The NEOLETRIB trial: neoadjuvant treatment with Letrozole and Ribociclib in ER-positive, HER2-negative breast cancer
Chemotherapy is used as neoadjuvant therapy for all subgroups of breast cancer, including ER-positive, and HER2-negative cases. However, studies have suggested that using aromatase inhibitors combined with CDK4/6-inhibitors might be an appropriate alternative in selected patients. Thus, the NEOLETRI...
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| creator | Fjermeros, Kamilla Ghannoum, Salim Geisler, Stephanie Bhargava, Sameer Tahiri, Andliena Klajic, Jovana Lüders, Torben Fongård, Marie Nawaz, Meh Sameen Bosnjak-Olsen, Tatjana Buvarp, Unn-Cathrin Edvardsen Rosenskiold, Aino Katri Johanna Nguyen, Nam Thi Sletbak, Tone Tyskø Seyedzadeh, Manouchehr Selsås, Knut Porojnicu, Alina Carmen Skjerven, Helle Hovda, Tone Sahlberg, Guro Kristine Kleivi Torland, Anne Vold Lyngra, Marianne Hammarström, Clara Louise Hönigsperger, Elma Bahonjic Noone, John Christopher Mathiassen, Silje Hurtado, Antoni Goel, Shom Koff, Andrew Tekpli, Xavier Kristensen, Vessela N Geisler, Jürgen |
| description | Chemotherapy is used as neoadjuvant therapy for all subgroups of breast cancer, including ER-positive, and HER2-negative cases. However, studies have suggested that using aromatase inhibitors combined with CDK4/6-inhibitors might be an appropriate alternative in selected patients. Thus, the NEOLETRIB trial evaluates the response of ER-positive, HER2-negative luminal A/B breast cancer to the combination of letrozole and ribociclib in the neoadjuvant setting. Comprehensive molecular biology procedures, including sequential single-cell RNA-sequencing of tumor biopsies, are performed during 6 months of treatment with extensive biobanking of blood samples, tumor biopsies and gut microbiome specimens. Our findings will hopefully contribute to an improved selection of patients who may benefit from this drug combination and give new insights into the intra-tumoral changes during this treatment. |
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| subjects | Breast neoplasms Gastrointestinal microbiome Neoadjuvant therapy |
| title | The NEOLETRIB trial: neoadjuvant treatment with Letrozole and Ribociclib in ER-positive, HER2-negative breast cancer |
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