Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for indivi...
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| creator | Cusi, Daniele Li, Man Scholz, Markus van der Most, Peter J Yang, Qiong Nutile, Teresa Günther, Felix De Grandi, Alessandro Franke, Andre Metspalu, Andres Hicks, Andrew A Tönjes, Anke Podgornaia, Anna I Spedicati, Beatrice Ponte, Belen Schöttker, Ben Banas, Bernhard Smith, Blair H Spracklen, Cassandra N Fuchsberger, Christian Shaffer, Christian M Gudbjartsson, Daniel F Czamara, Darina Porteous, David J Waterworth, Dawn M Mascalzoni, Deborah Reilly, Dermot F Salvi, Erika Guo, Feng Sveinbjornsson, Gardar Ehret, Georg Nadkarni, Girish N Snieder, Harold Campbell, Harry Brenner, Hermann Kramer, Holly Halbritter, Jan Rotter, Jerome I Thiery, Joachim Ärnlöv, Johan Tremblay, Johanne Whitfield, John B Gaziano, John M Coresh, Josef Eckardt, Kai-Uwe Ryan, Kathleen A Taylor, Kent D Nikus, Kjell Matsuda, Koichi Wallentin, Lars Phillips, Lawrence S Klaric, Lucija Kleber, Marcus E Orho-Melander, Marju Laakso, Markku de Borst, Martin H Lukas, Mary Ann Wojczynski, Mary K Kavousi, Maryam Akiyama, Masato Yasuda, Masayuki Chee, Miao-Li Chee, Miao-Ling Boehnke, Michael Preuss, Michael H Stumvoll, Michael Evans, Michele K Kastarinen, Mika Nalls, Mike A Hutri-Kähönen, Nina Raitakari, Olli T Sulem, Patrick Magnusson, Patrik K. E Rossing, Peter Vollenweider, Peter Carroll, Robert J Felicita, Sala Cinzia Sedaghat, Sanaz Padmanabhan, Sandosh Pendergrass, Sarah A Graham, Sarah E Vaccargiu, Simona Lim, Su-Chi Vogelezang, Suzanne Corre, Tanguy Ahluwalia, Tarunveer S Boutin, Thibaud S Meitinger, Thomas Völker, Uwe Salomaa, Veikko Jaddoe, Vincent W. V Wei, Wen Bin Kiess, Wieland März, Winfried Sim, Xueling Okada, Yukinori Milaneschi, Yuri Yu, Zhi Stark, Klaus J Köttgen, Anna |
| description | Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM. |
| format | Article |
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E ; Rossing, Peter ; Vollenweider, Peter ; Carroll, Robert J ; Felicita, Sala Cinzia ; Sedaghat, Sanaz ; Padmanabhan, Sandosh ; Pendergrass, Sarah A ; Graham, Sarah E ; Vaccargiu, Simona ; Lim, Su-Chi ; Vogelezang, Suzanne ; Corre, Tanguy ; Ahluwalia, Tarunveer S ; Boutin, Thibaud S ; Meitinger, Thomas ; Völker, Uwe ; Salomaa, Veikko ; Jaddoe, Vincent W. V ; Wei, Wen Bin ; Kiess, Wieland ; März, Winfried ; Sim, Xueling ; Okada, Yukinori ; Milaneschi, Yuri ; Yu, Zhi ; Stark, Klaus J ; Köttgen, Anna</creator><creatorcontrib>Cusi, Daniele ; Li, Man ; Scholz, Markus ; van der Most, Peter J ; Yang, Qiong ; Nutile, Teresa ; Günther, Felix ; De Grandi, Alessandro ; Franke, Andre ; Metspalu, Andres ; Hicks, Andrew A ; Tönjes, Anke ; Podgornaia, Anna I ; Spedicati, Beatrice ; Ponte, Belen ; Schöttker, Ben ; Banas, Bernhard ; Smith, Blair H ; Spracklen, Cassandra N ; Fuchsberger, Christian ; Shaffer, Christian M ; Gudbjartsson, Daniel F ; Czamara, Darina ; Porteous, David J ; Waterworth, Dawn M ; Mascalzoni, Deborah ; Reilly, Dermot F ; Salvi, Erika ; Guo, Feng ; Sveinbjornsson, Gardar ; Ehret, Georg ; Nadkarni, Girish N ; Snieder, Harold ; Campbell, Harry ; Brenner, Hermann ; Kramer, Holly ; Halbritter, Jan ; Rotter, Jerome I ; Thiery, Joachim ; Ärnlöv, Johan ; Tremblay, Johanne ; Whitfield, John B ; Gaziano, John M ; Coresh, Josef ; Eckardt, Kai-Uwe ; Ryan, Kathleen A ; Taylor, Kent D ; Nikus, Kjell ; Matsuda, Koichi ; Wallentin, Lars ; Phillips, Lawrence S ; Klaric, Lucija ; Kleber, Marcus E ; Orho-Melander, Marju ; Laakso, Markku ; de Borst, Martin H ; Lukas, Mary Ann ; Wojczynski, Mary K ; Kavousi, Maryam ; Akiyama, Masato ; Yasuda, Masayuki ; Chee, Miao-Li ; Chee, Miao-Ling ; Boehnke, Michael ; Preuss, Michael H ; Stumvoll, Michael ; Evans, Michele K ; Kastarinen, Mika ; Nalls, Mike A ; Hutri-Kähönen, Nina ; Raitakari, Olli T ; Sulem, Patrick ; Magnusson, Patrik K. E ; Rossing, Peter ; Vollenweider, Peter ; Carroll, Robert J ; Felicita, Sala Cinzia ; Sedaghat, Sanaz ; Padmanabhan, Sandosh ; Pendergrass, Sarah A ; Graham, Sarah E ; Vaccargiu, Simona ; Lim, Su-Chi ; Vogelezang, Suzanne ; Corre, Tanguy ; Ahluwalia, Tarunveer S ; Boutin, Thibaud S ; Meitinger, Thomas ; Völker, Uwe ; Salomaa, Veikko ; Jaddoe, Vincent W. V ; Wei, Wen Bin ; Kiess, Wieland ; März, Winfried ; Sim, Xueling ; Okada, Yukinori ; Milaneschi, Yuri ; Yu, Zhi ; Stark, Klaus J ; Köttgen, Anna</creatorcontrib><description>Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.</description><language>eng</language><publisher>Nature</publisher><creationdate>2022</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,26544</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/11250/3047490$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Cusi, Daniele</creatorcontrib><creatorcontrib>Li, Man</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>van der Most, Peter J</creatorcontrib><creatorcontrib>Yang, Qiong</creatorcontrib><creatorcontrib>Nutile, Teresa</creatorcontrib><creatorcontrib>Günther, Felix</creatorcontrib><creatorcontrib>De Grandi, Alessandro</creatorcontrib><creatorcontrib>Franke, Andre</creatorcontrib><creatorcontrib>Metspalu, Andres</creatorcontrib><creatorcontrib>Hicks, Andrew A</creatorcontrib><creatorcontrib>Tönjes, Anke</creatorcontrib><creatorcontrib>Podgornaia, Anna I</creatorcontrib><creatorcontrib>Spedicati, Beatrice</creatorcontrib><creatorcontrib>Ponte, Belen</creatorcontrib><creatorcontrib>Schöttker, Ben</creatorcontrib><creatorcontrib>Banas, Bernhard</creatorcontrib><creatorcontrib>Smith, Blair H</creatorcontrib><creatorcontrib>Spracklen, Cassandra N</creatorcontrib><creatorcontrib>Fuchsberger, Christian</creatorcontrib><creatorcontrib>Shaffer, Christian M</creatorcontrib><creatorcontrib>Gudbjartsson, Daniel F</creatorcontrib><creatorcontrib>Czamara, Darina</creatorcontrib><creatorcontrib>Porteous, David