Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls

Background: Patients with celiac disease (CD), including adults with subclinical disease, have low bone mineral density (BMD), deteriorated bone microarchitecture and meta-analysis show an increased risk of fracture. Immunoglobulin A (IgA) against transglutaminase 2 (IgA TG2) is a highly reliable ma...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scandinavian journal of gastroenterology 2018-11, Vol.53 (10-11), p.1212-1216
Hauptverfasser: Hjelle, Anja M., Apalset, Ellen, Mielnik, Pawel, Nilsen, Roy M., Lundin, Knut E. A., Tell, Grethe S.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1216
container_issue 10-11
container_start_page 1212
container_title Scandinavian journal of gastroenterology
container_volume 53
creator Hjelle, Anja M.
Apalset, Ellen
Mielnik, Pawel
Nilsen, Roy M.
Lundin, Knut E. A.
Tell, Grethe S.
description Background: Patients with celiac disease (CD), including adults with subclinical disease, have low bone mineral density (BMD), deteriorated bone microarchitecture and meta-analysis show an increased risk of fracture. Immunoglobulin A (IgA) against transglutaminase 2 (IgA TG2) is a highly reliable marker to detect CD. Main objective: To explore the prevalence of positive IgA TG2 and CD in patients with distal radius and ankle fracture compared to community-based controls. Methods: Four hundred patients aged 40 years or above with distal fractures were included in a case-control study. About 197 controls were identified from the National Population Registry, those included had never suffered a fracture. BMD was measured, and comorbidities, medications, physical activity, smoking habits, body mass index (BMI) and nutritional factors were registered. Blood analysis to detect common causes of secondary osteoporosis was performed. Results: About 2.5% of the fracture patients had positive IgA TG2, compared to 1% in the control group. The odds ratio, adjusted for sex and age, of having positive IgA TG2 was 2.50 (95% CI 0.54-11.56). Conclusions: There were no significantly increased odds of CD in adult patients with fractures compared to controls; however, results imply that positive IgA TG2 is more prevalent in fracture patients than in controls. This study indicates that universal screening for CD in fracture patients is not warranted, but supports current clinical practice in Norway to suspect and investigate for CD in patients with fracture, osteoporosis and other risk factors for CD.
doi_str_mv 10.1080/00365521.2018.1509122
format Article
fullrecord <record><control><sourceid>proquest_3HK</sourceid><recordid>TN_cdi_cristin_nora_10852_67334</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2114699200</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-4fb25b66f79a73f081d0bf73b1ed8773f9b1915c8f2569ca43fc7dfce94d26c3</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhS0EotOBnwB4ySaDH3Gc7KgqKJUqwaJ768aPwZDYg-1QzYq_jqOZYcnC8r3Wd8-1zkHoDSU7SnrygRDeCcHojhHa76ggA2XsGdrUijVSkv452qxMs0JX6DrnH4QQIdvhJbrihHWCdnyD_nyL2Rf_2-L7_Q2GPfiQCy4JQt5PS4HZB8gWM-wDPkDxNpSMn3z5jo3PBSacwPglYwimnp-TxS6BLkuyGes4HyBZg0tc63kJvhybseqZ2oeS4pRfoRcOpmxfn-8tevz86fH2S_Pw9e7-9uah0S2XpWndyMTYdU4OILkjPTVkdJKP1Jpe1pdhpAMVundMdIOGljstjdN2aA3rNN-idydZneq3fVAhJlDVSMFUJzlvK_H-RBxS_LXYXNTss7bTBMHGJStGadsNA6uebpG4iMWck3XqkPwM6VgFV02iLuGoNRx1DqfOvT2vWMbZmn9TlzQq8PEE-OBimuEppsmoAscppmpr0D4r_v8dfwHtLJ8s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2114699200</pqid></control><display><type>article</type><title>Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls</title><source>NORA - Norwegian Open Research Archives</source><creator>Hjelle, Anja M. ; Apalset, Ellen ; Mielnik, Pawel ; Nilsen, Roy M. ; Lundin, Knut E. A. ; Tell, Grethe S.</creator><creatorcontrib>Hjelle, Anja M. ; Apalset, Ellen ; Mielnik, Pawel ; Nilsen, Roy M. ; Lundin, Knut E. A. ; Tell, Grethe S.</creatorcontrib><description>Background: Patients with celiac disease (CD), including adults with subclinical disease, have low bone mineral density (BMD), deteriorated bone microarchitecture and meta-analysis show an increased risk of fracture. Immunoglobulin A (IgA) against transglutaminase 2 (IgA TG2) is a highly reliable marker to detect CD. Main objective: To explore the prevalence of positive IgA TG2 and CD in patients with distal radius and ankle fracture compared to community-based controls. Methods: Four hundred patients aged 40 years or above with distal fractures were included in a case-control study. About 197 controls were identified from the National Population Registry, those included had never suffered a fracture. BMD was measured, and comorbidities, medications, physical activity, smoking habits, body mass index (BMI) and nutritional factors were registered. Blood analysis to detect common causes of secondary osteoporosis was performed. Results: About 2.5% of the fracture patients had positive IgA TG2, compared to 1% in the control group. The odds ratio, adjusted for sex and age, of having positive IgA TG2 was 2.50 (95% CI 0.54-11.56). Conclusions: There were no significantly increased odds of CD in adult patients with fractures compared to controls; however, results imply that positive IgA TG2 is more prevalent in fracture patients than in controls. This study indicates that universal screening for CD in fracture patients is not warranted, but supports current clinical practice in Norway to suspect and investigate for CD in patients with fracture, osteoporosis and other risk factors for CD.