Antigen bivalency of antigen-presenting cell-targeted vaccines increases B cell responses

Antibodies are important for vaccine efficacy. Targeting antigens to antigen-presenting cells (APCs) increases antibody levels. Here, we explore the role of antigen valency in MHC class II (MHCII)-targeted vaccines delivered as DNA. We design heterodimeric proteins that carry either two identical (b...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-05, Vol.39 (9), p.110901-110901, Article 110901
Hauptverfasser:	Hinke, Daniëla Maria, Andersen, Tor Kristian, Gopalakrishnan, Ramakrishna Prabhu, Skullerud, Lise Madelene, Werninghaus, Ina Charlotta, Grødeland, Gunnveig, Fossum, Even, Braathen, Ranveig, Bogen, Bjarne
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody responses antigen multivalency DC targeting DC-B cell synapse DNA vaccine heterodimer influenza myeloma T cell responses
Online-Zugang:	Volltext
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