Impact of Human Immunodeficiency Virus–Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Abstract Background We aimed to identify a human immunodeficiency virus (HIV)–related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbid conditions. Methods Bacterial 16S ribosomal RNA anal...
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| Veröffentlicht in: | Clinical infectious diseases 2020-11, Vol.71 (8), p.e359-e367 |
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| creator | Gelpi, Marco Vestad, Beate Hansen, Simen Hyll Holm, Kristian Drivsholm, Ninna Goetz, Alexandra Kirkby, Nicolai Søren Lindegaard, Birgitte Lebech, Anne-Mette Hoel, Hedda Michelsen, Annika E Ueland, Thor Gerstoft, Jan Lundgren, Jens Hov, Johannes Roksund Nielsen, Susanne Dam Trøseid, Marius |
| description | Abstract
Background
We aimed to identify a human immunodeficiency virus (HIV)–related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbid conditions.
Methods
Bacterial 16S ribosomal RNA analyses were performed on stool samples from 405 HIV-infected and 111 uninfected participants of the Copenhagen Comorbidity in HIV Infection (COCOMO) study. Individuals were stratified according to sexual behavior (men who have sex with men [MSM] vs non-MSM).
Results
After excluding MSM-associated microbiota traits and adjusting for confounders, we identified an HIV-related microbiota signature, consisting of lower biodiversity, increased relative abundance of the bacterial clades Gammaproteobacteria and Desulfovibrionaceae and decrease in several Clostridia. This microbiota profile was associated with a 2-fold excess risk of metabolic syndrome, driven by increase in Desulfovibrionaceae and decrease in Clostridia (Butyrivibrio, Coprococcus 2, Lachnospiraceae UCG-001 and CAG-56). This association was accentuated (5-fold excess risk) in individuals with previous severe immunodeficiency, which also modified the association between HIV-related microbiota signature and visceral adipose tissue (VAT) area (P for interaction = .01). Accordingly, HIV-related microbiota was associated with 30-cm2 larger VAT in individuals with history of severe immunodeficiency, but not in those without.
Conclusion
The HIV-related microbiota was associated with increased risk of metabolic syndrome and VAT accumulation, particularly in individuals with previous severe immunodeficiency, driven by increased Desulfovibrionaceae and lower abundance of several Clostridia. Our findings suggest a potential interplay between HIV-related microbiota, immune dysfunction and metabolic comorbid conditions. Interventions targeting the gut microbiome may be warranted to reduce cardiovascular risk, particularly in individuals with previous immunodeficiency.
Human immunodeficiency virus–related microbiota alterations were associated with visceral fat accumulation and metabolic comorbid conditions, particularly in individuals with previous severe immunodeficiency. |
| doi_str_mv | 10.1093/cid/ciz1235 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_crist</sourceid><recordid>TN_cdi_cristin_nora_10852_83120</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/cid/ciz1235</oup_id><sourcerecordid>2332082391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-be97eac212006ade36e9b9f290bcd415b30bfb9ee62f1b91669831a510713cdc3</originalsourceid><addsrcrecordid>eNp90T1rHDEQBmARYuKvVOkTVcEQ1tZIt3ur0hyxfWBjCHFaoY9ZUNiVLpK2cCr_B_9D_xLLvnPKFMNM8fAW8xLyCdgpMCnOrHd1_gIX7TtyAK1YNl0r4X29Wds3i170--Qw59-MAfSs_UD2BfRywRfsgIzraaNtoXGgV_OkA11P0xyiw8Fbj8He018-zfnp4fEHjrqgo5dzoTfepmh8LJqejwWTLj6GTGOgN1i0iaO3dBWnmIx39QjOv4JjsjfoMePH3T4idxfff66umuvby_Xq_LqxQsjSGJRL1JYDZ6zTDkWH0siBS2asW0BrBDODkYgdH8BI6DrZC9AtsCUI66w4Il-2uTb5XHxQISatgPUtV1VyVsXJVmxS_DNjLmry2eI46oBxzooLwVnPhYRKv72FxZwTDmqT_KTTfQ1ULwWoWoDaFVD1513wbCZ0_-zbxyv4ugVx3vw36RnVnY-b</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2332082391</pqid></control><display><type>article</type><title>Impact of Human Immunodeficiency Virus–Related Gut Microbiota Alterations on Metabolic Comorbid Conditions</title><source>MEDLINE</source><source>NORA - Norwegian Open Research Archives</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Gelpi, Marco ; Vestad, Beate ; Hansen, Simen Hyll ; Holm, Kristian ; Drivsholm, Ninna ; Goetz, Alexandra ; Kirkby, Nicolai Søren ; Lindegaard, Birgitte ; Lebech, Anne-Mette ; Hoel, Hedda ; Michelsen, Annika E ; Ueland, Thor ; Gerstoft, Jan ; Lundgren, Jens ; Hov, Johannes Roksund ; Nielsen, Susanne Dam ; Trøseid, Marius</creator><creatorcontrib>Gelpi, Marco ; Vestad, Beate ; Hansen, Simen Hyll ; Holm, Kristian ; Drivsholm, Ninna ; Goetz, Alexandra ; Kirkby, Nicolai Søren ; Lindegaard, Birgitte ; Lebech, Anne-Mette ; Hoel, Hedda ; Michelsen, Annika E ; Ueland, Thor ; Gerstoft, Jan ; Lundgren, Jens ; Hov, Johannes Roksund ; Nielsen, Susanne Dam ; Trøseid, Marius</creatorcontrib><description>Abstract
Background
We aimed to identify a human immunodeficiency virus (HIV)–related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbid conditions.
