A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease
In a phase 2 proof-of-concept trial, patients with celiac disease controlled on a gluten-free diet were assigned to one of three dose levels of ZED1227 (a selective transglutaminase 2 inhibitor) or placebo. Patients were challenged with 3 g of gluten daily for 6 weeks. Comparison of duodenal-biopsy...
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| Veröffentlicht in: | The New England journal of medicine 2021-07, Vol.385 (1), p.35-45 |
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| creator | Schuppan, Detlef Mäki, Markku Lundin, Knut E.A Isola, Jorma Friesing-Sosnik, Tina Taavela, Juha Popp, Alina Koskenpato, Jari Langhorst, Jost Hovde, Øistein Lähdeaho, Marja-Leena Fusco, Stefano Schumann, Michael Török, Helga P Kupcinskas, Juozas Zopf, Yurdagül Lohse, Ansgar W Scheinin, Mika Kull, Karin Biedermann, Luc Byrnes, Valerie Stallmach, Andreas Jahnsen, Jørgen Zeitz, Jonas Mohrbacher, Ralf Greinwald, Roland |
| description | In a phase 2 proof-of-concept trial, patients with celiac disease controlled on a gluten-free diet were assigned to one of three dose levels of ZED1227 (a selective transglutaminase 2 inhibitor) or placebo. Patients were challenged with 3 g of gluten daily for 6 weeks. Comparison of duodenal-biopsy samples between baseline and 6 weeks showed that ZED1227 attenuated gluten-induced mucosal damage. |
| doi_str_mv | 10.1056/NEJMoa2032441 |
| format | Article |
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Patients were challenged with 3 g of gluten daily for 6 weeks. Comparison of duodenal-biopsy samples between baseline and 6 weeks showed that ZED1227 attenuated gluten-induced mucosal damage.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2032441</identifier><language>eng</language><publisher>Boston: Massachusetts Medical Society</publisher><subject>Adverse events ; Allergy ; Atrophy ; Biopsy ; Celiac disease ; Diarrhea ; Diet ; Disease ; Dosage ; Drug dosages ; Endoscopy ; Epithelial cells ; Gastroenterology ; Gastroenterology General ; Glutamine ; Gluten ; Hyperplasia ; Immunology ; Immunology General ; Laboratories ; Lymphocytes ; Lymphocytes T ; Morphology ; Mucosa ; Nausea ; Nutrition ; Patients ; Peptides ; Placebos ; Quality of life ; Questionnaires ; Small intestine ; Transglutaminase 2 ; Villus ; Vomiting</subject><ispartof>The New England journal of medicine, 2021-07, Vol.385 (1), p.35-45</ispartof><rights>Copyright © 2021 Massachusetts Medical Society. All rights reserved.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-c9b3d4163fc6485d0efebabe8706c0e1acbf5598a9b69c58184ac8e557def7c23</citedby><cites>FETCH-LOGICAL-c435t-c9b3d4163fc6485d0efebabe8706c0e1acbf5598a9b69c58184ac8e557def7c23</cites><orcidid>0000-0001-6093-4567</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2032441$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2032441$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,26544,27901,27902,52357,54039</link.rule.ids></links><search><creatorcontrib>Schuppan, Detlef</creatorcontrib><creatorcontrib>Mäki, Markku</creatorcontrib><creatorcontrib>Lundin, Knut E.A</creatorcontrib><creatorcontrib>Isola, Jorma</creatorcontrib><creatorcontrib>Friesing-Sosnik, Tina</creatorcontrib><creatorcontrib>Taavela, Juha</creatorcontrib><creatorcontrib>Popp, Alina</creatorcontrib><creatorcontrib>Koskenpato, Jari</creatorcontrib><creatorcontrib>Langhorst, Jost</creatorcontrib><creatorcontrib>Hovde, Øistein</creatorcontrib><creatorcontrib>Lähdeaho, Marja-Leena</creatorcontrib><creatorcontrib>Fusco, Stefano</creatorcontrib><creatorcontrib>Schumann, Michael</creatorcontrib><creatorcontrib>Török, Helga P</creatorcontrib><creatorcontrib>Kupcinskas, Juozas</creatorcontrib><creatorcontrib>Zopf, Yurdagül</creatorcontrib><creatorcontrib>Lohse, Ansgar W</creatorcontrib><creatorcontrib>Scheinin, Mika</creatorcontrib><creatorcontrib>Kull, Karin</creatorcontrib><creatorcontrib>Biedermann, Luc</creatorcontrib><creatorcontrib>Byrnes, Valerie</creatorcontrib><creatorcontrib>Stallmach, Andreas</creatorcontrib><creatorcontrib>Jahnsen, Jørgen</creatorcontrib><creatorcontrib>Zeitz, Jonas</creatorcontrib><creatorcontrib>Mohrbacher, Ralf</creatorcontrib><creatorcontrib>Greinwald, Roland</creatorcontrib><title>A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease</title><title>The New England journal of medicine</title><description>In a phase 2 proof-of-concept trial, patients with celiac disease controlled on a gluten-free diet were assigned to one of three dose levels of ZED1227 (a selective transglutaminase 2 inhibitor) or placebo. 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Comparison of duodenal-biopsy samples between baseline and 6 weeks showed that ZED1227 attenuated gluten-induced mucosal damage.</description><subject>Adverse events</subject><subject>Allergy</subject><subject>Atrophy</subject><subject>Biopsy</subject><subject>Celiac disease</subject><subject>Diarrhea</subject><subject>Diet</subject><subject>Disease</subject><subject>Dosage</subject><subject>Drug dosages</subject><subject>Endoscopy</subject><subject>Epithelial cells</subject><subject>Gastroenterology</subject><subject>Gastroenterology General</subject><subject>Glutamine</subject><subject>Gluten</subject><subject>Hyperplasia</subject><subject>Immunology</subject><subject>Immunology General</subject><subject>Laboratories</subject><subject>Lymphocytes</subject><subject>Lymphocytes 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| ispartof | The New England journal of medicine, 2021-07, Vol.385 (1), p.35-45 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | NORA - Norwegian Open Research Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine Current |
| subjects | Adverse events Allergy Atrophy Biopsy Celiac disease Diarrhea Diet Disease Dosage Drug dosages Endoscopy Epithelial cells Gastroenterology Gastroenterology General Glutamine Gluten Hyperplasia Immunology Immunology General Laboratories Lymphocytes Lymphocytes T Morphology Mucosa Nausea Nutrition Patients Peptides Placebos Quality of life Questionnaires Small intestine Transglutaminase 2 Villus Vomiting |
| title | A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease |
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