Effectiveness of collaborative care in reducing suicidal ideation: An individual participant data meta-analysis
Objective To assess whether CC is more effective at reducing suicidal ideation in people with depression compared with usual care, and whether study and patient factors moderate treatment effects. Method We searched Medline, Embase, PubMed, PsycINFO, CINAHL, CENTRAL from inception to March 2020 for...
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| creator | Grigoroglou, Christos van der Feltz-Cornelis, Christina Hodkinson, Alexander Coventry, Peter A Zghebi, Salwa S Kontopantelis, Evangelos Bower, Peter Lovell, Karina Gilbody, Simon Waheed, Waquas Dickens, Christopher Archer, Janine Blakemore, Amy Adler, David A Aragones, Enric Björkelund, Cecilia Bruce, Martha L Buszewicz, Marta Carney, Robert M Cole, Martin G Davidson, Karina W Gensichen, Jochen Grote, Nancy K Russo, Joan Huijbregts, Klaas Huffman, Jeff C Menchetti, Marco Patel, Vikram Richards, David A Rollman, Bruce Smit, Annet Zijlstra-Vlasveld, Moniek C Wells, Kenneth B Zimmermann, Thomas Unutzer, Jurgen Panagioti, Maria |
| description | Objective
To assess whether CC is more effective at reducing suicidal ideation in people with depression compared with usual care, and whether study and patient factors moderate treatment effects.
Method
We searched Medline, Embase, PubMed, PsycINFO, CINAHL, CENTRAL from inception to March 2020 for Randomised Controlled Trials (RCTs) that compared the effectiveness of CC with usual care in depressed adults, and reported changes in suicidal ideation at 4 to 6 months post-randomisation. Mixed-effects models accounted for clustering of participants within trials and heterogeneity across trials. This study is registered with PROSPERO, CRD42020201747.
Results
We extracted data from 28 RCTs (11,165 patients) of 83 eligible studies. We observed a small significant clinical improvement of CC on suicidal ideation, compared with usual care (SMD, −0.11 [95%CI, −0.15 to −0.08]; I2, 0·47% [95%CI 0.04% to 4.90%]). CC interventions with a recognised psychological treatment were associated with small reductions in suicidal ideation (SMD, −0.15 [95%CI -0.19 to −0.11]). CC was more effective for reducing suicidal ideation among patients aged over 65 years (SMD, − 0.18 [95%CI -0.25 to −0.11]).
Conclusion
Primary care based CC with an embedded psychological intervention is the most effective CC framework for reducing suicidal ideation and older patients may benefit the most. |
| format | Article |
