Transport of nanoparticles across the endothelial cell layer

Transport of nanoparticles across the endothelial cell layer

•We here discuss how intravenously injected nanoparticles enter tumours and are taken up by tumour cells.•We discuss how nanoparticles can be transported across the endothelial cell layer.•More studies are required to conclude about the contribution of passive and energy dependant mechanisms for thi...

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Veröffentlicht in:Nano today 2021-02, Vol.36, p.101029, Article 101029
Hauptverfasser: Skotland, Tore, Sandvig, Kirsten
Format: Artikel
Sprache:eng
Schlagworte:
Biodistribution of nanoparticles
Electron microscopy
Endocytosis of nanoparticles
Enhanced Permeability and Retention Effect (EPR)
Transport of nanoparticles
Uptake across the endothelial cell layer
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description •We here discuss how intravenously injected nanoparticles enter tumours and are taken up by tumour cells.•We discuss how nanoparticles can be transported across the endothelial cell layer.•More studies are required to conclude about the contribution of passive and energy dependant mechanisms for this transport. Studies of how intravenously injected nanoparticles (NPs) enter tumours and are taken up by tumour cells have been discussed for more than three decades. Despite this, we still have much to learn about interactions between NPs and how they can be transported across the endothelial cell layer. More studies are required before firm conclusions can be drawn regarding the contribution of passive or energy dependent mechanisms for transport of NPs over the endothelial cells allowing the NPs to reach solid tumours.
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source NORA - Norwegian Open Research Archives; Elsevier ScienceDirect Journals Complete
subjects Biodistribution of nanoparticles
Electron microscopy
Endocytosis of nanoparticles
Enhanced Permeability and Retention Effect (EPR)
Transport of nanoparticles
Uptake across the endothelial cell layer
title Transport of nanoparticles across the endothelial cell layer
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