Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Beaumont, Robin N Flatley, Christopher Vaudel, Marc Wu, Xiaoping Chen, Jing Moen, Gunn-Helen Øiseth Skotte, Line Helgeland, Øyvind Solé-Navais, Pol Banasik, Karina Albiñana, Clara Ronkainen, Justiina Fadista, João Stinson, Sara Elizabeth Trajanoska, Katerina Wang, Carol A Westergaard, David Srinivasan, Sundararajan Sánchez-Soriano, Carlos Bilbao, Jose Ramon Allard, Catherine Groleau, Marika Kuulasmaa, Teemu Leirer, Daniel J White, Frédérique Jacques, Pierre-Étienne Cheng, Haoxiang Hao, Ke Andreassen, Ole Åsvold, Bjørn Olav Atalay, Mustafa Bhatta, Laxmi Bouchard, Luigi Brumpton, Ben Michael Brunak, Søren Bybjerg-Grauholm, Jonas Ebbing, Cathrine Elliott, Paul Engelbrechtsen, Line Erikstrup, Christian Estarlich, Marisa Franks, Stephen Gaillard, Romy Geller, Frank Grove, Jakob Hougaard, David M Kajantie, Eero Olavi Morgen, Camilla S Nøhr, Ellen Aagaard Nyegaard, Mette Palmer, Colin N. A Pedersen, Ole Birger Rivadeneira, Fernando Sebert, Sylvain Shields, Beverley M Stoltenberg, Camilla Surakka, Ida Thørner, Lise Wegner Ullum, Henrik Vaarasmaki, Marja Vilhjalmsson, Bjarni J Willer, Cristen J Lakka, Timo A Gybel-Brask, Dorte Bustamante, Mariona Hansen, Torben Pearson, Ewan R Reynolds, Rebecca M Ostrowski, Sisse R Pennell, Craig E Jaddoe, Vincent W. V Felix, Janine F Hattersley, Andrew T Melbye, Mads Lawlor, Deborah A Hveem, Kristian Werge, Thomas Nielsen, Henriette Svarre Magnus, Per Minor Evans, David M Jacobsson, Bo Järvelin, Marjo-Riitta Zhang, Ge Hivert, Marie-France Johansson, Stefan Freathy, Rachel M Feenstra, Bjarke Njølstad, Pål Rasmus |
| description | A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth. |
| format | Article |
| fullrecord | <record><control><sourceid>cristin_3HK</sourceid><recordid>TN_cdi_cristin_nora_11250_3101598</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11250_3101598</sourcerecordid><originalsourceid>FETCH-cristin_nora_11250_31015983</originalsourceid><addsrcrecordid>eNqNzU0OgjAQBWAWuiDqHcYDkFAJEdbGnwO4J7WdwiQ4Ne0Q4gU8t2BcuHT13uLLe4skVVW-z1Sl6jR5nZH9HbORLIKO0RvSQp4hymCf4B08em2QRfcwIrWdwCRZyBFGsBSF2AhothA7HdBCi4xCBohdPyCbid1QRkT-mZq9w7m1wY_SrZOl033EzTdXyfZ0vB4umQmfi4Z90I1SuzJvCpWrsq6Kf8wbQNhNtw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth</title><source>NORA - Norwegian Open Research Archives</source><creator>Beaumont, Robin N ; Flatley, Christopher ; Vaudel, Marc ; Wu, Xiaoping ; Chen, Jing ; Moen, Gunn-Helen Øiseth ; Skotte, Line ; Helgeland, Øyvind ; Solé-Navais, Pol ; Banasik, Karina ; Albiñana, Clara ; Ronkainen, Justiina ; Fadista, João ; Stinson, Sara Elizabeth ; Trajanoska, Katerina ; Wang, Carol A ; Westergaard, David ; Srinivasan, Sundararajan ; Sánchez-Soriano, Carlos ; Bilbao, Jose Ramon ; Allard, Catherine ; Groleau, Marika ; Kuulasmaa, Teemu ; Leirer, Daniel J ; White, Frédérique ; Jacques, Pierre-Étienne ; Cheng, Haoxiang ; Hao, Ke ; Andreassen, Ole ; Åsvold, Bjørn Olav ; Atalay, Mustafa ; Bhatta, Laxmi ; Bouchard, Luigi ; Brumpton, Ben Michael ; Brunak, Søren ; Bybjerg-Grauholm, Jonas ; Ebbing, Cathrine ; Elliott, Paul ; Engelbrechtsen, Line ; Erikstrup, Christian ; Estarlich, Marisa ; Franks, Stephen ; Gaillard, Romy ; Geller, Frank ; Grove, Jakob ; Hougaard, David M ; Kajantie, Eero Olavi ; Morgen, Camilla S ; Nøhr, Ellen Aagaard ; Nyegaard, Mette ; Palmer, Colin N. A ; Pedersen, Ole Birger ; Rivadeneira, Fernando ; Sebert, Sylvain ; Shields, Beverley M ; Stoltenberg, Camilla ; Surakka, Ida ; Thørner, Lise Wegner ; Ullum, Henrik ; Vaarasmaki, Marja ; Vilhjalmsson, Bjarni J ; Willer, Cristen J ; Lakka, Timo A ; Gybel-Brask, Dorte ; Bustamante, Mariona ; Hansen, Torben ; Pearson, Ewan R ; Reynolds, Rebecca M ; Ostrowski, Sisse R ; Pennell, Craig E ; Jaddoe, Vincent W. V ; Felix, Janine F ; Hattersley, Andrew T ; Melbye, Mads ; Lawlor, Deborah A ; Hveem, Kristian ; Werge, Thomas ; Nielsen, Henriette Svarre ; Magnus, Per Minor ; Evans, David M ; Jacobsson, Bo ; Järvelin, Marjo-Riitta ; Zhang, Ge ; Hivert, Marie-France ; Johansson, Stefan ; Freathy, Rachel M ; Feenstra, Bjarke ; Njølstad, Pål Rasmus</creator><creatorcontrib>Beaumont, Robin N ; Flatley, Christopher ; Vaudel, Marc ; Wu, Xiaoping ; Chen, Jing ; Moen, Gunn-Helen Øiseth ; Skotte, Line ; Helgeland, Øyvind ; Solé-Navais, Pol ; Banasik, Karina ; Albiñana, Clara ; Ronkainen, Justiina ; Fadista, João ; Stinson, Sara Elizabeth ; Trajanoska, Katerina ; Wang, Carol A ; Westergaard, David ; Srinivasan, Sundararajan ; Sánchez-Soriano, Carlos ; Bilbao, Jose Ramon ; Allard, Catherine ; Groleau, Marika ; Kuulasmaa, Teemu ; Leirer, Daniel J ; White, Frédérique ; Jacques, Pierre-Étienne ; Cheng, Haoxiang ; Hao, Ke ; Andreassen, Ole ; Åsvold, Bjørn Olav ; Atalay, Mustafa ; Bhatta, Laxmi ; Bouchard, Luigi ; Brumpton, Ben Michael ; Brunak, Søren ; Bybjerg-Grauholm, Jonas ; Ebbing, Cathrine ; Elliott, Paul ; Engelbrechtsen, Line ; Erikstrup, Christian ; Estarlich, Marisa ; Franks, Stephen ; Gaillard, Romy ; Geller, Frank ; Grove, Jakob ; Hougaard, David M ; Kajantie, Eero Olavi ; Morgen, Camilla S ; Nøhr, Ellen Aagaard ; Nyegaard, Mette ; Palmer, Colin N. A ; Pedersen, Ole Birger ; Rivadeneira, Fernando ; Sebert, Sylvain ; Shields, Beverley M ; Stoltenberg, Camilla ; Surakka, Ida ; Thørner, Lise Wegner ; Ullum, Henrik ; Vaarasmaki, Marja ; Vilhjalmsson, Bjarni J ; Willer, Cristen J ; Lakka, Timo A ; Gybel-Brask, Dorte ; Bustamante, Mariona ; Hansen, Torben ; Pearson, Ewan R ; Reynolds, Rebecca M ; Ostrowski, Sisse R ; Pennell, Craig E ; Jaddoe, Vincent W. V ; Felix, Janine F ; Hattersley, Andrew T ; Melbye, Mads ; Lawlor, Deborah A ; Hveem, Kristian ; Werge, Thomas ; Nielsen, Henriette Svarre ; Magnus, Per Minor ; Evans, David M ; Jacobsson, Bo ; Järvelin, Marjo-Riitta ; Zhang, Ge ; Hivert, Marie-France ; Johansson, Stefan ; Freathy, Rachel M ; Feenstra, Bjarke ; Njølstad, Pål Rasmus</creatorcontrib><description>A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.