| fullrecord | <record><control><sourceid>cristin_3HK</sourceid><recordid>TN_cdi_cristin_nora_11250_2982600</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11250_2982600</sourcerecordid><originalsourceid>FETCH-cristin_nora_11250_29826003</originalsourceid><addsrcrecordid>eNqNzUEKwjAQheFuXIh6h_EAhbSiqDuRigdwX8ZkUgbipGTSgrc3ggdw9eDng7esYuc92cwzCalC9GBjCPiMCb8RLCYCFkjkJssygE5s2WEAdlRIlDNcpAjHM7up9BFTLmREyeAwI7woY42C4a2s62rhMShtfruqtrfucb3XNrFmll7Kc9807d707enYHozZ_WM-KYFC3w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effectiveness of collaborative care in reducing suicidal ideation: An individual participant data meta-analysis</title><source>NORA - Norwegian Open Research Archives</source><creator>Grigoroglou, Christos ; van der Feltz-Cornelis, Christina ; Hodkinson, Alexander ; Coventry, Peter A ; Zghebi, Salwa S ; Kontopantelis, Evangelos ; Bower, Peter ; Lovell, Karina ; Gilbody, Simon ; Waheed, Waquas ; Dickens, Christopher ; Archer, Janine ; Blakemore, Amy ; Adler, David A ; Aragones, Enric ; Björkelund, Cecilia ; Bruce, Martha L ; Buszewicz, Marta ; Carney, Robert M ; Cole, Martin G ; Davidson, Karina W ; Gensichen, Jochen ; Grote, Nancy K ; Russo, Joan ; Huijbregts, Klaas ; Huffman, Jeff C ; Menchetti, Marco ; Patel, Vikram ; Richards, David A ; Rollman, Bruce ; Smit, Annet ; Zijlstra-Vlasveld, Moniek C ; Wells, Kenneth B ; Zimmermann, Thomas ; Unutzer, Jurgen ; Panagioti, Maria</creator><creatorcontrib>Grigoroglou, Christos ; van der Feltz-Cornelis, Christina ; Hodkinson, Alexander ; Coventry, Peter A ; Zghebi, Salwa S ; Kontopantelis, Evangelos ; Bower, Peter ; Lovell, Karina ; Gilbody, Simon ; Waheed, Waquas ; Dickens, Christopher ; Archer, Janine ; Blakemore, Amy ; Adler, David A ; Aragones, Enric ; Björkelund, Cecilia ; Bruce, Martha L ; Buszewicz, Marta ; Carney, Robert M ; Cole, Martin G ; Davidson, Karina W ; Gensichen, Jochen ; Grote, Nancy K ; Russo, Joan ; Huijbregts, Klaas ; Huffman, Jeff C ; Menchetti, Marco ; Patel, Vikram ; Richards, David A ; Rollman, Bruce ; Smit, Annet ; Zijlstra-Vlasveld, Moniek C ; Wells, Kenneth B ; Zimmermann, Thomas ; Unutzer, Jurgen ; Panagioti, Maria</creatorcontrib><description>Objective
To assess whether CC is more effective at reducing suicidal ideation in people with depression compared with usual care, and whether study and patient factors moderate treatment effects.
Method
We searched Medline, Embase, PubMed, PsycINFO, CINAHL, CENTRAL from inception to March 2020 for Randomised Controlled Trials (RCTs) that compared the effectiveness of CC with usual care in depressed adults, and reported changes in suicidal ideation at 4 to 6 months post-randomisation. Mixed-effects models accounted for clustering of participants within trials and heterogeneity across trials. This study is registered with PROSPERO, CRD42020201747.
Results
We extracted data from 28 RCTs (11,165 patients) of 83 eligible studies. We observed a small significant clinical improvement of CC on suicidal ideation, compared with usual care (SMD, −0.11 [95%CI, −0.15 to −0.08]; I2, 0·47% [95%CI 0.04% to 4.90%]). CC interventions with a recognised psychological treatment were associated with small reductions in suicidal ideation (SMD, −0.15 [95%CI -0.19 to −0.11]). CC was more effective for reducing suicidal ideation among patients aged over 65 years (SMD, − 0.18 [95%CI -0.25 to −0.11]).