J</creatorcontrib><creatorcontrib>Waterworth, Dawn M</creatorcontrib><creatorcontrib>Mascalzoni, Deborah</creatorcontrib><creatorcontrib>Reilly, Dermot F</creatorcontrib><creatorcontrib>Salvi, Erika</creatorcontrib><creatorcontrib>Guo, Feng</creatorcontrib><creatorcontrib>Sveinbjornsson, Gardar</creatorcontrib><creatorcontrib>Ehret, Georg</creatorcontrib><creatorcontrib>Nadkarni, Girish N</creatorcontrib><creatorcontrib>Snieder, Harold</creatorcontrib><creatorcontrib>Campbell, Harry</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><creatorcontrib>Kramer, Holly</creatorcontrib><creatorcontrib>Halbritter, Jan</creatorcontrib><creatorcontrib>Rotter, Jerome I</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Ärnlöv, Johan</creatorcontrib><creatorcontrib>Tremblay, Johanne</creatorcontrib><creatorcontrib>Whitfield, John B</creatorcontrib><creatorcontrib>Gaziano, John M</creatorcontrib><creatorcontrib>Coresh, Josef</creatorcontrib><creatorcontrib>Eckardt, Kai-Uwe</creatorcontrib><creatorcontrib>Ryan, Kathleen A</creatorcontrib><creatorcontrib>Taylor, Kent D</creatorcontrib><creatorcontrib>Nikus, Kjell</creatorcontrib><creatorcontrib>Matsuda, Koichi</creatorcontrib><creatorcontrib>Wallentin, Lars</creatorcontrib><creatorcontrib>Phillips, Lawrence S</creatorcontrib><creatorcontrib>Klaric, Lucija</creatorcontrib><creatorcontrib>Kleber, Marcus E</creatorcontrib><creatorcontrib>Orho-Melander, Marju</creatorcontrib><creatorcontrib>Laakso, Markku</creatorcontrib><creatorcontrib>de Borst, Martin H</creatorcontrib><creatorcontrib>Lukas, Mary Ann</creatorcontrib><creatorcontrib>Wojczynski, Mary K</creatorcontrib><creatorcontrib>Kavousi, Maryam</creatorcontrib><creatorcontrib>Akiyama, Masato</creatorcontrib><creatorcontrib>Yasuda, Masayuki</creatorcontrib><creatorcontrib>Chee, Miao-Li</creatorcontrib><creatorcontrib>Chee, Miao-Ling</creatorcontrib><creatorcontrib>Boehnke, Michael</creatorcontrib><creatorcontrib>Preuss, Michael H</creatorcontrib><creatorcontrib>Stumvoll, Michael</creatorcontrib><creatorcontrib>Evans, Michele K</creatorcontrib><creatorcontrib>Kastarinen, Mika</creatorcontrib><creatorcontrib>Nalls, Mike A</creatorcontrib><creatorcontrib>Hutri-Kähönen, Nina</creatorcontrib><creatorcontrib>Raitakari, Olli T</creatorcontrib><creatorcontrib>Sulem, Patrick</creatorcontrib><creatorcontrib>Magnusson, Patrik K. E</creatorcontrib><creatorcontrib>Rossing, Peter</creatorcontrib><creatorcontrib>Vollenweider, Peter</creatorcontrib><creatorcontrib>Carroll, Robert J</creatorcontrib><creatorcontrib>Felicita, Sala Cinzia</creatorcontrib><creatorcontrib>Sedaghat, Sanaz</creatorcontrib><creatorcontrib>Padmanabhan, Sandosh</creatorcontrib><creatorcontrib>Pendergrass, Sarah A</creatorcontrib><creatorcontrib>Graham, Sarah E</creatorcontrib><creatorcontrib>Vaccargiu, Simona</creatorcontrib><creatorcontrib>Lim, Su-Chi</creatorcontrib><creatorcontrib>Vogelezang, Suzanne</creatorcontrib><creatorcontrib>Corre, Tanguy</creatorcontrib><creatorcontrib>Ahluwalia, Tarunveer