Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic
Background Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic. Methods We analysed a merged cohort of older adul...
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| creator | Polok, Kamil Fronczek, Jakub Guidet, Bertrand Artigas, Antonio De Lange, Dylan W Fjølner, Jesper Leaver, Susannah Beil, Michael Sviri, Sigal Bruno, Raphael Romano Wernly, Bernhard Pinto, Bernardo Bollen Schefold, Joerg C Studzińska, Dorota Joannidis, Michael Oeyen, Sandra Marsh, Brian Andersen, Finn Husøy Moreno, Rui Cecconi, Maurizio Flaatten, Hans Kristian Jung, Christian Szczeklik, Wojciech |
| description | Background
Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic.
Methods
We analysed a merged cohort of older adults admitted to intensive care units (ICUs) due to respiratory failure. Patients were enrolled into one of two prospective observational studies: before COVID-19 (VIP2—2018 to 2019) and admitted due to COVID-19 (COVIP—March 2020 to January 2023). The outcomes included: 30-day mortality, intubation rate and NIV failure (death or intubation within 30 days).
Results
The final cohort included 1986 patients (1292 from VIP2, 694 from COVIP) with a median age of 83 years. NIV was used as a primary mode of respiratory support in 697 participants (35.1%). ICU admission due to COVID-19 was associated with an increased 30-day mortality (65.5% vs. 36.5%, HR 2.18, 95% CI 1.71 to 2.77), more frequent intubation (36.9% vs. 17.5%, OR 2.63, 95% CI 1.74 to 3.99) and NIV failure (76.2% vs. 45.3%, OR 4.21, 95% CI 2.84 to 6.34) compared to non-COVID causes of respiratory failure. Sensitivity analysis after exclusion of patients in whom life supporting treatment limitation was introduced during primary NIV confirmed higher 30-day mortality in patients with COVID-19 (52.5% vs. 23.4%, HR 2.64, 95% CI 1.83 to 3.80).
Conclusion
The outcomes of patients aged ≥80 years treated with NIV during COVID-19 pandemic were worse compared then those treated with NIV in the pre-pandemic era. |
| format | Article |
| fullrecord | <record><control><sourceid>cristin_3HK</sourceid><recordid>TN_cdi_cristin_nora_11250_3097472</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11250_3097472</sourcerecordid><originalsourceid>FETCH-cristin_nora_11250_30974723</originalsourceid><addsrcrecordid>eNqNjk1uwkAMhbNhgdrewT1ApIQfUdb8qKzYILaRSRxqafBEHk9QjsBBeoLeiJMwRT1AV35P-t4nj7OffbTaXyiAb6FDYxILgGdq4H77_ihgINQAV7YvUAodK5rXAVpkF5WAhY3RuQFMCS3Nnqh4yVl6DNwT9MnJLrm9JB42UX1H-JuN5EnUmFQxqQKcqPWpoDTQRGU5w2p_3K3zcpnek4YuXL9moxZdoLe_-5K9bzeH1WdeKwdjqcQrVmU5mRfVtFguZovJ9D_MA0B5XHo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic</title><source>NORA - Norwegian Open Research Archives</source><creator>Polok, Kamil ; Fronczek, Jakub ; Guidet, Bertrand ; Artigas, Antonio ; De Lange, Dylan W ; Fjølner, Jesper ; Leaver, Susannah ; Beil, Michael ; Sviri, Sigal ; Bruno, Raphael Romano ; Wernly, Bernhard ; Pinto, Bernardo Bollen ; Schefold, Joerg C ; Studzińska, Dorota ; Joannidis, Michael ; Oeyen, Sandra ; Marsh, Brian ; Andersen, Finn Husøy ; Moreno, Rui ; Cecconi, Maurizio ; Flaatten, Hans Kristian ; Jung, Christian ; Szczeklik, Wojciech</creator><creatorcontrib>Polok, Kamil ; Fronczek, Jakub ; Guidet, Bertrand ; Artigas, Antonio ; De Lange, Dylan W ; Fjølner, Jesper ; Leaver, Susannah ; Beil, Michael ; Sviri, Sigal ; Bruno, Raphael Romano ; Wernly, Bernhard ; Pinto, Bernardo Bollen ; Schefold, Joerg C ; Studzińska, Dorota ; Joannidis, Michael ; Oeyen, Sandra ; Marsh, Brian ; Andersen, Finn Husøy ; Moreno, Rui ; Cecconi, Maurizio ; Flaatten, Hans Kristian ; Jung, Christian ; Szczeklik, Wojciech</creatorcontrib><description>Background
Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic.
