Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets

Platelet activation contributes to normal haemostasis but also to pathologic conditions like stroke and cardiac infarction. Signalling by cGMP and cAMP inhibit platelet activation and are therefore attractive targets for thrombosis prevention. However, extensive cross-talk between the cGMP and cAMP...

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Hauptverfasser:	Kleppe, Rune, Jonassen, Inge, Doskeland, Stein Ove, Selheim, Frode
Format:	Artikel
Sprache:	eng
Schlagworte:	cAMP signalling cGMP signalling mathematical modelling nitric oxide PDE2 PDE3 PDE5 phosphodiesterase platelets
Online-Zugang:	Volltext bestellen
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