Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models

The development of immune checkpoint inhibitors represents a major breakthrough in cancer therapy. Nevertheless, a substantial number of patients fail to respond to checkpoint pathway blockade. Evidence for WNT/β-catenin signaling-mediated immune evasion is found in a subset of cancers including mel...

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Hauptverfasser:	Waaler, Jo, Mygland, Line, Tveita, Anders Aune, Strand, Martin Frank, Solberg, Nina, Olsen, Petter Angell, Aizenshtadt, Aleksandra, Fauskanger, Marte, Lund, Kaja, Brinch, Shoshy Alam, Lycke, Max, Dybing, Elisabeth, Nygaard, Vegard, Bøe, Sigurd, Heintz, Karen Marie, Hovig, Eivind, Hammarström, Clara Louise, Corthay, Alexandre, Krauss, Stefan
Format:	Artikel
Sprache:	eng
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