Methods
We analysed a merged cohort of older adults admitted to intensive care units (ICUs) due to respiratory failure. Patients were enrolled into one of two prospective observational studies: before COVID-19 (VIP2—2018 to 2019) and admitted due to COVID-19 (COVIP—March 2020 to January 2023). The outcomes included: 30-day mortality, intubation rate and NIV failure (death or intubation within 30 days).
Results
The final cohort included 1986 patients (1292 from VIP2, 694 from COVIP) with a median age of 83 years. NIV was used as a primary mode of respiratory support in 697 participants (35.1%). ICU admission due to COVID-19 was associated with an increased 30-day mortality (65.5% vs. 36.5%, HR 2.18, 95% CI 1.71 to 2.77), more frequent intubation (36.9% vs. 17.5%, OR 2.63, 95% CI 1.74 to 3.99) and NIV failure (76.2% vs. 45.3%, OR 4.21, 95% CI 2.84 to 6.34) compared to non-COVID causes of respiratory failure. Sensitivity analysis after exclusion of patients in whom life supporting treatment limitation was introduced during primary NIV confirmed higher 30-day mortality in patients with COVID-19 (52.5% vs. 23.4%, HR 2.64, 95% CI 1.83 to 3.80).
Conclusion
The outcomes of patients aged ≥80 years treated with NIV during COVID-19 pandemic were worse compared then those treated with NIV in the pre-pandemic era.</description><language>eng</language><publisher>Springer</publisher><creationdate>2023</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,26567</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/11250/3097472$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Polok, Kamil</creatorcontrib><creatorcontrib>Fronczek, Jakub</creatorcontrib><creatorcontrib>Guidet, Bertrand</creatorcontrib><creatorcontrib>Artigas, Antonio</creatorcontrib><creatorcontrib>De Lange, Dylan W</creatorcontrib><creatorcontrib>Fjølner, Jesper</creatorcontrib><creatorcontrib>Leaver, Susannah</creatorcontrib><creatorcontrib>Beil, Michael</creatorcontrib><creatorcontrib>Sviri, Sigal</creatorcontrib><creatorcontrib>Bruno, Raphael Romano</creatorcontrib><creatorcontrib>Wernly, Bernhard</creatorcontrib><creatorcontrib>Pinto, Bernardo Bollen</creatorcontrib><creatorcontrib>Schefold, Joerg C</creatorcontrib><creatorcontrib>Studzińska, Dorota</creatorcontrib><creatorcontrib>Joannidis, Michael</creatorcontrib><creatorcontrib>Oeyen, Sandra</creatorcontrib><creatorcontrib>Marsh, Brian</creatorcontrib><creatorcontrib>Andersen, Finn Husøy</creatorcontrib><creatorcontrib>Moreno, Rui</creatorcontrib><creatorcontrib>Cecconi, Maurizio</creatorcontrib><creatorcontrib>Flaatten, Hans Kristian</creatorcontrib><creatorcontrib>Jung, Christian</creatorcontrib><creatorcontrib>Szczeklik, Wojciech</creatorcontrib><title>Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic</title><description>Background
Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic.