</description><identifier>ISSN: 1807-1819</identifier><language>eng</language><publisher>Springer Nature Ltd</publisher><creationdate>2023</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,26567</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/11250/3101598$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Beaumont, Robin N</creatorcontrib><creatorcontrib>Flatley, Christopher</creatorcontrib><creatorcontrib>Vaudel, Marc</creatorcontrib><creatorcontrib>Wu, Xiaoping</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Moen, Gunn-Helen Øiseth</creatorcontrib><creatorcontrib>Skotte, Line</creatorcontrib><creatorcontrib>Helgeland, Øyvind</creatorcontrib><creatorcontrib>Solé-Navais, Pol</creatorcontrib><creatorcontrib>Banasik, Karina</creatorcontrib><creatorcontrib>Albiñana, Clara</creatorcontrib><creatorcontrib>Ronkainen, Justiina</creatorcontrib><creatorcontrib>Fadista, João</creatorcontrib><creatorcontrib>Stinson, Sara Elizabeth</creatorcontrib><creatorcontrib>Trajanoska, Katerina</creatorcontrib><creatorcontrib>Wang, Carol A</creatorcontrib><creatorcontrib>Westergaard, David</creatorcontrib><creatorcontrib>Srinivasan, Sundararajan</creatorcontrib><creatorcontrib>Sánchez-Soriano, Carlos</creatorcontrib><creatorcontrib>Bilbao, Jose Ramon</creatorcontrib><creatorcontrib>Allard, Catherine</creatorcontrib><creatorcontrib>Groleau, Marika</creatorcontrib><creatorcontrib>Kuulasmaa, Teemu</creatorcontrib><creatorcontrib>Leirer, Daniel J</creatorcontrib><creatorcontrib>White, Frédérique</creatorcontrib><creatorcontrib>Jacques, Pierre-Étienne</creatorcontrib><creatorcontrib>Cheng, Haoxiang</creatorcontrib><creatorcontrib>Hao, Ke</creatorcontrib><creatorcontrib>Andreassen, Ole</creatorcontrib><creatorcontrib>Åsvold, Bjørn Olav</creatorcontrib><creatorcontrib>Atalay, Mustafa</creatorcontrib><creatorcontrib>Bhatta, Laxmi</creatorcontrib><creatorcontrib>Bouchard, Luigi</creatorcontrib><creatorcontrib>Brumpton, Ben Michael</creatorcontrib><creatorcontrib>Brunak, Søren</creatorcontrib><creatorcontrib>Bybjerg-Grauholm, Jonas</creatorcontrib><creatorcontrib>Ebbing, Cathrine</creatorcontrib><creatorcontrib>Elliott, Paul</creatorcontrib><creatorcontrib>Engelbrechtsen, Line</creatorcontrib><creatorcontrib>Erikstrup, Christian</creatorcontrib><creatorcontrib>Estarlich, Marisa</creatorcontrib><creatorcontrib>Franks, Stephen</creatorcontrib><creatorcontrib>Gaillard, Romy</creatorcontrib><creatorcontrib>Geller, Frank</creatorcontrib><creatorcontrib>Grove, Jakob</creatorcontrib><creatorcontrib>Hougaard, David M</creatorcontrib><creatorcontrib>Kajantie, Eero Olavi</creatorcontrib><creatorcontrib>Morgen, Camilla S</creatorcontrib><creatorcontrib>Nøhr, Ellen Aagaard</creatorcontrib><creatorcontrib>Nyegaard, Mette</creatorcontrib><creatorcontrib>Palmer, Colin N. A</creatorcontrib><creatorcontrib>Pedersen, Ole Birger</creatorcontrib><creatorcontrib>Rivadeneira, Fernando</creatorcontrib><creatorcontrib>Sebert, Sylvain</creatorcontrib><creatorcontrib>Shields, Beverley