Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)

Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)

Background The burden of non-obstructive coronary artery disease (CAD) in the society is high, and there is currently limited evidence-based recommendation for risk stratification and treatment. Previous studies have demonstrated an association between increasing extent of non-obstructive CAD and ca...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Berge, Caroline A, Eskerud, Ingeborg, Almeland, Elise Botnevik, Larsen, Terje Hjalmar, Pedersen, Eva Ringdal, Rotevatn, Svein, Lønnebakken, Mai Tone
Format: Artikel
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Berge, Caroline A
Eskerud, Ingeborg
Almeland, Elise Botnevik
Larsen, Terje Hjalmar
Pedersen, Eva Ringdal
Rotevatn, Svein
Lønnebakken, Mai Tone
description Background The burden of non-obstructive coronary artery disease (CAD) in the society is high, and there is currently limited evidence-based recommendation for risk stratification and treatment. Previous studies have demonstrated an association between increasing extent of non-obstructive CAD and cardiovascular events. Whether hypertension, a modifiable cardiovascular risk factor, is associated with extensive non-obstructive CAD in patients with symptomatic chronic coronary syndrome (CCS) remains unclear. Methods We included 1138 patients (mean age 62±11 years, 48% women) with symptomatic CCS and non-obstructive CAD (1–49% lumen diameter reduction) by coronary computed tomography angiography (CCTA) from the Norwegian Registry for Invasive Cardiology (NORIC). The extent of non-obstructive CAD was assessed as coronary artery segment involvement score (SIS), and extensive non-obstructive CAD was adjudicated when SIS >4. Hypertension was defined as known hypertension or use of antihypertensive medication. Results Hypertension was found in 45% of patients. Hypertensive patients were older, with a higher SIS, calcium score, and prevalence of comorbidities and statin therapy compared to the normotensive (all p
format Article
fullrecord <record><control><sourceid>cristin_3HK</sourceid><recordid>TN_cdi_cristin_nora_11250_2997609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11250_2997609</sourcerecordid><originalsourceid>FETCH-cristin_nora_11250_29976093</originalsourceid><addsrcrecordid>eNqNzDELwjAQhuEuDqL-h3PTQWgrVToXRReF4l7S9DQH9VIuUcnibzeD4Or0Dt_DN07eNfbKk2VnaIAW_QuRwYQBxSO7OIDiDtiybZ2Xh_b0RNBWLCsJoKKK6cihcgjEoE2cSP-IC9yJvSMsvEE4netjBYI3im9hOU1GV9U7nH07Seb73aU6rLREQNywFdVkWV6kTV6W201arv8xH1zWSSQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)</title><source>NORA - Norwegian Open Research Archives</source><creator>Berge, Caroline A ; Eskerud, Ingeborg ; Almeland, Elise Botnevik ; Larsen, Terje Hjalmar ; Pedersen, Eva Ringdal ; Rotevatn, Svein ; Lønnebakken, Mai Tone</creator><creatorcontrib>Berge, Caroline A ; Eskerud, Ingeborg ; Almeland, Elise Botnevik ; Larsen, Terje Hjalmar ; Pedersen, Eva Ringdal ; Rotevatn, Svein ; Lønnebakken, Mai Tone</creatorcontrib><description>Background The burden of non-obstructive coronary artery disease (CAD) in the society is high, and there is currently limited evidence-based recommendation for risk stratification and treatment. Previous studies have demonstrated an association between increasing extent of non-obstructive CAD and cardiovascular events. Whether hypertension, a modifiable cardiovascular risk factor, is associated with extensive non-obstructive CAD in patients with symptomatic chronic coronary syndrome (CCS) remains unclear. Methods We included 1138 patients (mean age 62±11 years, 48% women) with symptomatic CCS and non-obstructive CAD (1–49% lumen diameter reduction) by coronary computed tomography angiography (CCTA) from the Norwegian Registry for Invasive Cardiology (NORIC). The extent of non-obstructive CAD was assessed as coronary artery segment involvement score (SIS), and extensive non-obstructive CAD was adjudicated when SIS &gt;4. Hypertension was defined as known hypertension or use of antihypertensive medication. Results Hypertension was found in 45% of patients. Hypertensive patients were older, with a higher SIS, calcium score, and prevalence of comorbidities and statin therapy compared to the normotensive (all p&lt;0.05). There was no difference in the prevalence of hypertension between sexes. Univariable analysis revealed a significant association between hypertension and non-obstructive CAD. In multivariable analysis, hypertension remained associated with extensive non-obstructive CAD, independent of sex, age, smoking, diabetes, statin treatment, obesity and calcium score (OR 1.85, 95% CI [1.22–2.80], p = 0.004). Conclusion In symptomatic CCS, hypertension was associated with extensive non-obstructive CAD by CCTA. Whether hypertension may be a new treatment target in symptomatic non-obstructive CAD needs to be explored in future studies.</description><language>eng</language><publisher>PLOS</publisher><creationdate>2022</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,26567</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/11250/2997609$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Berge, Caroline A</creatorcontrib><creatorcontrib>Eskerud, Ingeborg</creatorcontrib><creatorcontrib>Almeland, Elise Botnevik</creatorcontrib><creatorcontrib>Larsen, Terje Hjalmar</creatorcontrib><creatorcontrib>Pedersen, Eva Ringdal</creatorcontrib><creatorcontrib>Rotevatn, Svein</creatorcontrib><creatorcontrib>Lønnebakken, Mai Tone</creatorcontrib><title>Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)</title><description>Background The burden of non-obstructive coronary artery disease (CAD) in the society is high, and there is currently limited evidence-based recommendation for risk stratification and treatment. Previous studies have demonstrated an association between increasing extent of