Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study

Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study

To prospectively investigate the long-term relationship between body mass index (BMI) in adolescents and young adults and risk for multiple sclerosis (MS) at the population level. We used data from the population-based compulsory Norwegian tuberculosis screening program during 1963 to 1975, includin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neurology 2021-12, Vol.97 (23), p.e2253-e2261
Hauptverfasser: Høglund, Rune A. Aa, Meyer, Haakon E., Stigum, Hein, Torkildsen, Øivind, Grytten, Nina, Holmøy, Trygve, Nakken, Ola
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page e2261
container_issue 23
container_start_page e2253
container_title Neurology
container_volume 97
creator Høglund, Rune A. Aa
Meyer, Haakon E.
Stigum, Hein
Torkildsen, Øivind
Grytten, Nina
Holmøy, Trygve
Nakken, Ola
description To prospectively investigate the long-term relationship between body mass index (BMI) in adolescents and young adults and risk for multiple sclerosis (MS) at the population level. We used data from the population-based compulsory Norwegian tuberculosis screening program during 1963 to 1975, including objectively measured height and weight from ≈85% of all eligible citizens. This was combined with data from the Norwegian MS registry and biobank up to November 2020. BMI was standardized according to age and sex, and risk for MS was calculated with Cox proportional hazard models. During 30,829,506 years of follow-up, we found 1,409 cases of MS among 648,734 participants in eligible age groups (14-34 years). Overall, obesity was associated with increased MS risk (hazard ratio [HR] 1.53 [95% confidence interval (CI) 1.25-1.88]), and the risk was similar in men (HR 1.4 [95% CI 0.95-2.06] and women (HR 1.59 [95% CI 1.25-2.02]). Risk was highest for the youngest age groups (age 14-16: HR 1.73 [95% CI 1.19-2.53]; 17-19: HR 1.61 [95% CI 1.08-2.39]; 20-24: HR 1.56 [95% CI 1.04-2.36]) and was no longer present for those >30 years of age. High BMI in individuals 14 to 24 years of age was associated with increased MS risk later in life in both male and female individuals.
doi_str_mv 10.1212/WNL.0000000000012957
format Article
fullrecord <record><control><sourceid>proquest_crist</sourceid><recordid>TN_cdi_cristin_nora_10852_90370</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2586453441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3064-2664e4f5e391ead2beea48ab83beabf88942151a33070264981d1b2de97052553</originalsourceid><addsrcrecordid>eNpdkV9PFDEUxRujkQX9Bkb7yMtA_0_Ht4WIkixiRKM-NZ3pHah023U6E9x3PzjdBSShL03uPfd3c89B6A0lB5RRdvjj8-KAPD7KGlk_QzMqmaoUZz-foxkhTFdc13oH7eb8u4gkq5uXaIcL1dRMyBn6N885dd6OPkWcenyU3Bqf2ZzxaXTwF_uI5y4FyB3EDrCNDv9KU7ws1SmMVym5bW2R4mU1wrDEX32-3oDOStuvAuCLLsCQss_v8Rx_SaspbJdVRzaDwxfj5Nav0Ivehgyv7_899P3kw7fjT9Xi_OPp8XxRdZwoUTGlBIheAm8oWMdaACu0bTVvwba91o1gVFLLOakJU6LR1NGWOWhqIpmUfA-9u-N2g8-jjyamwRpKtGSmIbwmRbF_p1gN6c8EeTRLX04PwUZIUzZMaiUkF4IWqXiApZwH6M1q8Es7rAvQbBIyJSHzNKEy9vZ-w9Quwf0feojkkXuTQnE0X4fpBgZzBbb4veUpSosZhFHKyqHVpiT4LXL5mcA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2586453441</pqid></control><display><type>article</type><title>Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study</title><source>NORA - Norwegian Open Research Archives</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Høglund, Rune A. Aa ; Meyer, Haakon E. ; Stigum, Hein ; Torkildsen, Øivind ; Grytten, Nina ; Holmøy, Trygve ; Nakken, Ola</creator><creatorcontrib>Høglund, Rune A. Aa ; Meyer, Haakon E. ; Stigum, Hein ; Torkildsen, Øivind ; Grytten, Nina ; Holmøy, Trygve ; Nakken, Ola</creatorcontrib><description>To prospectively investigate the long-term relationship between body mass index (BMI) in adolescents and young adults and risk for multiple sclerosis (MS) at the population level. We used data from the population-based compulsory Norwegian tuberculosis screening program during 1963 to 1975, including objectively measured height and weight from ≈85% of all eligible citizens. This was combined with data from the Norwegian MS registry and biobank up to November 2020. BMI was standardized according to age and sex, and risk for MS was calculated with Cox proportional hazard models. During 30,829,506 years of