M</creatorcontrib><creatorcontrib>Stoltenberg, Camilla</creatorcontrib><creatorcontrib>Surakka, Ida</creatorcontrib><creatorcontrib>Thørner, Lise Wegner</creatorcontrib><creatorcontrib>Ullum, Henrik</creatorcontrib><creatorcontrib>Vaarasmaki, Marja</creatorcontrib><creatorcontrib>Vilhjalmsson, Bjarni J</creatorcontrib><creatorcontrib>Willer, Cristen J</creatorcontrib><creatorcontrib>Lakka, Timo A</creatorcontrib><creatorcontrib>Gybel-Brask, Dorte</creatorcontrib><creatorcontrib>Bustamante, Mariona</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Pearson, Ewan R</creatorcontrib><creatorcontrib>Reynolds, Rebecca M</creatorcontrib><creatorcontrib>Ostrowski, Sisse R</creatorcontrib><creatorcontrib>Pennell, Craig E</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V</creatorcontrib><creatorcontrib>Felix, Janine F</creatorcontrib><creatorcontrib>Hattersley, Andrew T</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Lawlor, Deborah A</creatorcontrib><creatorcontrib>Hveem, Kristian</creatorcontrib><creatorcontrib>Werge, Thomas</creatorcontrib><creatorcontrib>Nielsen, Henriette Svarre</creatorcontrib><creatorcontrib>Magnus, Per Minor</creatorcontrib><creatorcontrib>Evans, David M</creatorcontrib><creatorcontrib>Jacobsson, Bo</creatorcontrib><creatorcontrib>Järvelin, Marjo-Riitta</creatorcontrib><creatorcontrib>Zhang, Ge</creatorcontrib><creatorcontrib>Hivert, Marie-France</creatorcontrib><creatorcontrib>Johansson, Stefan</creatorcontrib><creatorcontrib>Freathy, Rachel M</creatorcontrib><creatorcontrib>Feenstra, Bjarke</creatorcontrib><creatorcontrib>Njølstad, Pål Rasmus</creatorcontrib><title>Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth</title><description>A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.</description><issn>1807-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNzU0OgjAQBWAWuiDqHcYDkFAJEdbGnwO4J7WdwiQ4Ne0Q4gU8t2BcuHT13uLLe4skVVW-z1Sl6jR5nZH9HbORLIKO0RvSQp4hymCf4B08em2QRfcwIrWdwCRZyBFGsBSF2AhothA7HdBCi4xCBohdPyCbid1QRkT-mZq9w7m1wY_SrZOl033EzTdXyfZ0vB4umQmfi4Z90I1SuzJvCpWrsq6Kf8wbQNhNtw</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Beaumont, Robin N</creator><creator>Flatley, Christopher</creator><creator>Vaudel, Marc</creator><creator>Wu, Xiaoping</creator><creator>Chen, Jing</creator><creator>Moen, Gunn-Helen Øiseth</creator><creator>Skotte, Line</creator><creator>Helgeland, Øyvind</creator><creator>Solé-Navais, Pol</creator><creator>Banasik, Karina</creator><creator>Albiñana, Clara</creator><creator>Ronkainen, Justiina</creator><creator>Fadista, João</creator><creator>Stinson, Sara Elizabeth</creator><creator>Trajanoska, Katerina</creator><creator>Wang, Carol A</creator><creator>Westergaard, David</creator><creator>Srinivasan, Sundararajan</creator><creator>Sánchez-Soriano, Carlos</creator><creator>Bilbao, Jose Ramon</creator><creator>Allard, Catherine</creator><creator>Groleau, Marika</creator><creator>Kuulasmaa, Teemu</creator><creator>Leirer, Daniel