Methods
Bacterial 16S ribosomal RNA analyses were performed on stool samples from 405 HIV-infected and 111 uninfected participants of the Copenhagen Comorbidity in HIV Infection (COCOMO) study. Individuals were stratified according to sexual behavior (men who have sex with men [MSM] vs non-MSM).
Results
After excluding MSM-associated microbiota traits and adjusting for confounders, we identified an HIV-related microbiota signature, consisting of lower biodiversity, increased relative abundance of the bacterial clades Gammaproteobacteria and Desulfovibrionaceae and decrease in several Clostridia. This microbiota profile was associated with a 2-fold excess risk of metabolic syndrome, driven by increase in Desulfovibrionaceae and decrease in Clostridia (Butyrivibrio, Coprococcus 2, Lachnospiraceae UCG-001 and CAG-56). This association was accentuated (5-fold excess risk) in individuals with previous severe immunodeficiency, which also modified the association between HIV-related microbiota signature and visceral adipose tissue (VAT) area (P for interaction = .01). Accordingly, HIV-related microbiota was associated with 30-cm2 larger VAT in individuals with history of severe immunodeficiency, but not in those without.
Conclusion
The HIV-related microbiota was associated with increased risk of metabolic syndrome and VAT accumulation, particularly in individuals with previous severe immunodeficiency, driven by increased Desulfovibrionaceae and lower abundance of several Clostridia. Our findings suggest a potential interplay between HIV-related microbiota, immune dysfunction and metabolic comorbid conditions. Interventions targeting the gut microbiome may be warranted to reduce cardiovascular risk, particularly in individuals with previous immunodeficiency.
Human immunodeficiency virus–related microbiota alterations were associated with visceral fat accumulation and metabolic comorbid conditions, particularly in individuals with previous severe immunodeficiency.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciz1235</identifier><identifier>PMID: 31894240</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Dysbiosis ; Gastrointestinal Microbiome ; HIV - genetics ; HIV Infections - complications ; HIV Infections - epidemiology ; Homosexuality, Male ; Humans ; Male ; RNA, Ribosomal, 16S - genetics ; Sexual and Gender Minorities</subject><ispartof>Clinical infectious diseases, 2020-11, Vol.71 (8), p.e359-e367</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c339t-be97eac212006ade36e9b9f290bcd415b30bfb9ee62f1b91669831a510713cdc3</cites><orcidid>0000-0002-2730-4376 ; 0000-0001-8901-7850</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,26567,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31894240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gelpi, Marco</creatorcontrib><creatorcontrib>Vestad, Beate</creatorcontrib><creatorcontrib>Hansen, Simen Hyll</creatorcontrib><creatorcontrib>Holm, Kristian</creatorcontrib><creatorcontrib>Drivsholm, Ninna</creatorcontrib><creatorcontrib>Goetz, Alexandra</creatorcontrib><creatorcontrib>Kirkby, Nicolai Søren</creatorcontrib><creatorcontrib>Lindegaard, Birgitte</creatorcontrib><creatorcontrib>Lebech, Anne-Mette</creatorcontrib><creatorcontrib>Hoel, Hedda</creatorcontrib><creatorcontrib>Michelsen, Annika E</creatorcontrib><creatorcontrib>Ueland, Thor</creatorcontrib><creatorcontrib>Gerstoft, Jan</creatorcontrib><creatorcontrib>Lundgren, Jens</creatorcontrib><creatorcontrib>Hov, Johannes Roksund</creatorcontrib><creatorcontrib>Nielsen, Susanne Dam</creatorcontrib><creatorcontrib>Trøseid, Marius</creatorcontrib><title>Impact of Human Immunodeficiency Virus–Related Gut Microbiota Alterations on Metabolic Comorbid Conditions</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Background
We aimed to identify a human immunodeficiency virus (HIV)–related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbid conditions.
Methods
Bacterial 16S ribosomal RNA analyses were performed on stool samples from 405 HIV-infected and 111 uninfected participants of the Copenhagen Comorbidity in HIV Infection (COCOMO) study. Individuals were stratified according to sexual behavior (men who have sex with men [MSM] vs non-MSM).
