Assessing Cell Fusion and Cytokinesis Failure as Mechanisms of Clone 9 Hepatocyte Multinucleation In Vitro

In this in vitro model of hepatocyte multinucleation, separate cultures of rat Clone 9 cells are labeled with either red or green cell tracker dyes (Red Cell Tracker CMPTX or Vybrant CFDA SE Cell Tracer), plated together in mixed‐color colonies, and treated with positive or negative control agents f...

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Veröffentlicht in:	Current Protocols in Toxicology 2012-08, Vol.53 (1), p.14.9.1-14.9.17
Hauptverfasser:	Simic, Damir, Euler, Catherine, Thurby, Christina, Peden, Mike, Tannehill‐Gregg, Sarah, Bunch, Todd, Sanderson, Thomas, Vleet, Terry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay - methods Cell Fusion Cells, Cultured Clone 9 Clone Cells - cytology Clone Cells - drug effects cytokinesis Cytokinesis - drug effects Fluorescent Dyes hepatocyte Hepatocytes - cytology Hepatocytes - drug effects Hybrid Cells - drug effects multinucleation Rats Staining and Labeling - methods Toxicity Tests - methods Xenobiotics - toxicity
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