S</creatorcontrib><creatorcontrib>Boutin, Thibaud S</creatorcontrib><creatorcontrib>Meitinger, Thomas</creatorcontrib><creatorcontrib>Völker, Uwe</creatorcontrib><creatorcontrib>Salomaa, Veikko</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V</creatorcontrib><creatorcontrib>Wei, Wen Bin</creatorcontrib><creatorcontrib>Kiess, Wieland</creatorcontrib><creatorcontrib>März, Winfried</creatorcontrib><creatorcontrib>Sim, Xueling</creatorcontrib><creatorcontrib>Okada, Yukinori</creatorcontrib><creatorcontrib>Milaneschi, Yuri</creatorcontrib><creatorcontrib>Yu, Zhi</creatorcontrib><creatorcontrib>Stark, Klaus J</creatorcontrib><creatorcontrib>Köttgen, Anna</creatorcontrib><title>Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals</title><description>Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.</description><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNi00KwjAQhbNxIeodxgMUUlsprv3BA7gPaTKxg2UCyVTx9kYR164-3nvfm6vhQCFgQhayI1j2kAeb0MMVGYUcYJmdZIgMN_KMTwgTO6GSe5QHIoMn23_c950jV7-C2NOd_GTHvFSzUICrLxdqfTpe9ufKJcpCbDgma-p6s9Wm0W3X7nTzj_MC-LNACQ</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Cusi, Daniele</creator><creator>Li, Man</creator><creator>Scholz, Markus</creator><creator>van der Most, Peter J</creator><creator>Yang, Qiong</creator><creator>Nutile, Teresa</creator><creator>Günther, Felix</creator><creator>De Grandi, Alessandro</creator><creator>Franke, Andre</creator><creator>Metspalu, Andres</creator><creator>Hicks, Andrew A</creator><creator>Tönjes, Anke</creator><creator>Podgornaia, Anna I</creator><creator>Spedicati, Beatrice</creator><creator>Ponte, Belen</creator><creator>Schöttker, Ben</creator><creator>Banas, Bernhard</creator><creator>Smith, Blair H</creator><creator>Spracklen, Cassandra N</creator><creator>Fuchsberger, Christian</creator><creator>Shaffer, Christian M</creator><creator>Gudbjartsson, Daniel F</creator><creator>Czamara, Darina</creator><creator>Porteous, David J</creator><creator>Waterworth, Dawn M</creator><creator>Mascalzoni, Deborah</creator><creator>Reilly, Dermot F</creator><creator>Salvi, Erika</creator><creator>Guo, Feng</creator><creator>Sveinbjornsson, Gardar</creator><creator>Ehret, Georg</creator><creator>Nadkarni, Girish N</creator><creator>Snieder, Harold</creator><creator>Campbell, Harry</creator><creator>Brenner, Hermann</creator><creator>Kramer, Holly</creator><creator>Halbritter, Jan</creator><creator>Rotter, Jerome I</creator><creator>Thiery, Joachim</creator><creator>Ärnlöv, Johan</creator><creator>Tremblay, Johanne</creator><creator>Whitfield, John B</creator><creator>Gaziano, John M</creator><creator>Coresh, Josef</creator><creator>Eckardt, Kai-Uwe</creator><creator>Ryan, Kathleen A</creator><creator>Taylor, Kent D</creator><creator>Nikus, Kjell</creator><creator>Matsuda, Koichi</creator><creator>Wallentin, Lars</creator><creator>Phillips, Lawrence