Results
After excluding MSM-associated microbiota traits and adjusting for confounders, we identified an HIV-related microbiota signature, consisting of lower biodiversity, increased relative abundance of the bacterial clades Gammaproteobacteria and Desulfovibrionaceae and decrease in several Clostridia. This microbiota profile was associated with a 2-fold excess risk of metabolic syndrome, driven by increase in Desulfovibrionaceae and decrease in Clostridia (Butyrivibrio, Coprococcus 2, Lachnospiraceae UCG-001 and CAG-56). This association was accentuated (5-fold excess risk) in individuals with previous severe immunodeficiency, which also modified the association between HIV-related microbiota signature and visceral adipose tissue (VAT) area (P for interaction = .01). Accordingly, HIV-related microbiota was associated with 30-cm2 larger VAT in individuals with history of severe immunodeficiency, but not in those without.
Conclusion
The HIV-related microbiota was associated with increased risk of metabolic syndrome and VAT accumulation, particularly in individuals with previous severe immunodeficiency, driven by increased Desulfovibrionaceae and lower abundance of several Clostridia. Our findings suggest a potential interplay between HIV-related microbiota, immune dysfunction and metabolic comorbid conditions. Interventions targeting the gut microbiome may be warranted to reduce cardiovascular risk, particularly in individuals with previous immunodeficiency.
Human immunodeficiency virus–related microbiota alterations were associated with visceral fat accumulation and metabolic comorbid conditions, particularly in individuals with previous severe immunodeficiency.</description><subject>Dysbiosis</subject><subject>Gastrointestinal Microbiome</subject><subject>HIV - genetics</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>Homosexuality, Male</subject><subject>Humans</subject><subject>Male</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Sexual and Gender Minorities</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>3HK</sourceid><recordid>eNp90T1rHDEQBmARYuKvVOkTVcEQ1tZIt3ur0hyxfWBjCHFaoY9ZUNiVLpK2cCr_B_9D_xLLvnPKFMNM8fAW8xLyCdgpMCnOrHd1_gIX7TtyAK1YNl0r4X29Wds3i170--Qw59-MAfSs_UD2BfRywRfsgIzraaNtoXGgV_OkA11P0xyiw8Fbj8He018-zfnp4fEHjrqgo5dzoTfepmh8LJqejwWTLj6GTGOgN1i0iaO3dBWnmIx39QjOv4JjsjfoMePH3T4idxfff66umuvby_Xq_LqxQsjSGJRL1JYDZ6zTDkWH0siBS2asW0BrBDODkYgdH8BI6DrZC9AtsCUI66w4Il-2uTb5XHxQISatgPUtV1VyVsXJVmxS_DNjLmry2eI46oBxzooLwVnPhYRKv72FxZwTDmqT_KTTfQ1ULwWoWoDaFVD1513wbCZ0_-zbxyv4ugVx3vw36RnVnY-b</recordid><startdate>20201105</startdate><enddate>20201105</enddate><creator>Gelpi, Marco</creator><creator>Vestad, Beate</creator><creator>Hansen, Simen Hyll</creator><creator>Holm, Kristian</creator><creator>Drivsholm, Ninna</creator><creator>Goetz, Alexandra</creator><creator>Kirkby, Nicolai Søren</creator><creator>Lindegaard, Birgitte</creator><creator>Lebech, Anne-Mette</creator><creator>Hoel, Hedda</creator><creator>Michelsen, Annika E</creator><creator>Ueland, Thor</creator><creator>Gerstoft, Jan</creator><creator>Lundgren, Jens</creator><creator>Hov, Johannes Roksund</creator><creator>Nielsen, Susanne Dam</creator><creator>Trøseid, Marius</creator><general>Oxford University Press</general><general>University of Chicago Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><orcidid>https://orcid.org/0000-0002-2730-4376</orcidid><orcidid>https://orcid.org/0000-0001-8901-7850</orcidid></search><sort><creationdate>20201105</creationdate><title>Impact of Human Immunodeficiency Virus–Related Gut Microbiota Alterations on Metabolic Comorbid Conditions</title><author>Gelpi, Marco ; Vestad, Beate ; Hansen, Simen Hyll ; Holm, Kristian ; Drivsholm, Ninna ; Goetz, Alexandra ; Kirkby, Nicolai Søren ; Lindegaard, Birgitte ; Lebech, Anne-Mette ; Hoel, Hedda ; Michelsen, Annika E ; Ueland, Thor ; Gerstoft, Jan ; Lundgren, Jens ; Hov, Johannes Roksund ; Nielsen, Susanne Dam ; Trøseid, Marius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-be97eac212006ade36e9b9f290bcd415b30bfb9ee62f1b91669831a510713cdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Dysbiosis</topic><topic>Gastrointestinal Microbiome</topic><topic>HIV - genetics</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>Homosexuality, Male</topic><topic>Humans</topic><topic>Male</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Sexual and Gender Minorities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gelpi, Marco</creatorcontrib><creatorcontrib>Vestad, Beate</creatorcontrib><creatorcontrib>Hansen, Simen