follow-up, we found 1,409 cases of MS among 648,734 participants in eligible age groups (14-34 years). Overall, obesity was associated with increased MS risk (hazard ratio [HR] 1.53 [95% confidence interval (CI) 1.25-1.88]), and the risk was similar in men (HR 1.4 [95% CI 0.95-2.06] and women (HR 1.59 [95% CI 1.25-2.02]). Risk was highest for the youngest age groups (age 14-16: HR 1.73 [95% CI 1.19-2.53]; 17-19: HR 1.61 [95% CI 1.08-2.39]; 20-24: HR 1.56 [95% CI 1.04-2.36]) and was no longer present for those &gt;30 years of age. High BMI in individuals 14 to 24 years of age was associated with increased MS risk later in life in both male and female individuals.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0000000000012957</identifier><identifier>PMID: 34697245</identifier><language>eng</language><publisher>United States: Lippincott Williams &amp; Wilkins</publisher><ispartof>Neurology, 2021-12, Vol.97 (23), p.e2253-e2261</ispartof><rights>Lippincott Williams &amp; Wilkins</rights><rights>2021 American Academy of Neurology.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3064-2664e4f5e391ead2beea48ab83beabf88942151a33070264981d1b2de97052553</citedby><cites>FETCH-LOGICAL-c3064-2664e4f5e391ead2beea48ab83beabf88942151a33070264981d1b2de97052553</cites><orcidid>0000-0003-4765-0636 ; 0000-0002-5801-3360 ; 0000-0001-5294-2866 ; 0000-0002-2098-1059 ; 0000-0002-7654-5897 ; 0000-0002-2529-5664</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,26567,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34697245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Høglund, Rune A. Aa</creatorcontrib><creatorcontrib>Meyer, Haakon E.</creatorcontrib><creatorcontrib>Stigum, Hein</creatorcontrib><creatorcontrib>Torkildsen, Øivind</creatorcontrib><creatorcontrib>Grytten, Nina</creatorcontrib><creatorcontrib>Holmøy, Trygve</creatorcontrib><creatorcontrib>Nakken, Ola</creatorcontrib><title>Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study</title><title>Neurology</title><addtitle>Neurology</addtitle><description>To prospectively investigate the long-term relationship between body mass index (BMI) in adolescents and young adults and risk for multiple sclerosis (MS) at the population level. We used data from the population-based compulsory Norwegian tuberculosis screening program during 1963 to 1975, including objectively measured height and weight from ≈85% of all eligible citizens. This was combined with data from the Norwegian MS registry and biobank up to November 2020. BMI was standardized according to age and sex, and risk for MS was calculated with Cox proportional hazard models. During 30,829,506 years of follow-up, we found 1,409 cases of MS among 648,734 participants in eligible age groups (14-34 years). Overall, obesity was associated with increased MS risk (hazard ratio [HR] 1.53 [95% confidence interval (CI) 1.25-1.88]), and the risk was similar in men (HR 1.4 [95% CI 0.95-2.06] and women (HR 1.59 [95% CI 1.25-2.02]). Risk was highest for the youngest age groups (age 14-16: HR 1.73 [95% CI 1.19-2.53]; 17-19: HR 1.61 [95% CI 1.08-2.39]; 20-24: HR 1.56 [95% CI 1.04-2.36]) and was no longer present for those &gt;30 years of age. High BMI in individuals 14 to 24 years of age was associated with increased MS risk later in life in both male and female individuals.</description><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNpdkV9PFDEUxRujkQX9Bkb7yMtA_0_Ht4WIkixiRKM-NZ3pHah023U6E9x3PzjdBSShL03uPfd3c89B6A0lB5RRdvjj8-KAPD7KGlk_QzMqmaoUZz-foxkhTFdc13oH7eb8u4gkq5uXaIcL1dRMyBn6N885dd6OPkWcenyU3Bqf2ZzxaXTwF_uI5y4FyB3EDrCNDv9KU7ws1SmMVym5bW2R4mU1wrDEX32-3oDOStuvAuCLLsCQss_v8Rx_SaspbJdVRzaDwxfj5Nav0Ivehgyv7_899P3kw7fjT9Xi_OPp8XxRdZwoUTGlBIheAm8oWMdaACu0bTVvwba91o1gVFLLOakJU6LR1NGWOWhqIpmUfA-9u-N2g8-jjyamwRpKtGSmIbwmRbF_p1gN6c8EeTRLX04PwUZIUzZMaiUkF4IWqXiApZwH6M1q8Es7rAvQbBIyJSHzNKEy9vZ-w9Quwf0feojkkXuTQnE0X4fpBgZzBbb4veUpSosZhFHKyqHVpiT4LXL5mcA</recordid><startdate>20211207</startdate><enddate>20211207</enddate><creator>Høglund, Rune A. Aa</creator><creator>Meyer, Haakon E.