S</creator><creator>Klaric, Lucija</creator><creator>Kleber, Marcus E</creator><creator>Orho-Melander, Marju</creator><creator>Laakso, Markku</creator><creator>de Borst, Martin H</creator><creator>Lukas, Mary Ann</creator><creator>Wojczynski, Mary K</creator><creator>Kavousi, Maryam</creator><creator>Akiyama, Masato</creator><creator>Yasuda, Masayuki</creator><creator>Chee, Miao-Li</creator><creator>Chee, Miao-Ling</creator><creator>Boehnke, Michael</creator><creator>Preuss, Michael H</creator><creator>Stumvoll, Michael</creator><creator>Evans, Michele K</creator><creator>Kastarinen, Mika</creator><creator>Nalls, Mike A</creator><creator>Hutri-Kähönen, Nina</creator><creator>Raitakari, Olli T</creator><creator>Sulem, Patrick</creator><creator>Magnusson, Patrik K. E</creator><creator>Rossing, Peter</creator><creator>Vollenweider, Peter</creator><creator>Carroll, Robert J</creator><creator>Felicita, Sala Cinzia</creator><creator>Sedaghat, Sanaz</creator><creator>Padmanabhan, Sandosh</creator><creator>Pendergrass, Sarah A</creator><creator>Graham, Sarah E</creator><creator>Vaccargiu, Simona</creator><creator>Lim, Su-Chi</creator><creator>Vogelezang, Suzanne</creator><creator>Corre, Tanguy</creator><creator>Ahluwalia, Tarunveer S</creator><creator>Boutin, Thibaud S</creator><creator>Meitinger, Thomas</creator><creator>Völker, Uwe</creator><creator>Salomaa, Veikko</creator><creator>Jaddoe, Vincent W. V</creator><creator>Wei, Wen Bin</creator><creator>Kiess, Wieland</creator><creator>März, Winfried</creator><creator>Sim, Xueling</creator><creator>Okada, Yukinori</creator><creator>Milaneschi, Yuri</creator><creator>Yu, Zhi</creator><creator>Stark, Klaus J</creator><creator>Köttgen, Anna</creator><general>Nature</general><scope>3HK</scope></search><sort><creationdate>2022</creationdate><title>Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals</title><author>Cusi, Daniele ; Li, Man ; Scholz, Markus ; van der Most, Peter J ; Yang, Qiong ; Nutile, Teresa ; Günther, Felix ; De Grandi, Alessandro ; Franke, Andre ; Metspalu, Andres ; Hicks, Andrew A ; Tönjes, Anke ; Podgornaia, Anna I ; Spedicati, Beatrice ; Ponte, Belen ; Schöttker, Ben ; Banas, Bernhard ; Smith, Blair H ; Spracklen, Cassandra N ; Fuchsberger, Christian ; Shaffer, Christian M ; Gudbjartsson, Daniel F ; Czamara, Darina ; Porteous, David J ; Waterworth, Dawn M ; Mascalzoni, Deborah ; Reilly, Dermot F ; Salvi, Erika ; Guo, Feng ; Sveinbjornsson, Gardar ; Ehret, Georg ; Nadkarni, Girish N ; Snieder, Harold ; Campbell, Harry ; Brenner, Hermann ; Kramer, Holly ; Halbritter, Jan ; Rotter, Jerome I ; Thiery, Joachim ; Ärnlöv, Johan ; Tremblay, Johanne ; Whitfield, John B ; Gaziano, John M ; Coresh, Josef ; Eckardt, Kai-Uwe ; Ryan, Kathleen A ; Taylor, Kent D ; Nikus, Kjell ; Matsuda, Koichi ; Wallentin, Lars ; Phillips, Lawrence S ; Klaric, Lucija ; Kleber, Marcus E ; Orho-Melander, Marju ; Laakso, Markku ; de Borst, Martin H ; Lukas, Mary Ann ; Wojczynski, Mary K ; Kavousi, Maryam ; Akiyama, Masato ; Yasuda, Masayuki ; Chee, Miao-Li ; Chee, Miao-Ling ; Boehnke, Michael ; Preuss, Michael H ; Stumvoll, Michael ; Evans, Michele K ; Kastarinen, Mika ; Nalls, Mike A ; Hutri-Kähönen, Nina ; Raitakari, Olli T ; Sulem, Patrick ; Magnusson, Patrik K. E ; Rossing, Peter ; Vollenweider, Peter ; Carroll, Robert J ; Felicita, Sala Cinzia ; Sedaghat, Sanaz ; Padmanabhan, Sandosh ; Pendergrass, Sarah A ; Graham, Sarah E ; Vaccargiu, Simona ; Lim, Su-Chi ; Vogelezang, Suzanne ; Corre, Tanguy ; Ahluwalia, Tarunveer S ; Boutin, Thibaud S ; Meitinger, Thomas ; Völker, Uwe ; Salomaa, Veikko ; Jaddoe, Vincent W. V ; Wei, Wen Bin ; Kiess, Wieland ; März, Winfried ; Sim, Xueling ; Okada, Yukinori ; Milaneschi, Yuri ; Yu, Zhi ; Stark, Klaus J ; Köttgen, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-cristin_nora_11250_30474903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Cusi, Daniele</creatorcontrib><creatorcontrib>Li, Man</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>van der Most, Peter J</creatorcontrib><creatorcontrib>Yang, Qiong</creatorcontrib><creatorcontrib>Nutile, Teresa</creatorcontrib><creatorcontrib>Günther, Felix</creatorcontrib><creatorcontrib>De Grandi, Alessandro</creatorcontrib><creatorcontrib>Franke, Andre</creatorcontrib><creatorcontrib>Metspalu, Andres</creatorcontrib><creatorcontrib>Hicks, Andrew A</creatorcontrib><creatorcontrib>Tönjes, Anke</creatorcontrib><creatorcontrib>Podgornaia, Anna I</creatorcontrib><creatorcontrib>Spedicati, Beatrice</creatorcontrib><creatorcontrib>Ponte, Belen</creatorcontrib><creatorcontrib>Schöttker, Ben</creatorcontrib><creatorcontrib>Banas, Bernhard</creatorcontrib><creatorcontrib>Smith, Blair H</creatorcontrib><creatorcontrib>Spracklen, Cassandra N</creatorcontrib><creatorcontrib>Fuchsberger, Christian</creatorcontrib><creatorcontrib>Shaffer, Christian M</creatorcontrib><creatorcontrib>Gudbjartsson, Daniel F</creatorcontrib><creatorcontrib>Czamara, Darina</creatorcontrib><creatorcontrib>Porteous, David J</creatorcontrib><creatorcontrib>Waterworth, Dawn M</creatorcontrib><creatorcontrib>Mascalzoni, Deborah</creatorcontrib><creatorcontrib>Reilly, Dermot F</creatorcontrib><creatorcontrib>Salvi, Erika</creatorcontrib><creatorcontrib>Guo, Feng</creatorcontrib><creatorcontrib>Sveinbjornsson, Gardar</creatorcontrib><creatorcontrib>Ehret, Georg</creatorcontrib><creatorcontrib>Nadkarni, Girish N</creatorcontrib><creatorcontrib>Snieder, Harold</creatorcontrib><creatorcontrib>Campbell, Harry</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><creatorcontrib>Kramer, Holly</creatorcontrib><creatorcontrib>Halbritter, Jan</creatorcontrib><creatorcontrib>Rotter, Jerome I</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Ärnlöv, Johan</creatorcontrib><creatorcontrib>Tremblay, Johanne</creatorcontrib><creatorcontrib>Whitfield, John