J</creator><creator>White, Frédérique</creator><creator>Jacques, Pierre-Étienne</creator><creator>Cheng, Haoxiang</creator><creator>Hao, Ke</creator><creator>Andreassen, Ole</creator><creator>Åsvold, Bjørn Olav</creator><creator>Atalay, Mustafa</creator><creator>Bhatta, Laxmi</creator><creator>Bouchard, Luigi</creator><creator>Brumpton, Ben Michael</creator><creator>Brunak, Søren</creator><creator>Bybjerg-Grauholm, Jonas</creator><creator>Ebbing, Cathrine</creator><creator>Elliott, Paul</creator><creator>Engelbrechtsen, Line</creator><creator>Erikstrup, Christian</creator><creator>Estarlich, Marisa</creator><creator>Franks, Stephen</creator><creator>Gaillard, Romy</creator><creator>Geller, Frank</creator><creator>Grove, Jakob</creator><creator>Hougaard, David M</creator><creator>Kajantie, Eero Olavi</creator><creator>Morgen, Camilla S</creator><creator>Nøhr, Ellen Aagaard</creator><creator>Nyegaard, Mette</creator><creator>Palmer, Colin N. A</creator><creator>Pedersen, Ole Birger</creator><creator>Rivadeneira, Fernando</creator><creator>Sebert, Sylvain</creator><creator>Shields, Beverley M</creator><creator>Stoltenberg, Camilla</creator><creator>Surakka, Ida</creator><creator>Thørner, Lise Wegner</creator><creator>Ullum, Henrik</creator><creator>Vaarasmaki, Marja</creator><creator>Vilhjalmsson, Bjarni J</creator><creator>Willer, Cristen J</creator><creator>Lakka, Timo A</creator><creator>Gybel-Brask, Dorte</creator><creator>Bustamante, Mariona</creator><creator>Hansen, Torben</creator><creator>Pearson, Ewan R</creator><creator>Reynolds, Rebecca M</creator><creator>Ostrowski, Sisse R</creator><creator>Pennell, Craig E</creator><creator>Jaddoe, Vincent W. V</creator><creator>Felix, Janine F</creator><creator>Hattersley, Andrew T</creator><creator>Melbye, Mads</creator><creator>Lawlor, Deborah A</creator><creator>Hveem, Kristian</creator><creator>Werge, Thomas</creator><creator>Nielsen, Henriette Svarre</creator><creator>Magnus, Per Minor</creator><creator>Evans, David M</creator><creator>Jacobsson, Bo</creator><creator>Järvelin, Marjo-Riitta</creator><creator>Zhang, Ge</creator><creator>Hivert, Marie-France</creator><creator>Johansson, Stefan</creator><creator>Freathy, Rachel M</creator><creator>Feenstra, Bjarke</creator><creator>Njølstad, Pål Rasmus</creator><general>Springer Nature Ltd</general><scope>3HK</scope></search><sort><creationdate>2023</creationdate><title>Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth</title><author>Beaumont, Robin N ; Flatley, Christopher ; Vaudel, Marc ; Wu, Xiaoping ; Chen, Jing ; Moen, Gunn-Helen Øiseth ; Skotte, Line ; Helgeland, Øyvind ; Solé-Navais, Pol ; Banasik, Karina ; Albiñana, Clara ; Ronkainen, Justiina ; Fadista, João ; Stinson, Sara Elizabeth ; Trajanoska, Katerina ; Wang, Carol A ; Westergaard, David ; Srinivasan, Sundararajan ; Sánchez-Soriano, Carlos ; Bilbao, Jose Ramon ; Allard, Catherine ; Groleau, Marika ; Kuulasmaa, Teemu ; Leirer, Daniel J ; White, Frédérique ; Jacques, Pierre-Étienne ; Cheng, Haoxiang ; Hao, Ke ; Andreassen, Ole ; Åsvold, Bjørn Olav ; Atalay, Mustafa ; Bhatta, Laxmi ; Bouchard, Luigi ; Brumpton, Ben Michael ; Brunak, Søren ; Bybjerg-Grauholm, Jonas ; Ebbing, Cathrine ; Elliott, Paul ; Engelbrechtsen, Line ; Erikstrup, Christian ; Estarlich, Marisa ; Franks, Stephen ; Gaillard, Romy ; Geller, Frank ; Grove, Jakob ; Hougaard, David M ; Kajantie, Eero Olavi ; Morgen, Camilla S ; Nøhr, Ellen Aagaard ; Nyegaard, Mette ; Palmer, Colin N. A ; Pedersen, Ole Birger ; Rivadeneira, Fernando ; Sebert, Sylvain ; Shields, Beverley M ; Stoltenberg, Camilla ; Surakka, Ida ; Thørner, Lise Wegner ; Ullum, Henrik ; Vaarasmaki, Marja ; Vilhjalmsson, Bjarni J ; Willer, Cristen J ; Lakka, Timo A ; Gybel-Brask, Dorte ; Bustamante, Mariona ; Hansen, Torben ; Pearson, Ewan R ; Reynolds, Rebecca M ; Ostrowski, Sisse R ; Pennell, Craig E ; Jaddoe, Vincent W. V ; Felix, Janine F ; Hattersley, Andrew T ; Melbye, Mads ; Lawlor, Deborah A ; Hveem, Kristian ; Werge, Thomas ; Nielsen, Henriette Svarre ; Magnus, Per Minor ; Evans, David M ; Jacobsson, Bo ; Järvelin, Marjo-Riitta ; Zhang, Ge ; Hivert, Marie-France ; Johansson, Stefan ; Freathy, Rachel M ; Feenstra, Bjarke ; Njølstad, Pål Rasmus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-cristin_nora_11250_31015983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Beaumont, Robin N</creatorcontrib><creatorcontrib>Flatley, Christopher</creatorcontrib><creatorcontrib>Vaudel, Marc</creatorcontrib><creatorcontrib>Wu, Xiaoping</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Moen, Gunn-Helen Øiseth</creatorcontrib><creatorcontrib>Skotte, Line</creatorcontrib><creatorcontrib>Helgeland, Øyvind</creatorcontrib><creatorcontrib>Solé-Navais, Pol</creatorcontrib><creatorcontrib>Banasik, Karina</creatorcontrib><creatorcontrib>Albiñana, Clara</creatorcontrib><creatorcontrib>Ronkainen, Justiina</creatorcontrib><creatorcontrib>Fadista, João</creatorcontrib><creatorcontrib>Stinson, Sara Elizabeth</creatorcontrib><creatorcontrib>Trajanoska, Katerina</creatorcontrib><creatorcontrib>Wang, Carol A</creatorcontrib><creatorcontrib>Westergaard, David</creatorcontrib><creatorcontrib>Srinivasan, Sundararajan</creatorcontrib><creatorcontrib>Sánchez-Soriano, Carlos</creatorcontrib><creatorcontrib>Bilbao, Jose Ramon</creatorcontrib><creatorcontrib>Allard, Catherine</creatorcontrib><creatorcontrib>Groleau, Marika</creatorcontrib><creatorcontrib>Kuulasmaa, Teemu</creatorcontrib><creatorcontrib>Leirer, Daniel J</creatorcontrib><creatorcontrib>White, Frédérique</creatorcontrib><creatorcontrib>Jacques, Pierre-Étienne</creatorcontrib><creatorcontrib>Cheng, Haoxiang</creatorcontrib><creatorcontrib>Hao, Ke</creatorcontrib><creatorcontrib>Andreassen, Ole</creatorcontrib><creatorcontrib>Åsvold, Bjørn Olav</creatorcontrib><creatorcontrib>Atalay, Mustafa</creatorcontrib><creatorcontrib>Bhatta, Laxmi</creatorcontrib><creatorcontrib>Bouchard, Luigi</creatorcontrib><creatorcontrib>Brumpton, Ben