</creator><creator>Stigum, Hein</creator><creator>Torkildsen, Øivind</creator><creator>Grytten, Nina</creator><creator>Holmøy, Trygve</creator><creator>Nakken, Ola</creator><general>Lippincott Williams &amp; Wilkins</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><orcidid>https://orcid.org/0000-0003-4765-0636</orcidid><orcidid>https://orcid.org/0000-0002-5801-3360</orcidid><orcidid>https://orcid.org/0000-0001-5294-2866</orcidid><orcidid>https://orcid.org/0000-0002-2098-1059</orcidid><orcidid>https://orcid.org/0000-0002-7654-5897</orcidid><orcidid>https://orcid.org/0000-0002-2529-5664</orcidid></search><sort><creationdate>20211207</creationdate><title>Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study</title><author>Høglund, Rune A. Aa ; Meyer, Haakon E. ; Stigum, Hein ; Torkildsen, Øivind ; Grytten, Nina ; Holmøy, Trygve ; Nakken, Ola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3064-2664e4f5e391ead2beea48ab83beabf88942151a33070264981d1b2de97052553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Høglund, Rune A. Aa</creatorcontrib><creatorcontrib>Meyer, Haakon E.</creatorcontrib><creatorcontrib>Stigum, Hein</creatorcontrib><creatorcontrib>Torkildsen, Øivind</creatorcontrib><creatorcontrib>Grytten, Nina</creatorcontrib><creatorcontrib>Holmøy, Trygve</creatorcontrib><creatorcontrib>Nakken, Ola</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Høglund, Rune A. Aa</au><au>Meyer, Haakon E.</au><au>Stigum, Hein</au><au>Torkildsen, Øivind</au><au>Grytten, Nina</au><au>Holmøy, Trygve</au><au>Nakken, Ola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2021-12-07</date><risdate>2021</risdate><volume>97</volume><issue>23</issue><spage>e2253</spage><epage>e2261</epage><pages>e2253-e2261</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><abstract>To prospectively investigate the long-term relationship between body mass index (BMI) in adolescents and young adults and risk for multiple sclerosis (MS) at the population level. We used data from the population-based compulsory Norwegian tuberculosis screening program during 1963 to 1975, including objectively measured height and weight from ≈85% of all eligible citizens. This was combined with data from the Norwegian MS registry and biobank up to November 2020. BMI was standardized according to age and sex, and risk for MS was calculated with Cox proportional hazard models. During 30,829,506 years of follow-up, we found 1,409 cases of MS among 648,734 participants in eligible age groups (14-34 years). Overall, obesity was associated with increased MS risk (hazard ratio [HR] 1.53 [95% confidence interval (CI) 1.25-1.88]), and the risk was similar in men (HR 1.4 [95% CI 0.95-2.06] and women (HR 1.59 [95% CI 1.25-2.02]). Risk was highest for the youngest age groups (age 14-16: HR 1.73 [95% CI 1.19-2.53]; 17-19: HR 1.61 [95% CI 1.08-2.39]; 20-24: HR 1.56 [95% CI 1.04-2.36]) and was no longer present for those &gt;30 years of age. High BMI in individuals 14 to 24 years of age was associated with increased MS risk later in life in both male and female individuals.</abstract><cop>United States</cop><pub>Lippincott Williams &amp; Wilkins</pub><pmid>34697245</pmid><doi>10.1212/WNL.0000000000012957</doi><orcidid>https://orcid.org/0000-0003-4765-0636</orcidid><orcidid>https://orcid.org/0000-0002-5801-3360</orcidid><orcidid>https://orcid.org/0000-0001-5294-2866</orcidid><orcidid>https://orcid.org/0000-0002-2098-1059</orcidid><orcidid>https://orcid.org/0000-0002-7654-5897</orcidid><orcidid>https://orcid.org/0000-0002-2529-5664</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0028-3878
ispartof Neurology, 2021-12, Vol.97 (23), p.e2253-e2261
issn 0028-3878
1526-632X
language eng
recordid cdi_cristin_nora_10852_90370
source NORA - Norwegian Open Research Archives; Alma/SFX Local Collection; Journals@Ovid Complete
title Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T06%3A25%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_crist&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20Body%20Mass%20Index%20in%20Adolescence%20and%20Young%20Adulthood%20and%20Long-term%20Risk%20of%20Multiple%20Sclerosis:%20A%20Population-Based%20Study&rft.jtitle=Neurology&rft.au=H%C3%B8glund,%20Rune%20A.%20Aa&rft.date=2021-12-07&rft.volume=97&rft.issue=23&rft.spage=e2253&rft.epage=e2261&rft.pages=e2253-e2261&rft.issn=0028-3878&rft.eissn=1526-632X&rft_id=info:doi/10.1212/WNL.0000000000012957&rft_dat=%3Cproquest_crist%3E2586453441%3C/proquest_crist%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2586453441&rft_id=info:pmid/34697245&rfr_iscdi=true