Patterns of transmitted HIV drug resistance in Europe vary by risk group
Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countr...
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| creator | Frentz, Dineke van de Vijver, David A Abecasis, Ana B Albert, Jan Hamouda, Osamah Jørgensen, Louise B Kücherer, Claudia Struck, Daniel Schmit, Jean-Claude Vercauteren, Jürgen Åsjø, Birgitta Balotta, Claudia Bergin, Colm Beshkov, Danail Camacho, Ricardo Clotet, Bonaventura Griskevicius, Algirdas Grossman, Zehava Horban, Andrzej Kolupajeva, Tatjana Korn, Klaus Kostrikis, Leondios Linka, Kirsi Litsola Marek Nielsen, Claus Otelea, Dan Paraskevis, Dimitrios Paredes, Roger Poljak, Mario Puchhammer-Stöckl, Elisabeth Sönnerborg, Anders Stanekova, Danica Stanojevic, Maja Vandamme, Anne-Mieke Boucher, Charles A.B Wensing, Annemarie |
| description | Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected ( |
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| fullrecord | <record><control><sourceid>cristin_3HK</sourceid><recordid>TN_cdi_cristin_nora_1956_9690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1956_9690</sourcerecordid><originalsourceid>FETCH-cristin_nora_1956_96903</originalsourceid><addsrcrecordid>eNrjZPAISCwpSS3KK1bIT1MoKUrMK87NBAqkKHh4himkFJWmKxSlFmcWlyTmJacqZOYpuJYW5RekKpQlFlUqJFUqFGUWZyukF-WXFvAwsKYl5hSn8kJpbgZZN9cQZw_dZKCaksy8-Lz8osR4Q0tTs3hLM0sDY0LyAO31MiQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Patterns of transmitted HIV drug resistance in Europe vary by risk group</title><source>NORA - Norwegian Open Research Archives</source><creator>Frentz, Dineke ; van de Vijver, David A ; Abecasis, Ana B ; Albert, Jan ; Hamouda, Osamah ; Jørgensen, Louise B ; Kücherer, Claudia ; Struck, Daniel ; Schmit, Jean-Claude ; Vercauteren, Jürgen ; Åsjø, Birgitta ; Balotta, Claudia ; Bergin, Colm ; Beshkov, Danail ; Camacho, Ricardo ; Clotet, Bonaventura ; Griskevicius, Algirdas ; Grossman, Zehava ; Horban, Andrzej ; Kolupajeva, Tatjana ; Korn, Klaus ; Kostrikis, Leondios ; Linka, Kirsi Litsola Marek ; Nielsen, Claus ; Otelea, Dan ; Paraskevis, Dimitrios ; Paredes, Roger ; Poljak, Mario ; Puchhammer-Stöckl, Elisabeth ; Sönnerborg, Anders ; Stanekova, Danica ; Stanojevic, Maja ; Vandamme, Anne-Mieke ; Boucher, Charles A.B ; Wensing, Annemarie</creator><creatorcontrib>Frentz, Dineke ; van de Vijver, David A ; Abecasis, Ana B ; Albert, Jan ; Hamouda, Osamah ; Jørgensen, Louise B ; Kücherer, Claudia ; Struck, Daniel ; Schmit, Jean-Claude ; Vercauteren, Jürgen ; Åsjø, Birgitta ; Balotta, Claudia ; Bergin, Colm ; Beshkov, Danail ; Camacho, Ricardo ; Clotet, Bonaventura ; Griskevicius, Algirdas ; Grossman, Zehava ; Horban, Andrzej ; Kolupajeva, Tatjana ; Korn, Klaus ; Kostrikis, Leondios ; Linka, Kirsi Litsola Marek ; Nielsen, Claus ; Otelea, Dan ; Paraskevis, Dimitrios ; Paredes, Roger ; Poljak, Mario ; Puchhammer-Stöckl, Elisabeth ; Sönnerborg, Anders ; Stanekova, Danica ; Stanojevic, Maja ; Vandamme, Anne-Mieke ; Boucher, Charles A.B ; Wensing, Annemarie</creatorcontrib><description>Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (<1 year) (p<0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p,0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p = 0.008 and p = 0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively). Conclusions: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs.</description><language>eng</language><publisher>PLoS</publisher><creationdate>2014</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,26544</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/1956/9690$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Frentz, Dineke</creatorcontrib><creatorcontrib>van de Vijver, David A</creatorcontrib><creatorcontrib>Abecasis, Ana B</creatorcontrib><creatorcontrib>Albert, Jan</creatorcontrib><creatorcontrib>Hamouda, Osamah</creatorcontrib><creatorcontrib>Jørgensen, Louise B</creatorcontrib><creatorcontrib>Kücherer, Claudia</creatorcontrib><creatorcontrib>Struck, Daniel</creatorcontrib><creatorcontrib>Schmit, Jean-Claude</creatorcontrib><creatorcontrib>Vercauteren, Jürgen</creatorcontrib><creatorcontrib>Åsjø, Birgitta</creatorcontrib><creatorcontrib>Balotta, Claudia</creatorcontrib><creatorcontrib>Bergin, Colm</creatorcontrib><creatorcontrib>Beshkov, Danail</creatorcontrib><creatorcontrib>Camacho, Ricardo</creatorcontrib><creatorcontrib>Clotet, Bonaventura</creatorcontrib><creatorcontrib>Griskevicius, Algirdas</creatorcontrib><creatorcontrib>Grossman, Zehava</creatorcontrib><creatorcontrib>Horban, Andrzej</creatorcontrib><creatorcontrib>Kolupajeva, Tatjana</creatorcontrib><creatorcontrib>Korn, Klaus</creatorcontrib><creatorcontrib>Kostrikis, Leondios</creatorcontrib><creatorcontrib>Linka, Kirsi Litsola Marek</creatorcontrib><creatorcontrib>Nielsen, Claus</creatorcontrib><creatorcontrib>Otelea, Dan</creatorcontrib><creatorcontrib>Paraskevis, Dimitrios</creatorcontrib><creatorcontrib>Paredes, Roger</creatorcontrib><creatorcontrib>Poljak, Mario</creatorcontrib><creatorcontrib>Puchhammer-Stöckl, Elisabeth</creatorcontrib><creatorcontrib>Sönnerborg, Anders</creatorcontrib><creatorcontrib>Stanekova, Danica</creatorcontrib><creatorcontrib>Stanojevic, Maja</creatorcontrib><creatorcontrib>Vandamme, Anne-Mieke</creatorcontrib><creatorcontrib>Boucher, Charles A.B</creatorcontrib><creatorcontrib>Wensing, Annemarie</creatorcontrib><title>Patterns of transmitted HIV drug resistance in Europe vary by risk group</title><description>Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (<1 year) (p<0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p,0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p = 0.008 and p = 0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively). Conclusions: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs.</description><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNrjZPAISCwpSS3KK1bIT1MoKUrMK87NBAqkKHh4himkFJWmKxSlFmcWlyTmJacqZOYpuJYW5RekKpQlFlUqJFUqFGUWZyukF-WXFvAwsKYl5hSn8kJpbgZZN9cQZw_dZKCaksy8-Lz8osR4Q0tTs3hLM0sDY0LyAO31MiQ</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Frentz, Dineke</creator><creator>van de Vijver, David A</creator><creator>Abecasis, Ana B</creator><creator>Albert, Jan</creator><creator>Hamouda, Osamah</creator><creator>Jørgensen, Louise B</creator><creator>Kücherer, Claudia</creator><creator>Struck, Daniel</creator><creator>Schmit, Jean-Claude</creator><creator>Vercauteren, Jürgen</creator><creator>Åsjø, Birgitta</creator><creator>Balotta, Claudia</creator><creator>Bergin, Colm</creator><creator>Beshkov, Danail</creator><creator>Camacho, Ricardo</creator><creator>Clotet, Bonaventura</creator><creator>Griskevicius, Algirdas</creator><creator>Grossman, Zehava</creator><creator>Horban, Andrzej</creator><creator>Kolupajeva, Tatjana</creator><creator>Korn, Klaus</creator><creator>Kostrikis, Leondios</creator><creator>Linka, Kirsi Litsola Marek</creator><creator>Nielsen, Claus</creator><creator>Otelea, Dan</creator><creator>Paraskevis, Dimitrios</creator><creator>Paredes, Roger</creator><creator>Poljak, Mario</creator><creator>Puchhammer-Stöckl, Elisabeth</creator><creator>Sönnerborg, Anders</creator><creator>Stanekova, Danica</creator><creator>Stanojevic, Maja</creator><creator>Vandamme, Anne-Mieke</creator><creator>Boucher, Charles A.B</creator><creator>Wensing, Annemarie</creator><general>PLoS</general><scope>3HK</scope></search><sort><creationdate>2014</creationdate><title>Patterns of transmitted HIV drug resistance in Europe vary by risk group</title><author>Frentz, Dineke ; van de Vijver, David A ; Abecasis, Ana B ; Albert, Jan ; Hamouda, Osamah ; Jørgensen, Louise B ; Kücherer, Claudia ; Struck, Daniel ; Schmit, Jean-Claude ; Vercauteren, Jürgen ; Åsjø, Birgitta ; Balotta, Claudia ; Bergin, Colm ; Beshkov, Danail ; Camacho, Ricardo ; Clotet, Bonaventura ; Griskevicius, Algirdas ; Grossman, Zehava ; Horban, Andrzej ; Kolupajeva, Tatjana ; Korn, Klaus ; Kostrikis, Leondios ; Linka, Kirsi Litsola Marek ; Nielsen, Claus ; Otelea, Dan ; Paraskevis, Dimitrios ; Paredes, Roger ; Poljak, Mario ; Puchhammer-Stöckl, Elisabeth ; Sönnerborg, Anders ; Stanekova, Danica ; Stanojevic, Maja ; Vandamme, Anne-Mieke ; Boucher, Charles A.B ; Wensing, Annemarie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-cristin_nora_1956_96903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Frentz, Dineke</creatorcontrib><creatorcontrib>van de Vijver, David A</creatorcontrib><creatorcontrib>Abecasis, Ana B</creatorcontrib><creatorcontrib>Albert, Jan</creatorcontrib><creatorcontrib>Hamouda, Osamah</creatorcontrib><creatorcontrib>Jørgensen, Louise B</creatorcontrib><creatorcontrib>Kücherer, Claudia</creatorcontrib><creatorcontrib>Struck, Daniel</creatorcontrib><creatorcontrib>Schmit, Jean-Claude</creatorcontrib><creatorcontrib>Vercauteren, Jürgen</creatorcontrib><creatorcontrib>Åsjø, Birgitta</creatorcontrib><creatorcontrib>Balotta, Claudia</creatorcontrib><creatorcontrib>Bergin, Colm</creatorcontrib><creatorcontrib>Beshkov, Danail</creatorcontrib><creatorcontrib>Camacho, Ricardo</creatorcontrib><creatorcontrib>Clotet, Bonaventura</creatorcontrib><creatorcontrib>Griskevicius, Algirdas</creatorcontrib><creatorcontrib>Grossman, Zehava</creatorcontrib><creatorcontrib>Horban, Andrzej</creatorcontrib><creatorcontrib>Kolupajeva, Tatjana</creatorcontrib><creatorcontrib>Korn, Klaus</creatorcontrib><creatorcontrib>Kostrikis, Leondios</creatorcontrib><creatorcontrib>Linka, Kirsi Litsola Marek</creatorcontrib><creatorcontrib>Nielsen, Claus</creatorcontrib><creatorcontrib>Otelea, Dan</creatorcontrib><creatorcontrib>Paraskevis, Dimitrios</creatorcontrib><creatorcontrib>Paredes, Roger</creatorcontrib><creatorcontrib>Poljak, Mario</creatorcontrib><creatorcontrib>Puchhammer-Stöckl, Elisabeth</creatorcontrib><creatorcontrib>Sönnerborg, Anders</creatorcontrib><creatorcontrib>Stanekova, Danica</creatorcontrib><creatorcontrib>Stanojevic, Maja</creatorcontrib><creatorcontrib>Vandamme, Anne-Mieke</creatorcontrib><creatorcontrib>Boucher, Charles A.B</creatorcontrib><creatorcontrib>Wensing, Annemarie</creatorcontrib><collection>NORA - Norwegian Open Research Archives</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Frentz, Dineke</au><au>van de Vijver, David A</au><au>Abecasis, Ana B</au><au>Albert, Jan</au><au>Hamouda, Osamah</au><au>Jørgensen, Louise B</au><au>Kücherer, Claudia</au><au>Struck, Daniel</au><au>Schmit, Jean-Claude</au><au>Vercauteren, Jürgen</au><au>Åsjø, Birgitta</au><au>Balotta, Claudia</au><au>Bergin, Colm</au><au>Beshkov, Danail</au><au>Camacho, Ricardo</au><au>Clotet, Bonaventura</au><au>Griskevicius, Algirdas</au><au>Grossman, Zehava</au><au>Horban, Andrzej</au><au>Kolupajeva, Tatjana</au><au>Korn, Klaus</au><au>Kostrikis, Leondios</au><au>Linka, Kirsi Litsola Marek</au><au>Nielsen, Claus</au><au>Otelea, Dan</au><au>Paraskevis, Dimitrios</au><au>Paredes, Roger</au><au>Poljak, Mario</au><au>Puchhammer-Stöckl, Elisabeth</au><au>Sönnerborg, Anders</au><au>Stanekova, Danica</au><au>Stanojevic, Maja</au><au>Vandamme, Anne-Mieke</au><au>Boucher, Charles A.B</au><au>Wensing, Annemarie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of transmitted HIV drug resistance in Europe vary by risk group</atitle><date>2014</date><risdate>2014</risdate><abstract>Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (<1 year) (p<0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p,0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p = 0.008 and p = 0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively). Conclusions: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs.</abstract><pub>PLoS</pub><oa>free_for_read</oa></addata></record> |
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| title | Patterns of transmitted HIV drug resistance in Europe vary by risk group |
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