Methods
We analysed a merged cohort of older adults admitted to intensive care units (ICUs) due to respiratory failure. Patients were enrolled into one of two prospective observational studies: before COVID-19 (VIP2—2018 to 2019) and admitted due to COVID-19 (COVIP—March 2020 to January 2023). The outcomes included: 30-day mortality, intubation rate and NIV failure (death or intubation within 30 days).
Results
The final cohort included 1986 patients (1292 from VIP2, 694 from COVIP) with a median age of 83 years. NIV was used as a primary mode of respiratory support in 697 participants (35.1%). ICU admission due to COVID-19 was associated with an increased 30-day mortality (65.5% vs. 36.5%, HR 2.18, 95% CI 1.71 to 2.77), more frequent intubation (36.9% vs. 17.5%, OR 2.63, 95% CI 1.74 to 3.99) and NIV failure (76.2% vs. 45.3%, OR 4.21, 95% CI 2.84 to 6.34) compared to non-COVID causes of respiratory failure. Sensitivity analysis after exclusion of patients in whom life supporting treatment limitation was introduced during primary NIV confirmed higher 30-day mortality in patients with COVID-19 (52.5% vs. 23.4%, HR 2.64, 95% CI 1.83 to 3.80).
Conclusion
The outcomes of patients aged ≥80 years treated with NIV during COVID-19 pandemic were worse compared then those treated with NIV in the pre-pandemic era.</description><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNjk1uwkAMhbNhgdrewT1ApIQfUdb8qKzYILaRSRxqafBEHk9QjsBBeoLeiJMwRT1AV35P-t4nj7OffbTaXyiAb6FDYxILgGdq4H77_ihgINQAV7YvUAodK5rXAVpkF5WAhY3RuQFMCS3Nnqh4yVl6DNwT9MnJLrm9JB42UX1H-JuN5EnUmFQxqQKcqPWpoDTQRGU5w2p_3K3zcpnek4YuXL9moxZdoLe_-5K9bzeH1WdeKwdjqcQrVmU5mRfVtFguZovJ9D_MA0B5XHo</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Polok, Kamil</creator><creator>Fronczek, Jakub</creator><creator>Guidet, Bertrand</creator><creator>Artigas, Antonio</creator><creator>De Lange, Dylan W</creator><creator>Fjølner, Jesper</creator><creator>Leaver, Susannah</creator><creator>Beil, Michael</creator><creator>Sviri, Sigal</creator><creator>Bruno, Raphael Romano</creator><creator>Wernly, Bernhard</creator><creator>Pinto, Bernardo Bollen</creator><creator>Schefold, Joerg C</creator><creator>Studzińska, Dorota</creator><creator>Joannidis, Michael</creator><creator>Oeyen, Sandra</creator><creator>Marsh, Brian</creator><creator>Andersen, Finn Husøy</creator><creator>Moreno, Rui</creator><creator>Cecconi, Maurizio</creator><creator>Flaatten, Hans Kristian</creator><creator>Jung, Christian</creator><creator>Szczeklik, Wojciech</creator><general>Springer</general><scope>3HK</scope></search><sort><creationdate>2023</creationdate><title>Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic</title><author>Polok, Kamil ; Fronczek, Jakub ; Guidet, Bertrand ; Artigas, Antonio ; De Lange, Dylan W ; Fjølner, Jesper ; Leaver, Susannah ; Beil, Michael ; Sviri, Sigal ; Bruno, Raphael Romano ; Wernly, Bernhard ; Pinto, Bernardo Bollen ; Schefold, Joerg C ; Studzińska, Dorota ; Joannidis, Michael ; Oeyen, Sandra ; Marsh, Brian ; Andersen, Finn Husøy ; Moreno, Rui ; Cecconi, Maurizio ; Flaatten, Hans Kristian ; Jung, Christian ; Szczeklik, Wojciech</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-cristin_nora_11250_30974723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Polok, Kamil</creatorcontrib><creatorcontrib>Fronczek, Jakub</creatorcontrib><creatorcontrib>Guidet, Bertrand</creatorcontrib><creatorcontrib>Artigas, Antonio</creatorcontrib><creatorcontrib>De