Shared and independent functions of aPKC[lambda] and Par3 in skin tumorigenesis

The polarity proteins Par3 and aPKC are key regulators of processes altered in cancer. Par3/aPKC are thought to dynamically interact with Par6 but increasing evidence suggests that aPKC and Par3 also exert complex-independent functions. Whereas aPKC[lambda] serves as tumor promotor, Par3 can either...

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Veröffentlicht in:	Oncogene 2018-09, Vol.37 (37), p.5136
Hauptverfasser:	Vorhagen, Susanne, Kleefisch, Dominik, Persa, Oana-Diana, Graband, Annika, Schwickert, Alexandra, Saynisch, Michael, Leitges, Michael
Format:	Artikel
Sprache:	eng ; nor
Schlagworte:	Carcinogenesis Care and treatment Development and progression Gene expression Genetic aspects Homeostasis Macrophages Proteins Skin Skin cancer Tumors
Online-Zugang:	Volltext
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