TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram‐positive bacteria

We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated blood was treated with selective inhibitors of TLR8 and/or complement C5, a...

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Veröffentlicht in:	Journal of leukocyte biology 2020-04, Vol.107 (4), p.673-683
Hauptverfasser:	Ehrnström, Birgitta, Kojen, June F., Giambelluca, Miriam, Ryan, Liv, Moen, Siv H., Hu, Zhenyi, Yin, Hang, Mollnes, Tom E., Damås, Jan K., Espevik, Terje, Stenvik, Jørgen
Format:	Artikel
Sprache:	eng
Schlagworte:	bacterial infection blood cytokines innate immunity phagocytes phagocytosis prothrombin
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