Conclusion
Primary care based CC with an embedded psychological intervention is the most effective CC framework for reducing suicidal ideation and older patients may benefit the most.</description><language>eng</language><publisher>Elsevier</publisher><creationdate>2021</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,26546</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/11250/2982600$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Grigoroglou, Christos</creatorcontrib><creatorcontrib>van der Feltz-Cornelis, Christina</creatorcontrib><creatorcontrib>Hodkinson, Alexander</creatorcontrib><creatorcontrib>Coventry, Peter A</creatorcontrib><creatorcontrib>Zghebi, Salwa S</creatorcontrib><creatorcontrib>Kontopantelis, Evangelos</creatorcontrib><creatorcontrib>Bower, Peter</creatorcontrib><creatorcontrib>Lovell, Karina</creatorcontrib><creatorcontrib>Gilbody, Simon</creatorcontrib><creatorcontrib>Waheed, Waquas</creatorcontrib><creatorcontrib>Dickens, Christopher</creatorcontrib><creatorcontrib>Archer, Janine</creatorcontrib><creatorcontrib>Blakemore, Amy</creatorcontrib><creatorcontrib>Adler, David A</creatorcontrib><creatorcontrib>Aragones, Enric</creatorcontrib><creatorcontrib>Björkelund, Cecilia</creatorcontrib><creatorcontrib>Bruce, Martha L</creatorcontrib><creatorcontrib>Buszewicz, Marta</creatorcontrib><creatorcontrib>Carney, Robert M</creatorcontrib><creatorcontrib>Cole, Martin G</creatorcontrib><creatorcontrib>Davidson, Karina W</creatorcontrib><creatorcontrib>Gensichen, Jochen</creatorcontrib><creatorcontrib>Grote, Nancy K</creatorcontrib><creatorcontrib>Russo, Joan</creatorcontrib><creatorcontrib>Huijbregts, Klaas</creatorcontrib><creatorcontrib>Huffman, Jeff C</creatorcontrib><creatorcontrib>Menchetti, Marco</creatorcontrib><creatorcontrib>Patel, Vikram</creatorcontrib><creatorcontrib>Richards, David A</creatorcontrib><creatorcontrib>Rollman, Bruce</creatorcontrib><creatorcontrib>Smit, Annet</creatorcontrib><creatorcontrib>Zijlstra-Vlasveld, Moniek C</creatorcontrib><creatorcontrib>Wells, Kenneth B</creatorcontrib><creatorcontrib>Zimmermann, Thomas</creatorcontrib><creatorcontrib>Unutzer, Jurgen</creatorcontrib><creatorcontrib>Panagioti, Maria</creatorcontrib><title>Effectiveness of collaborative care in reducing suicidal ideation: An individual participant data meta-analysis</title><description>Objective
To assess whether CC is more effective at reducing suicidal ideation in people with depression compared with usual care, and whether study and patient factors moderate treatment effects.
Method
We searched Medline, Embase, PubMed, PsycINFO, CINAHL, CENTRAL from inception to March 2020 for Randomised Controlled Trials (RCTs) that compared the effectiveness of CC with usual care in depressed adults, and reported changes in suicidal ideation at 4 to 6 months post-randomisation. Mixed-effects models accounted for clustering of participants within trials and heterogeneity across trials. This study is registered with PROSPERO, CRD42020201747.
Results
We extracted data from 28 RCTs (11,165 patients) of 83 eligible studies. We observed a small significant clinical improvement of CC on suicidal ideation, compared with usual care (SMD, −0.11 [95%CI, −0.15 to −0.08]; I2, 0·47% [95%CI 0.04% to 4.90%]). CC interventions with a recognised psychological treatment were associated with small reductions in suicidal ideation (SMD, −0.15 [95%CI -0.19 to −0.11]). CC was more effective for reducing suicidal ideation among patients aged over 65 years (SMD, − 0.18 [95%CI -0.25 to −0.11]).