B</creatorcontrib><creatorcontrib>Gaziano, John M</creatorcontrib><creatorcontrib>Coresh, Josef</creatorcontrib><creatorcontrib>Eckardt, Kai-Uwe</creatorcontrib><creatorcontrib>Ryan, Kathleen A</creatorcontrib><creatorcontrib>Taylor, Kent D</creatorcontrib><creatorcontrib>Nikus, Kjell</creatorcontrib><creatorcontrib>Matsuda, Koichi</creatorcontrib><creatorcontrib>Wallentin, Lars</creatorcontrib><creatorcontrib>Phillips, Lawrence S</creatorcontrib><creatorcontrib>Klaric, Lucija</creatorcontrib><creatorcontrib>Kleber, Marcus E</creatorcontrib><creatorcontrib>Orho-Melander, Marju</creatorcontrib><creatorcontrib>Laakso, Markku</creatorcontrib><creatorcontrib>de Borst, Martin H</creatorcontrib><creatorcontrib>Lukas, Mary Ann</creatorcontrib><creatorcontrib>Wojczynski, Mary K</creatorcontrib><creatorcontrib>Kavousi, Maryam</creatorcontrib><creatorcontrib>Akiyama, Masato</creatorcontrib><creatorcontrib>Yasuda, Masayuki</creatorcontrib><creatorcontrib>Chee, Miao-Li</creatorcontrib><creatorcontrib>Chee, Miao-Ling</creatorcontrib><creatorcontrib>Boehnke, Michael</creatorcontrib><creatorcontrib>Preuss, Michael H</creatorcontrib><creatorcontrib>Stumvoll, Michael</creatorcontrib><creatorcontrib>Evans, Michele K</creatorcontrib><creatorcontrib>Kastarinen, Mika</creatorcontrib><creatorcontrib>Nalls, Mike A</creatorcontrib><creatorcontrib>Hutri-Kähönen, Nina</creatorcontrib><creatorcontrib>Raitakari, Olli T</creatorcontrib><creatorcontrib>Sulem, Patrick</creatorcontrib><creatorcontrib>Magnusson, Patrik K. E</creatorcontrib><creatorcontrib>Rossing, Peter</creatorcontrib><creatorcontrib>Vollenweider, Peter</creatorcontrib><creatorcontrib>Carroll, Robert J</creatorcontrib><creatorcontrib>Felicita, Sala Cinzia</creatorcontrib><creatorcontrib>Sedaghat, Sanaz</creatorcontrib><creatorcontrib>Padmanabhan, Sandosh</creatorcontrib><creatorcontrib>Pendergrass, Sarah A</creatorcontrib><creatorcontrib>Graham, Sarah E</creatorcontrib><creatorcontrib>Vaccargiu, Simona</creatorcontrib><creatorcontrib>Lim, Su-Chi</creatorcontrib><creatorcontrib>Vogelezang, Suzanne</creatorcontrib><creatorcontrib>Corre, Tanguy</creatorcontrib><creatorcontrib>Ahluwalia, Tarunveer S</creatorcontrib><creatorcontrib>Boutin, Thibaud S</creatorcontrib><creatorcontrib>Meitinger, Thomas</creatorcontrib><creatorcontrib>Völker, Uwe</creatorcontrib><creatorcontrib>Salomaa, Veikko</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V</creatorcontrib><creatorcontrib>Wei, Wen Bin</creatorcontrib><creatorcontrib>Kiess, Wieland</creatorcontrib><creatorcontrib>März, Winfried</creatorcontrib><creatorcontrib>Sim, Xueling</creatorcontrib><creatorcontrib>Okada, Yukinori</creatorcontrib><creatorcontrib>Milaneschi, Yuri</creatorcontrib><creatorcontrib>Yu, Zhi</creatorcontrib><creatorcontrib>Stark, Klaus J</creatorcontrib><creatorcontrib>Köttgen, Anna</creatorcontrib><collection>NORA - Norwegian Open Research