non-obstructive CAD and cardiovascular events. Whether hypertension, a modifiable cardiovascular risk factor, is associated with extensive non-obstructive CAD in patients with symptomatic chronic coronary syndrome (CCS) remains unclear. Methods We included 1138 patients (mean age 62±11 years, 48% women) with symptomatic CCS and non-obstructive CAD (1–49% lumen diameter reduction) by coronary computed tomography angiography (CCTA) from the Norwegian Registry for Invasive Cardiology (NORIC). The extent of non-obstructive CAD was assessed as coronary artery segment involvement score (SIS), and extensive non-obstructive CAD was adjudicated when SIS &gt;4. Hypertension was defined as known hypertension or use of antihypertensive medication. Results Hypertension was found in 45% of patients. Hypertensive patients were older, with a higher SIS, calcium score, and prevalence of comorbidities and statin therapy compared to the normotensive (all p&lt;0.05). There was no difference in the prevalence of hypertension between sexes. Univariable analysis revealed a significant association between hypertension and non-obstructive CAD. In multivariable analysis, hypertension remained associated with extensive non-obstructive CAD, independent of sex, age, smoking, diabetes, statin treatment, obesity and calcium score (OR 1.85, 95% CI [1.22–2.80], p = 0.004). Conclusion In symptomatic CCS, hypertension was associated with extensive non-obstructive CAD by CCTA. Whether hypertension may be a new treatment target in symptomatic non-obstructive CAD needs to be explored in future studies.</description><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNzDELwjAQhuEuDqL-h3PTQWgrVToXRReF4l7S9DQH9VIuUcnibzeD4Or0Dt_DN07eNfbKk2VnaIAW_QuRwYQBxSO7OIDiDtiybZ2Xh_b0RNBWLCsJoKKK6cihcgjEoE2cSP-IC9yJvSMsvEE4netjBYI3im9hOU1GV9U7nH07Seb73aU6rLREQNywFdVkWV6kTV6W201arv8xH1zWSSQ</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Berge, Caroline A</creator><creator>Eskerud, Ingeborg</creator><creator>Almeland, Elise Botnevik</creator><creator>Larsen, Terje Hjalmar</creator><creator>Pedersen, Eva Ringdal</creator><creator>Rotevatn, Svein</creator><creator>Lønnebakken, Mai Tone</creator><general>PLOS</general><scope>3HK</scope></search><sort><creationdate>2022</creationdate><title>Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)</title><author>Berge, Caroline A ; Eskerud, Ingeborg ; Almeland, Elise Botnevik ; Larsen, Terje Hjalmar ; Pedersen, Eva Ringdal ; Rotevatn, Svein ; Lønnebakken, Mai Tone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-cristin_nora_11250_29976093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Berge, Caroline A</creatorcontrib><creatorcontrib>Eskerud, Ingeborg</creatorcontrib><creatorcontrib>Almeland, Elise Botnevik</creatorcontrib><creatorcontrib>Larsen, Terje Hjalmar</creatorcontrib><creatorcontrib>Pedersen, Eva Ringdal</creatorcontrib><creatorcontrib>Rotevatn, Svein</creatorcontrib><creatorcontrib>Lønnebakken, Mai Tone</creatorcontrib><collection>NORA - Norwegian Open Research Archives</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Berge, Caroline A</au><au>Eskerud, Ingeborg</au><au>Almeland, Elise Botnevik</au><au>Larsen, Terje Hjalmar</au><au>Pedersen, Eva Ringdal</au><au>Rotevatn, Svein</au><au>Lønnebakken, Mai Tone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)</atitle><date>2022</date><risdate>2022</risdate><abstract>Background The burden of non-obstructive coronary artery disease (CAD) in the society is high, and there is currently limited evidence-based recommendation for risk stratification and treatment. Previous studies have demonstrated an association between increasing extent of non-obstructive CAD and cardiovascular events. Whether hypertension, a modifiable cardiovascular risk factor, is associated with extensive non-obstructive CAD in patients with symptomatic chronic coronary syndrome (CCS) remains unclear. Methods We included 1138 patients (mean age 62±11 years, 48% women) with symptomatic CCS and non-obstructive CAD (1–49% lumen diameter reduction) by coronary computed tomography angiography (CCTA) from the Norwegian Registry for Invasive Cardiology (NORIC). The extent of non-obstructive CAD was assessed as coronary artery segment involvement score (SIS), and extensive non-obstructive CAD was adjudicated when SIS &gt;4. Hypertension was defined as known hypertension or use of antihypertensive medication. Results Hypertension was found in 45% of patients. Hypertensive patients were older, with a higher SIS, calcium score, and prevalence of comorbidities and statin therapy compared to the normotensive (all p&lt;0.05). There was no difference in the prevalence of hypertension between sexes. Univariable analysis revealed a significant association between hypertension and non-obstructive CAD. In multivariable analysis, hypertension remained associated with extensive non-obstructive CAD, independent of sex, age, smoking, diabetes, statin treatment, obesity and calcium score (OR 1.85, 95% CI [1.22–2.80], p = 0.004). Conclusion In symptomatic CCS, hypertension was associated with extensive non-obstructive CAD by CCTA. Whether hypertension may be a new treatment target in symptomatic non-obstructive CAD needs to be explored in future studies.</abstract><pub>PLOS</pub><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_cristin_nora_11250_2997609
source NORA - Norwegian Open Research Archives
title Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T22%3A06%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-cristin_3HK&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20hypertension%20and%20nonobstructive%20coronary%20artery%20disease%20in%20chronic%20coronary%20syndrome%20(the%20NORIC%20registry)&rft.au=Berge,%20Caroline%20A&rft.date=2022&rft_id=info:doi/&rft_dat=%3Ccristin_3HK%3E11250_2997609%3C/cristin_3HK%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true