Hyll</creatorcontrib><creatorcontrib>Holm, Kristian</creatorcontrib><creatorcontrib>Drivsholm, Ninna</creatorcontrib><creatorcontrib>Goetz, Alexandra</creatorcontrib><creatorcontrib>Kirkby, Nicolai Søren</creatorcontrib><creatorcontrib>Lindegaard, Birgitte</creatorcontrib><creatorcontrib>Lebech, Anne-Mette</creatorcontrib><creatorcontrib>Hoel, Hedda</creatorcontrib><creatorcontrib>Michelsen, Annika E</creatorcontrib><creatorcontrib>Ueland, Thor</creatorcontrib><creatorcontrib>Gerstoft, Jan</creatorcontrib><creatorcontrib>Lundgren, Jens</creatorcontrib><creatorcontrib>Hov, Johannes Roksund</creatorcontrib><creatorcontrib>Nielsen, Susanne Dam</creatorcontrib><creatorcontrib>Trøseid, Marius</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gelpi, Marco</au><au>Vestad, Beate</au><au>Hansen, Simen Hyll</au><au>Holm, Kristian</au><au>Drivsholm, Ninna</au><au>Goetz, Alexandra</au><au>Kirkby, Nicolai Søren</au><au>Lindegaard, Birgitte</au><au>Lebech, Anne-Mette</au><au>Hoel, Hedda</au><au>Michelsen, Annika E</au><au>Ueland, Thor</au><au>Gerstoft, Jan</au><au>Lundgren, Jens</au><au>Hov, Johannes Roksund</au><au>Nielsen, Susanne Dam</au><au>Trøseid, Marius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Human Immunodeficiency Virus–Related Gut Microbiota Alterations on Metabolic Comorbid Conditions</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2020-11-05</date><risdate>2020</risdate><volume>71</volume><issue>8</issue><spage>e359</spage><epage>e367</epage><pages>e359-e367</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Abstract
Background
We aimed to identify a human immunodeficiency virus (HIV)–related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbid conditions.
Methods
Bacterial 16S ribosomal RNA analyses were performed on stool samples from 405 HIV-infected and 111 uninfected participants of the Copenhagen Comorbidity in HIV Infection (COCOMO) study. Individuals were stratified according to sexual behavior (men who have sex with men [MSM] vs non-MSM).
Results
After excluding MSM-associated microbiota traits and adjusting for confounders, we identified an HIV-related microbiota signature, consisting of lower biodiversity, increased relative abundance of the bacterial clades Gammaproteobacteria and Desulfovibrionaceae and decrease in several Clostridia. This microbiota profile was associated with a 2-fold excess risk of metabolic syndrome, driven by increase in Desulfovibrionaceae and decrease in Clostridia (Butyrivibrio, Coprococcus 2, Lachnospiraceae UCG-001 and CAG-56). This association was accentuated (5-fold excess risk) in individuals with previous severe immunodeficiency, which also modified the association between HIV-related microbiota signature and visceral adipose tissue (VAT) area (P for interaction = .01). Accordingly, HIV-related microbiota was associated with 30-cm2 larger VAT in individuals with history of severe immunodeficiency, but not in those without.
Conclusion
The HIV-related microbiota was associated with increased risk of metabolic syndrome and VAT accumulation, particularly in individuals with previous severe immunodeficiency, driven by increased Desulfovibrionaceae and lower abundance of several Clostridia. Our findings suggest a potential interplay between HIV-related microbiota, immune dysfunction and metabolic comorbid conditions. Interventions targeting the gut microbiome may be warranted to reduce cardiovascular risk, particularly in individuals with previous immunodeficiency.
Human immunodeficiency virus–related microbiota alterations were associated with visceral fat accumulation and metabolic comorbid conditions, particularly in individuals with previous severe immunodeficiency.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31894240</pmid><doi>10.1093/cid/ciz1235</doi><orcidid>https://orcid.org/0000-0002-2730-4376</orcidid><orcidid>https://orcid.org/0000-0001-8901-7850</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; NORA - Norwegian Open Research Archives; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Dysbiosis Gastrointestinal Microbiome HIV - genetics HIV Infections - complications HIV Infections - epidemiology Homosexuality, Male Humans Male RNA, Ribosomal, 16S - genetics Sexual and Gender Minorities |
| title | Impact of Human Immunodeficiency Virus–Related Gut Microbiota Alterations on Metabolic Comorbid Conditions |
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