Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data
Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight
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| creator | Rogne, Tormod Tielemans, MJ Chong, MF Yajnik, CS Krishnaveni, GV Poston, Lucilla Jaddoe, VW Steegers, EA Joshi, S Chong, YS Godfrey, KM Yap, F Yahyaoui, R Thomas, T Hay, Gry Hogeveen, M Demir, Ahmet Saravanan, P Skovlund, Eva Martinussen, Marit Jacobsen, Geir Wenberg Franco, OH Bracken, Michael B Risnes, Kari |
| description | Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight |
| format | Article |
| fullrecord | <record><control><sourceid>cristin_3HK</sourceid><recordid>TN_cdi_cristin_nora_11250_2429099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11250_2429099</sourcerecordid><originalsourceid>FETCH-cristin_nora_11250_24290993</originalsourceid><addsrcrecordid>eNqNjk3KwkAMhrtxIeod4gEEWz8XdVf_UFAQFV2WMI02aDMyE5VezdM5FA_wrULyPjx529En894aRmUrHuwFtqjkBO9wYsWKBaZxAjMrhkRdg0E47hxdBcXUcGYtQUuCPftbYwhZUFQwZRcilAI29v3bzsTXUieQwaH2SlUQGtjTi-ndkFtSHGThfe25ka2l4BcXz1Bohy7Q_EBRmKNiN2pd8O6p95udqL9cHGergXHslSUX6zCP42Q8zJO_JB2m6eg_zBeLo1xP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data</title><source>NORA - Norwegian Open Research Archives</source><creator>Rogne, Tormod ; Tielemans, MJ ; Chong, MF ; Yajnik, CS ; Krishnaveni, GV ; Poston, Lucilla ; Jaddoe, VW ; Steegers, EA ; Joshi, S ; Chong, YS ; Godfrey, KM ; Yap, F ; Yahyaoui, R ; Thomas, T ; Hay, Gry ; Hogeveen, M ; Demir, Ahmet ; Saravanan, P ; Skovlund, Eva ; Martinussen, Marit ; Jacobsen, Geir Wenberg ; Franco, OH ; Bracken, Michael B ; Risnes, Kari</creator><creatorcontrib>Rogne, Tormod ; Tielemans, MJ ; Chong, MF ; Yajnik, CS ; Krishnaveni, GV ; Poston, Lucilla ; Jaddoe, VW ; Steegers, EA ; Joshi, S ; Chong, YS ; Godfrey, KM ; Yap, F ; Yahyaoui, R ; Thomas, T ; Hay, Gry ; Hogeveen, M ; Demir, Ahmet ; Saravanan, P ; Skovlund, Eva ; Martinussen, Marit ; Jacobsen, Geir Wenberg ; Franco, OH ; Bracken, Michael B ; Risnes, Kari</creatorcontrib><description>Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations). Eighteen studies were included in the meta-analysis (11,216 observations). No linear association was observed between maternal B12 levels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L) was associated with a higher risk of low birth weight in newborns (adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1.31). There was a linear association between maternal levels of B12 and preterm birth (per each 1-standard-deviation increase in B12, adjusted risk ratio = 0.89, 95% CI: 0.82, 0.97). Accordingly, B12 deficiency was associated with a higher risk of preterm birth (adjusted risk ratio = 1.21, 95% CI: 0.99, 1.49). This finding supports the need for randomized controlled trials of vitamin B12 supplementation in pregnancy.</description><language>eng</language><publisher>Oxford university press</publisher><subject>low birth weight, pregnancy, preterm birth, systematic review, vitamin B12</subject><creationdate>2017</creationdate><rights>info:eu-repo/semantics/openAccess</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,26567</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/11250/2429099$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Rogne, Tormod</creatorcontrib><creatorcontrib>Tielemans, MJ</creatorcontrib><creatorcontrib>Chong, MF</creatorcontrib><creatorcontrib>Yajnik, CS</creatorcontrib><creatorcontrib>Krishnaveni, GV</creatorcontrib><creatorcontrib>Poston, Lucilla</creatorcontrib><creatorcontrib>Jaddoe, VW</creatorcontrib><creatorcontrib>Steegers, EA</creatorcontrib><creatorcontrib>Joshi, S</creatorcontrib><creatorcontrib>Chong, YS</creatorcontrib><creatorcontrib>Godfrey, KM</creatorcontrib><creatorcontrib>Yap, F</creatorcontrib><creatorcontrib>Yahyaoui, R</creatorcontrib><creatorcontrib>Thomas, T</creatorcontrib><creatorcontrib>Hay, Gry</creatorcontrib><creatorcontrib>Hogeveen, M</creatorcontrib><creatorcontrib>Demir, Ahmet</creatorcontrib><creatorcontrib>Saravanan, P</creatorcontrib><creatorcontrib>Skovlund, Eva</creatorcontrib><creatorcontrib>Martinussen, Marit</creatorcontrib><creatorcontrib>Jacobsen, Geir Wenberg</creatorcontrib><creatorcontrib>Franco, OH</creatorcontrib><creatorcontrib>Bracken, Michael B</creatorcontrib><creatorcontrib>Risnes, Kari</creatorcontrib><title>Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data</title><description>Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations). Eighteen studies were included in the meta-analysis (11,216 observations). No linear association was observed between maternal B12 levels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L) was associated with a higher risk of low birth weight in newborns (adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1.31). There was a linear association between maternal levels of B12 and preterm birth (per each 1-standard-deviation increase in B12, adjusted risk ratio = 0.89, 95% CI: 0.82, 0.97). Accordingly, B12 deficiency was associated with a higher risk of preterm birth (adjusted risk ratio = 1.21, 95% CI: 0.99, 1.49). 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Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations). Eighteen studies were included in the meta-analysis (11,216 observations). No linear association was observed between maternal B12 levels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L) was associated with a higher risk of low birth weight in newborns (adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1.31). There was a linear association between maternal levels of B12 and preterm birth (per each 1-standard-deviation increase in B12, adjusted risk ratio = 0.89, 95% CI: 0.82, 0.97). Accordingly, B12 deficiency was associated with a higher risk of preterm birth (adjusted risk ratio = 1.21, 95% CI: 0.99, 1.49). This finding supports the need for randomized controlled trials of vitamin B12 supplementation in pregnancy.</abstract><pub>Oxford university press</pub><oa>free_for_read</oa></addata></record> |
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| subjects | low birth weight, pregnancy, preterm birth, systematic review, vitamin B12 |
| title | Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data |
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