Lange, Dylan W</creatorcontrib><creatorcontrib>Fjølner, Jesper</creatorcontrib><creatorcontrib>Leaver, Susannah</creatorcontrib><creatorcontrib>Beil, Michael</creatorcontrib><creatorcontrib>Sviri, Sigal</creatorcontrib><creatorcontrib>Bruno, Raphael Romano</creatorcontrib><creatorcontrib>Wernly, Bernhard</creatorcontrib><creatorcontrib>Pinto, Bernardo Bollen</creatorcontrib><creatorcontrib>Schefold, Joerg C</creatorcontrib><creatorcontrib>Studzińska, Dorota</creatorcontrib><creatorcontrib>Joannidis, Michael</creatorcontrib><creatorcontrib>Oeyen, Sandra</creatorcontrib><creatorcontrib>Marsh, Brian</creatorcontrib><creatorcontrib>Andersen, Finn Husøy</creatorcontrib><creatorcontrib>Moreno, Rui</creatorcontrib><creatorcontrib>Cecconi, Maurizio</creatorcontrib><creatorcontrib>Flaatten, Hans Kristian</creatorcontrib><creatorcontrib>Jung, Christian</creatorcontrib><creatorcontrib>Szczeklik, Wojciech</creatorcontrib><collection>NORA - Norwegian Open Research Archives</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Polok, Kamil</au><au>Fronczek, Jakub</au><au>Guidet, Bertrand</au><au>Artigas, Antonio</au><au>De Lange, Dylan W</au><au>Fjølner, Jesper</au><au>Leaver, Susannah</au><au>Beil, Michael</au><au>Sviri, Sigal</au><au>Bruno, Raphael Romano</au><au>Wernly, Bernhard</au><au>Pinto, Bernardo Bollen</au><au>Schefold, Joerg C</au><au>Studzińska, Dorota</au><au>Joannidis, Michael</au><au>Oeyen, Sandra</au><au>Marsh, Brian</au><au>Andersen, Finn Husøy</au><au>Moreno, Rui</au><au>Cecconi, Maurizio</au><au>Flaatten, Hans Kristian</au><au>Jung, Christian</au><au>Szczeklik, Wojciech</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic</atitle><date>2023</date><risdate>2023</risdate><abstract>Background
Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic.
Methods
We analysed a merged cohort of older adults admitted to intensive care units (ICUs) due to respiratory failure. Patients were enrolled into one of two prospective observational studies: before COVID-19 (VIP2—2018 to 2019) and admitted due to COVID-19 (COVIP—March 2020 to January 2023). The outcomes included: 30-day mortality, intubation rate and NIV failure (death or intubation within 30 days).
Results
The final cohort included 1986 patients (1292 from VIP2, 694 from COVIP) with a median age of 83 years. NIV was used as a primary mode of respiratory support in 697 participants (35.1%). ICU admission due to COVID-19 was associated with an increased 30-day mortality (65.5% vs. 36.5%, HR 2.18, 95% CI 1.71 to 2.77), more frequent intubation (36.9% vs. 17.5%, OR 2.63, 95% CI 1.74 to 3.99) and NIV failure (76.2% vs. 45.3%, OR 4.21, 95% CI 2.84 to 6.34) compared to non-COVID causes of respiratory failure. Sensitivity analysis after exclusion of patients in whom life supporting treatment limitation was introduced during primary NIV confirmed higher 30-day mortality in patients with COVID-19 (52.5% vs. 23.4%, HR 2.64, 95% CI 1.83 to 3.80).
Conclusion
The outcomes of patients aged ≥80 years treated with NIV during COVID-19 pandemic were worse compared then those treated with NIV in the pre-pandemic era.</abstract><pub>Springer</pub><oa>free_for_read</oa></addata></record> |
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| title | Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic |
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