Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer

While large GWAS analyses have not found convincing associations between MDM2 promoter SNP55 and gynaecological cancers, SNP55 is in linkage disequilibrium with two other functional SNPs in the same promoter, likely to obscure associations between single SNPs and cancer risk. Here, we assessed the i...

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Veröffentlicht in:	Biomarkers 2021-05, Vol.26 (4), p.302-308
Hauptverfasser:	Helwa, Reham, Gansmo, Liv B., Bjørnslett, Merete, Halle, Mari Kyllesø, Werner, Henrica M. J., Romundstad, Pål, Hveem, Kristian, Vatten, Lars, Dørum, Anne, Lønning, Per E., Knappskog, Stian
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Case-Control Studies Cohort Studies endometrial cancer Endometrial Neoplasms - diagnosis Endometrial Neoplasms - genetics Female Gene Frequency Genetic Predisposition to Disease - genetics Genome-Wide Association Study - methods Genotype Humans Linkage Disequilibrium MDM2 Middle Aged ovarian cancer Ovarian Neoplasms - diagnosis Ovarian Neoplasms - genetics polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic - genetics Proto-Oncogene Proteins c-mdm2 - genetics risk SNP
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