Conclusion
Primary care based CC with an embedded psychological intervention is the most effective CC framework for reducing suicidal ideation and older patients may benefit the most.</description><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNzUEKwjAQheFuXIh6h_EAhbSiqDuRigdwX8ZkUgbipGTSgrc3ggdw9eDng7esYuc92cwzCalC9GBjCPiMCb8RLCYCFkjkJssygE5s2WEAdlRIlDNcpAjHM7up9BFTLmREyeAwI7woY42C4a2s62rhMShtfruqtrfucb3XNrFmll7Kc9807d707enYHozZ_WM-KYFC3w</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Grigoroglou, Christos</creator><creator>van der Feltz-Cornelis, Christina</creator><creator>Hodkinson, Alexander</creator><creator>Coventry, Peter A</creator><creator>Zghebi, Salwa S</creator><creator>Kontopantelis, Evangelos</creator><creator>Bower, Peter</creator><creator>Lovell, Karina</creator><creator>Gilbody, Simon</creator><creator>Waheed, Waquas</creator><creator>Dickens, Christopher</creator><creator>Archer, Janine</creator><creator>Blakemore, Amy</creator><creator>Adler, David A</creator><creator>Aragones, Enric</creator><creator>Björkelund, Cecilia</creator><creator>Bruce, Martha L</creator><creator>Buszewicz, Marta</creator><creator>Carney, Robert M</creator><creator>Cole, Martin G</creator><creator>Davidson, Karina W</creator><creator>Gensichen, Jochen</creator><creator>Grote, Nancy K</creator><creator>Russo, Joan</creator><creator>Huijbregts, Klaas</creator><creator>Huffman, Jeff C</creator><creator>Menchetti, Marco</creator><creator>Patel, Vikram</creator><creator>Richards, David A</creator><creator>Rollman, Bruce</creator><creator>Smit, Annet</creator><creator>Zijlstra-Vlasveld, Moniek C</creator><creator>Wells, Kenneth B</creator><creator>Zimmermann, Thomas</creator><creator>Unutzer, Jurgen</creator><creator>Panagioti, Maria</creator><general>Elsevier</general><scope>3HK</scope></search><sort><creationdate>2021</creationdate><title>Effectiveness of collaborative care in reducing suicidal ideation: An individual participant data meta-analysis</title><author>Grigoroglou, Christos ; van der Feltz-Cornelis, Christina ; Hodkinson, Alexander ; Coventry, Peter A ; Zghebi, Salwa S ; Kontopantelis, Evangelos ; Bower, Peter ; Lovell, Karina ; Gilbody, Simon ; Waheed, Waquas ; Dickens, Christopher ; Archer, Janine ; Blakemore, Amy ; Adler, David A ; Aragones, Enric ; Björkelund, Cecilia ; Bruce, Martha L ; Buszewicz, Marta ; Carney, Robert M ; Cole, Martin G ; Davidson, Karina W ; Gensichen, Jochen ; Grote, Nancy K ; Russo, Joan ; Huijbregts, Klaas ; Huffman, Jeff C ; Menchetti, Marco ; Patel, Vikram ; Richards, David A ; Rollman, Bruce ; Smit, Annet ; Zijlstra-Vlasveld, Moniek C ; Wells, Kenneth B ; Zimmermann, Thomas ; Unutzer, Jurgen ; Panagioti, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-cristin_nora_11250_29826003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Grigoroglou, Christos</creatorcontrib><creatorcontrib>van der Feltz-Cornelis, Christina</creatorcontrib><creatorcontrib>Hodkinson, Alexander</creatorcontrib><creatorcontrib>Coventry, Peter A</creatorcontrib><creatorcontrib>Zghebi, Salwa S</creatorcontrib><creatorcontrib>Kontopantelis, Evangelos</creatorcontrib><creatorcontrib>Bower, Peter</creatorcontrib><creatorcontrib>Lovell, Karina</creatorcontrib><creatorcontrib>Gilbody, Simon</creatorcontrib><creatorcontrib>Waheed, Waquas</creatorcontrib><creatorcontrib>Dickens, Christopher</creatorcontrib><creatorcontrib>Archer, Janine</creatorcontrib><creatorcontrib>Blakemore, Amy</creatorcontrib><creatorcontrib>Adler, David A</creatorcontrib><creatorcontrib>Aragones, Enric</creatorcontrib><creatorcontrib>Björkelund, Cecilia</creatorcontrib><creatorcontrib>Bruce, Martha L</creatorcontrib><creatorcontrib>Buszewicz, Marta</creatorcontrib><creatorcontrib>Carney, Robert M</creatorcontrib><creatorcontrib>Cole, Martin G</creatorcontrib><creatorcontrib>Davidson, Karina W</creatorcontrib><creatorcontrib>Gensichen, Jochen</creatorcontrib><creatorcontrib>Grote, Nancy K</creatorcontrib><creatorcontrib>Russo, Joan</creatorcontrib><creatorcontrib>Huijbregts, Klaas</creatorcontrib><creatorcontrib>Huffman, Jeff C</creatorcontrib><creatorcontrib>Menchetti, Marco</creatorcontrib><creatorcontrib>Patel, Vikram</creatorcontrib><creatorcontrib>Richards, David A</creatorcontrib><creatorcontrib>Rollman, Bruce</creatorcontrib><creatorcontrib>Smit, Annet</creatorcontrib><creatorcontrib>Zijlstra-Vlasveld, Moniek C</creatorcontrib><creatorcontrib>Wells, Kenneth B</creatorcontrib><creatorcontrib>Zimmermann, Thomas</creatorcontrib><creatorcontrib>Unutzer, Jurgen</creatorcontrib><creatorcontrib>Panagioti, Maria</creatorcontrib><collection>NORA - Norwegian Open Research Archives</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Grigoroglou, Christos</au><au>van der Feltz-Cornelis, Christina</au><au>Hodkinson, Alexander</au><au>Coventry, Peter A</au><au>Zghebi, Salwa S</au><au>Kontopantelis, Evangelos</au><au>Bower, Peter</au><au>Lovell, Karina</au><au>Gilbody, Simon</au><au>Waheed, Waquas</au><au>Dickens, Christopher</au><au>Archer, Janine</au><au>Blakemore, Amy</au><au>Adler, David A</au><au>Aragones, Enric</au><au>Björkelund, Cecilia</au><au>Bruce, Martha L</au><au>Buszewicz, Marta</au><au>Carney, Robert M</au><au>Cole, Martin G</au><au>Davidson, Karina W</au><au>Gensichen, Jochen</au><au>Grote, Nancy K</au><au>Russo, Joan</au><au>Huijbregts, Klaas</au><au>Huffman, Jeff C</au><au>Menchetti, Marco</au><au>Patel, Vikram</au><au>Richards, David A</au><au>Rollman, Bruce</au><au>Smit, Annet</au><au>Zijlstra-Vlasveld, Moniek C</au><au>Wells, Kenneth B</au><au>Zimmermann, Thomas</au><au>Unutzer, Jurgen</au><au>Panagioti, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of collaborative care in reducing suicidal ideation: An individual participant data meta-analysis</atitle><date>2021</date><risdate>2021</risdate><abstract>Objective
To assess whether CC is more effective at reducing suicidal ideation in people with depression compared with usual care, and whether study and patient factors moderate treatment effects.
Method
We searched Medline, Embase, PubMed, PsycINFO, CINAHL, CENTRAL from inception to March 2020 for Randomised Controlled Trials (RCTs) that compared the effectiveness of CC with usual care in depressed adults, and reported changes in suicidal ideation at 4 to 6 months post-randomisation. Mixed-effects models accounted for clustering of participants within trials and heterogeneity across trials. This study is registered with PROSPERO, CRD42020201747.
Results
We extracted data from 28 RCTs (11,165 patients) of 83 eligible studies. We observed a small significant clinical improvement of CC on suicidal ideation, compared with usual care (SMD, −0.11 [95%CI, −0.15 to −0.08]; I2, 0·47% [95%CI 0.04% to 4.90%]). CC interventions with a recognised psychological treatment were associated with small reductions in suicidal ideation (SMD, −0.15 [95%CI -0.19 to −0.11]). CC was more effective for reducing suicidal ideation among patients aged over 65 years (SMD, − 0.18 [95%CI -0.25 to −0.11]).
Conclusion
Primary care based CC with an embedded psychological intervention is the most effective CC framework for reducing suicidal ideation and older patients may benefit the most.</abstract><pub>Elsevier</pub><oa>free_for_read</oa></addata></record> |
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| title | Effectiveness of collaborative care in reducing suicidal ideation: An individual participant data meta-analysis |
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