Michael</creatorcontrib><creatorcontrib>Brunak, Søren</creatorcontrib><creatorcontrib>Bybjerg-Grauholm, Jonas</creatorcontrib><creatorcontrib>Ebbing, Cathrine</creatorcontrib><creatorcontrib>Elliott, Paul</creatorcontrib><creatorcontrib>Engelbrechtsen, Line</creatorcontrib><creatorcontrib>Erikstrup, Christian</creatorcontrib><creatorcontrib>Estarlich, Marisa</creatorcontrib><creatorcontrib>Franks, Stephen</creatorcontrib><creatorcontrib>Gaillard, Romy</creatorcontrib><creatorcontrib>Geller, Frank</creatorcontrib><creatorcontrib>Grove, Jakob</creatorcontrib><creatorcontrib>Hougaard, David M</creatorcontrib><creatorcontrib>Kajantie, Eero Olavi</creatorcontrib><creatorcontrib>Morgen, Camilla S</creatorcontrib><creatorcontrib>Nøhr, Ellen Aagaard</creatorcontrib><creatorcontrib>Nyegaard, Mette</creatorcontrib><creatorcontrib>Palmer, Colin N. A</creatorcontrib><creatorcontrib>Pedersen, Ole Birger</creatorcontrib><creatorcontrib>Rivadeneira, Fernando</creatorcontrib><creatorcontrib>Sebert, Sylvain</creatorcontrib><creatorcontrib>Shields, Beverley M</creatorcontrib><creatorcontrib>Stoltenberg, Camilla</creatorcontrib><creatorcontrib>Surakka, Ida</creatorcontrib><creatorcontrib>Thørner, Lise Wegner</creatorcontrib><creatorcontrib>Ullum, Henrik</creatorcontrib><creatorcontrib>Vaarasmaki, Marja</creatorcontrib><creatorcontrib>Vilhjalmsson, Bjarni J</creatorcontrib><creatorcontrib>Willer, Cristen J</creatorcontrib><creatorcontrib>Lakka, Timo A</creatorcontrib><creatorcontrib>Gybel-Brask, Dorte</creatorcontrib><creatorcontrib>Bustamante, Mariona</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Pearson, Ewan R</creatorcontrib><creatorcontrib>Reynolds, Rebecca M</creatorcontrib><creatorcontrib>Ostrowski, Sisse R</creatorcontrib><creatorcontrib>Pennell, Craig E</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V</creatorcontrib><creatorcontrib>Felix, Janine F</creatorcontrib><creatorcontrib>Hattersley, Andrew T</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Lawlor, Deborah A</creatorcontrib><creatorcontrib>Hveem, Kristian</creatorcontrib><creatorcontrib>Werge, Thomas</creatorcontrib><creatorcontrib>Nielsen, Henriette Svarre</creatorcontrib><creatorcontrib>Magnus, Per Minor</creatorcontrib><creatorcontrib>Evans, David M</creatorcontrib><creatorcontrib>Jacobsson, Bo</creatorcontrib><creatorcontrib>Järvelin, Marjo-Riitta</creatorcontrib><creatorcontrib>Zhang, Ge</creatorcontrib><creatorcontrib>Hivert, Marie-France</creatorcontrib><creatorcontrib>Johansson, Stefan</creatorcontrib><creatorcontrib>Freathy, Rachel M</creatorcontrib><creatorcontrib>Feenstra, Bjarke</creatorcontrib><creatorcontrib>Njølstad, Pål Rasmus</creatorcontrib><collection>NORA - Norwegian Open Research Archives</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Beaumont, Robin N</au><au>Flatley, Christopher</au><au>Vaudel, Marc</au><au>Wu, Xiaoping</au><au>Chen, Jing</au><au>Moen, Gunn-Helen Øiseth</au><au>Skotte, Line</au><au>Helgeland, Øyvind</au><au>Solé-Navais, Pol</au><au>Banasik, Karina</au><au>Albiñana, Clara</au><au>Ronkainen, Justiina</au><au>Fadista, João</au><au>Stinson, Sara