Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is characterized by chronic inflammation and progressive fibrosis of the biliary tree. The bile acid receptor TGR5 (GPBAR1) is found on biliary epithelial cells (BECs), where it promotes secretion, proliferation and tight junction integrity. Thus, we speculated t...

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Veröffentlicht in:	Journal of hepatology 2021-09, Vol.75 (3), p.634-646
Hauptverfasser:	Reich, Maria, Spomer, Lina, Klindt, Caroline, Fuchs, Katharina, Stindt, Jan, Deutschmann, Kathleen, Höhne, Johanna, Liaskou, Evaggelia, Hov, Johannes R., Karlsen, Tom H., Beuers, Ulrich, Verheij, Joanne, Ferreira-Gonzalez, Sofia, Hirschfield, Gideon, Forbes, Stuart J., Schramm, Christoph, Esposito, Irene, Nierhoff, Dirk, Fickert, Peter, Fuchs, Claudia Daniela, Trauner, Michael, García-Beccaria, María, Gabernet, Gisela, Nahnsen, Sven, Mallm, Jan-Philipp, Vogel, Marina, Schoonjans, Kristina, Lautwein, Tobias, Köhrer, Karl, Häussinger, Dieter, Luedde, Tom, Heikenwalder, Mathias, Keitel, Verena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals bile acid receptor Bile ducts biliary damage biliary organoids Biliary Tract - drug effects Biliary Tract - metabolism Cell proliferation Cholangitis Cholangitis, Sclerosing - drug therapy Cholangitis, Sclerosing - genetics Cholangitis, Sclerosing - physiopathology Disease Models, Animal Down-Regulation - drug effects Down-Regulation - genetics Down-Regulation - physiology Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - physiology Fibrosis Gene expression Immunofluorescence Inflammation Intercellular adhesion molecule 1 Interleukin 8 Liver - drug effects Liver - pathology Liver diseases Localization Macrophages Mice norUDCA Pathogenesis Phenotypes Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - metabolism scRNA-seq Ursodeoxycholic acid Virulence Factors
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