Archives</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Cusi, Daniele</au><au>Li, Man</au><au>Scholz, Markus</au><au>van der Most, Peter J</au><au>Yang, Qiong</au><au>Nutile, Teresa</au><au>Günther, Felix</au><au>De Grandi, Alessandro</au><au>Franke, Andre</au><au>Metspalu, Andres</au><au>Hicks, Andrew A</au><au>Tönjes, Anke</au><au>Podgornaia, Anna I</au><au>Spedicati, Beatrice</au><au>Ponte, Belen</au><au>Schöttker, Ben</au><au>Banas, Bernhard</au><au>Smith, Blair H</au><au>Spracklen, Cassandra N</au><au>Fuchsberger, Christian</au><au>Shaffer, Christian M</au><au>Gudbjartsson, Daniel F</au><au>Czamara, Darina</au><au>Porteous, David J</au><au>Waterworth, Dawn M</au><au>Mascalzoni, Deborah</au><au>Reilly, Dermot F</au><au>Salvi, Erika</au><au>Guo, Feng</au><au>Sveinbjornsson, Gardar</au><au>Ehret, Georg</au><au>Nadkarni, Girish N</au><au>Snieder, Harold</au><au>Campbell, Harry</au><au>Brenner, Hermann</au><au>Kramer, Holly</au><au>Halbritter, Jan</au><au>Rotter, Jerome I</au><au>Thiery, Joachim</au><au>Ärnlöv, Johan</au><au>Tremblay, Johanne</au><au>Whitfield, John B</au><au>Gaziano, John M</au><au>Coresh, Josef</au><au>Eckardt, Kai-Uwe</au><au>Ryan, Kathleen A</au><au>Taylor, Kent D</au><au>Nikus, Kjell</au><au>Matsuda, Koichi</au><au>Wallentin, Lars</au><au>Phillips, Lawrence S</au><au>Klaric, Lucija</au><au>Kleber, Marcus E</au><au>Orho-Melander, Marju</au><au>Laakso, Markku</au><au>de Borst, Martin H</au><au>Lukas, Mary Ann</au><au>Wojczynski, Mary K</au><au>Kavousi, Maryam</au><au>Akiyama, Masato</au><au>Yasuda, Masayuki</au><au>Chee, Miao-Li</au><au>Chee, Miao-Ling</au><au>Boehnke, Michael</au><au>Preuss, Michael H</au><au>Stumvoll, Michael</au><au>Evans, Michele K</au><au>Kastarinen, Mika</au><au>Nalls, Mike A</au><au>Hutri-Kähönen, Nina</au><au>Raitakari, Olli T</au><au>Sulem, Patrick</au><au>Magnusson, Patrik K. E</au><au>Rossing, Peter</au><au>Vollenweider, Peter</au><au>Carroll, Robert J</au><au>Felicita, Sala Cinzia</au><au>Sedaghat, Sanaz</au><au>Padmanabhan, Sandosh</au><au>Pendergrass, Sarah A</au><au>Graham, Sarah E</au><au>Vaccargiu, Simona</au><au>Lim, Su-Chi</au><au>Vogelezang, Suzanne</au><au>Corre, Tanguy</au><au>Ahluwalia, Tarunveer S</au><au>Boutin, Thibaud S</au><au>Meitinger, Thomas</au><au>Völker, Uwe</au><au>Salomaa, Veikko</au><au>Jaddoe, Vincent W. V</au><au>Wei, Wen Bin</au><au>Kiess, Wieland</au><au>März, Winfried</au><au>Sim, Xueling</au><au>Okada, Yukinori</au><au>Milaneschi, Yuri</au><au>Yu, Zhi</au><au>Stark, Klaus J</au><au>Köttgen, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals</atitle><date>2022</date><risdate>2022</risdate><abstract>Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.</abstract><pub>Nature</pub><oa>free_for_read</oa></addata></record> |
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| title | Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals |
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