Elizabeth</au><au>Trajanoska, Katerina</au><au>Wang, Carol A</au><au>Westergaard, David</au><au>Srinivasan, Sundararajan</au><au>Sánchez-Soriano, Carlos</au><au>Bilbao, Jose Ramon</au><au>Allard, Catherine</au><au>Groleau, Marika</au><au>Kuulasmaa, Teemu</au><au>Leirer, Daniel J</au><au>White, Frédérique</au><au>Jacques, Pierre-Étienne</au><au>Cheng, Haoxiang</au><au>Hao, Ke</au><au>Andreassen, Ole</au><au>Åsvold, Bjørn Olav</au><au>Atalay, Mustafa</au><au>Bhatta, Laxmi</au><au>Bouchard, Luigi</au><au>Brumpton, Ben Michael</au><au>Brunak, Søren</au><au>Bybjerg-Grauholm, Jonas</au><au>Ebbing, Cathrine</au><au>Elliott, Paul</au><au>Engelbrechtsen, Line</au><au>Erikstrup, Christian</au><au>Estarlich, Marisa</au><au>Franks, Stephen</au><au>Gaillard, Romy</au><au>Geller, Frank</au><au>Grove, Jakob</au><au>Hougaard, David M</au><au>Kajantie, Eero Olavi</au><au>Morgen, Camilla S</au><au>Nøhr, Ellen Aagaard</au><au>Nyegaard, Mette</au><au>Palmer, Colin N. A</au><au>Pedersen, Ole Birger</au><au>Rivadeneira, Fernando</au><au>Sebert, Sylvain</au><au>Shields, Beverley M</au><au>Stoltenberg, Camilla</au><au>Surakka, Ida</au><au>Thørner, Lise Wegner</au><au>Ullum, Henrik</au><au>Vaarasmaki, Marja</au><au>Vilhjalmsson, Bjarni J</au><au>Willer, Cristen J</au><au>Lakka, Timo A</au><au>Gybel-Brask, Dorte</au><au>Bustamante, Mariona</au><au>Hansen, Torben</au><au>Pearson, Ewan R</au><au>Reynolds, Rebecca M</au><au>Ostrowski, Sisse R</au><au>Pennell, Craig E</au><au>Jaddoe, Vincent W. V</au><au>Felix, Janine F</au><au>Hattersley, Andrew T</au><au>Melbye, Mads</au><au>Lawlor, Deborah A</au><au>Hveem, Kristian</au><au>Werge, Thomas</au><au>Nielsen, Henriette Svarre</au><au>Magnus, Per Minor</au><au>Evans, David M</au><au>Jacobsson, Bo</au><au>Järvelin, Marjo-Riitta</au><au>Zhang, Ge</au><au>Hivert, Marie-France</au><au>Johansson, Stefan</au><au>Freathy, Rachel M</au><au>Feenstra, Bjarke</au><au>Njølstad, Pål Rasmus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth</atitle><date>2023</date><risdate>2023</risdate><issn>1807-1819</issn><abstract>A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.</abstract><pub>Springer Nature Ltd</pub><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1807-1819 |
| ispartof | |
| issn | 1807-1819 |
| language | eng |
| recordid | cdi_cristin_nora_11250_3101598 |
| source | NORA - Norwegian Open Research Archives |
| title | Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T15%3A16%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-cristin_3HK&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genome-wide%20association%20study%20of%20placental%20weight%20identifies%20distinct%20and%20shared%20genetic%20influences%20between%20placental%20and%20fetal%20growth&rft.au=Beaumont,%20Robin%20N&rft.date=2023&rft.issn=1807-1819&rft_id=info:doi/&rft_dat=%3Ccristin_3HK%3E11250_3101598%3C/cristin_3HK%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |