS letters 2016-06, Vol.590 (12), p.1729-1738 |
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| creator | Ding, Xia Wang, Xi Lin, Ming Xing, Yue Ge, Shengfang Jia, Renbing Zhang, He Fan, Xianqun Li, Jin |
| description | Uveal melanoma (
UM
) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with
UM
develop metastases after diagnosis. Long noncoding
RNAs
(lncRNAs) are involved in both oncogenic and tumour suppression pathways. We show that lnc
RNA
PAUPAR
is present at low levels in
UM
tissues and cell lines and modulates the tumourigenesis of
UM
in vitro
and
in vivo
. The ectopic expression of
PAUPAR
in
UM
cells revealed that
PAUPAR
acts as a necessary
UM
suppressor and induces the silencing of
HES
1 expression, which significantly reduces tumour metastasis. Mechanistically,
PAUPAR
modulates
HES
1
expression by inhibiting histone H3K4 methylation. These data support a role of this lnc
RNA
as a novel therapeutic target in cancer prevention and treatment. |
| doi_str_mv | 10.1002/1873-3468.12220 |
| format | Article |
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UM
) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with
UM
develop metastases after diagnosis. Long noncoding
RNAs
(lncRNAs) are involved in both oncogenic and tumour suppression pathways. We show that lnc
RNA
PAUPAR
is present at low levels in
UM
tissues and cell lines and modulates the tumourigenesis of
UM
in vitro
and
in vivo
. The ectopic expression of
PAUPAR
in
UM
cells revealed that
PAUPAR
acts as a necessary
UM
suppressor and induces the silencing of
HES
1 expression, which significantly reduces tumour metastasis. Mechanistically,
PAUPAR
modulates
HES
1
expression by inhibiting histone H3K4 methylation. These data support a role of this lnc
RNA
as a novel therapeutic target in cancer prevention and treatment.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1002/1873-3468.12220</identifier><language>eng</language><ispartof>FEBS letters, 2016-06, Vol.590 (12), p.1729-1738</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c860-9f551a75a0b7dd2759a04849e1c1d57f425eebe22656dfee0997d5aec8f263dd3</citedby><cites>FETCH-LOGICAL-c860-9f551a75a0b7dd2759a04849e1c1d57f425eebe22656dfee0997d5aec8f263dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ding, Xia</creatorcontrib><creatorcontrib>Wang, Xi</creatorcontrib><creatorcontrib>Lin, Ming</creatorcontrib><creatorcontrib>Xing, Yue</creatorcontrib><creatorcontrib>Ge, Shengfang</creatorcontrib><creatorcontrib>Jia, Renbing</creatorcontrib><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Fan, Xianqun</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><title>PAUPAR lnc RNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma</title><title>FEBS letters</title><description>Uveal melanoma (
UM
) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with
UM
develop metastases after diagnosis. Long noncoding
RNAs
(lncRNAs) are involved in both oncogenic and tumour suppression pathways. We show that lnc
RNA
PAUPAR
is present at low levels in
UM
tissues and cell lines and modulates the tumourigenesis of
UM
in vitro
and
in vivo
. The ectopic expression of
PAUPAR
in
UM
cells revealed that
PAUPAR
acts as a necessary
UM
suppressor and induces the silencing of
HES
1 expression, which significantly reduces tumour metastasis. Mechanistically,
PAUPAR
modulates
HES
1
expression by inhibiting histone H3K4 methylation. These data support a role of this lnc
RNA
as a novel therapeutic target in cancer prevention and treatment.</description><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNo9kEtLxDAYRYMoWEfXbvMHOpNH0yTLMqgjDlqGcR3S5otW-hiSVui_16q4uty7uHAOQreUrCkhbEOV5CnPcrWmjDFyhpL_5RwlhNAsFVLzS3QV4wf57orqBJVl8VoWB9z2NT48FzhOp1OAGCHiceqGKTRv0ENsIq5mvONPGXbQwfg-t3Zshh43PZ4-wba4g9b2Q2ev0YW3bYSbv1yh4_3dcbtL9y8Pj9tin9YqJ6n2QlArhSWVdI5JoS3JVKaB1tQJ6TMmACpgLBe58wBEa-mEhVp5lnPn-Aptfm_rMMQYwJtTaDobZkOJWXyYhd4s9ObHB_8CA4ZSmA</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Ding, Xia</creator><creator>Wang, Xi</creator><creator>Lin, Ming</creator><creator>Xing, Yue</creator><creator>Ge, Shengfang</creator><creator>Jia, Renbing</creator><creator>Zhang, He</creator><creator>Fan, Xianqun</creator><creator>Li, Jin</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201606</creationdate><title>PAUPAR lnc RNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma</title><author>Ding, Xia ; Wang, Xi ; Lin, Ming ; Xing, Yue ; Ge, Shengfang ; Jia, Renbing ; Zhang, He ; Fan, Xianqun ; Li, Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c860-9f551a75a0b7dd2759a04849e1c1d57f425eebe22656dfee0997d5aec8f263dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Xia</creatorcontrib><creatorcontrib>Wang, Xi</creatorcontrib><creatorcontrib>Lin, Ming</creatorcontrib><creatorcontrib>Xing, Yue</creatorcontrib><creatorcontrib>Ge, Shengfang</creatorcontrib><creatorcontrib>Jia, Renbing</creatorcontrib><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Fan, Xianqun</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><collection>CrossRef</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Xia</au><au>Wang, Xi</au><au>Lin, Ming</au><au>Xing, Yue</au><au>Ge, Shengfang</au><au>Jia, Renbing</au><au>Zhang, He</au><au>Fan, Xianqun</au><au>Li, Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PAUPAR lnc RNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma</atitle><jtitle>FEBS letters</jtitle><date>2016-06</date><risdate>2016</risdate><volume>590</volume><issue>12</issue><spage>1729</spage><epage>1738</epage><pages>1729-1738</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Uveal melanoma (
UM
) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with
UM
develop metastases after diagnosis. Long noncoding
RNAs
(lncRNAs) are involved in both oncogenic and tumour suppression pathways. We show that lnc
RNA
PAUPAR
is present at low levels in
UM
tissues and cell lines and modulates the tumourigenesis of
UM
in vitro
and
in vivo
. The ectopic expression of
PAUPAR
in
UM
cells revealed that
PAUPAR
acts as a necessary
UM
suppressor and induces the silencing of
HES
1 expression, which significantly reduces tumour metastasis. Mechanistically,
PAUPAR
modulates
HES
1
expression by inhibiting histone H3K4 methylation. These data support a role of this lnc
RNA
as a novel therapeutic target in cancer prevention and treatment.</abstract><doi>10.1002/1873-3468.12220</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2016-06, Vol.590 (12), p.1729-1738 |
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| language | eng |
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| source | Wiley Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| title | PAUPAR lnc RNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma |
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