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365521.2018.1509122</identifier><identifier>PMID: 30265163</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>bone mineral density ; Celiac disease ; fracture ; IgA against transglutaminase 2 ; osteoporosis</subject><ispartof>Scandinavian journal of gastroenterology, 2018-11, Vol.53 (10-11), p.1212-1216</ispartof><rights>2018 Informa UK Limited, trading as Taylor &amp; Francis Group 2018</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-4fb25b66f79a73f081d0bf73b1ed8773f9b1915c8f2569ca43fc7dfce94d26c3</citedby><cites>FETCH-LOGICAL-c437t-4fb25b66f79a73f081d0bf73b1ed8773f9b1915c8f2569ca43fc7dfce94d26c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,26567</link.rule.ids><linktorsrc>$$Uhttp://hdl.handle.net/10852/67334$$EView_record_in_NORA$$FView_record_in_$$GNORA$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30265163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hjelle, Anja M.</creatorcontrib><creatorcontrib>Apalset, Ellen</creatorcontrib><creatorcontrib>Mielnik, Pawel</creatorcontrib><creatorcontrib>Nilsen, Roy M.</creatorcontrib><creatorcontrib>Lundin, Knut E. A.</creatorcontrib><creatorcontrib>Tell, Grethe S.</creatorcontrib><title>Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background: Patients with celiac disease (CD), including adults with subclinical disease, have low bone mineral density (BMD), deteriorated bone microarchitecture and meta-analysis show an increased risk of fracture. Immunoglobulin A (IgA) against transglutaminase 2 (IgA TG2) is a highly reliable marker to detect CD. Main objective: To explore the prevalence of positive IgA TG2 and CD in patients with distal radius and ankle fracture compared to community-based controls. Methods: Four hundred patients aged 40 years or above with distal fractures were included in a case-control study. About 197 controls were identified from the National Population Registry, those included had never suffered a fracture. BMD was measured, and comorbidities, medications, physical activity, smoking habits, body mass index (BMI) and nutritional factors were registered. Blood analysis to detect common causes of secondary osteoporosis was performed. Results: About 2.5% of the fracture patients had positive IgA TG2, compared to 1% in the control group. The odds ratio, adjusted for sex and age, of having positive IgA TG2 was 2.50 (95% CI 0.54-11.56). Conclusions: There were no significantly increased odds of CD in adult patients with fractures compared to controls; however, results imply that positive IgA TG2 is more prevalent in fracture patients than in controls. This study indicates that universal screening for CD in fracture patients is not warranted, but supports current clinical practice in Norway to suspect and investigate for CD in patients with fracture, osteoporosis and other risk factors for CD.</description><subject>bone mineral density</subject><subject>Celiac disease</subject><subject>fracture</subject><subject>IgA against transglutaminase 2</subject><subject>osteoporosis</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNp9kUtv1DAUhS0EotOBnwB4ySaDH3Gc7KgqKJUqwaJ768aPwZDYg-1QzYq_jqOZYcnC8r3Wd8-1zkHoDSU7SnrygRDeCcHojhHa76ggA2XsGdrUijVSkv452qxMs0JX6DrnH4QQIdvhJbrihHWCdnyD_nyL2Rf_2-L7_Q2GPfiQCy4JQt5PS4HZB8gWM-wDPkDxNpSMn3z5jo3PBSacwPglYwimnp-TxS6BLkuyGes4HyBZg0tc63kJvhybseqZ2oeS4pRfoRcOpmxfn-8tevz86fH2S_Pw9e7-9uah0S2XpWndyMTYdU4OILkjPTVkdJKP1Jpe1pdhpAMVundMdIOGljstjdN2aA3rNN-idydZneq3fVAhJlDVSMFUJzlvK_H-RBxS_LXYXNTss7bTBMHGJStGadsNA6uebpG4iMWck3XqkPwM6VgFV02iLuGoNRx1DqfOvT2vWMbZmn9TlzQq8PEE-OBimuEppsmoAscppmpr0D4r_v8dfwHtLJ8s</recordid><startdate>20181102</startdate><enddate>20181102</enddate><creator>Hjelle, Anja M.</creator><creator>Apalset, Ellen</creator><creator>Mielnik, Pawel</creator><creator>Nilsen, Roy M.</creator><creator>Lundin, Knut E. A.</creator><creator>Tell, Grethe S.</creator><general>Taylor &amp; Francis</general><general>Informa Healthcare</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope></search><sort><creationdate>20181102</creationdate><title>Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls</title><author>Hjelle, Anja M. ; Apalset, Ellen ; Mielnik, Pawel ; Nilsen, Roy M. ; Lundin, Knut E. A. ; Tell, Grethe S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-4fb25b66f79a73f081d0bf73b1ed8773f9b1915c8f2569ca43fc7dfce94d26c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>bone mineral density</topic><topic>Celiac disease</topic><topic>fracture</topic><topic>IgA against transglutaminase 2</topic><topic>osteoporosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hjelle, Anja M.</creatorcontrib><creatorcontrib>Apalset, Ellen</creatorcontrib><creatorcontrib>Mielnik, Pawel</creatorcontrib><creatorcontrib>Nilsen, Roy M.</creatorcontrib><creatorcontrib>Lundin, Knut E. A.</creatorcontrib><creatorcontrib>Tell, Grethe S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hjelle, Anja M.</au><au>Apalset, Ellen</au><au>Mielnik, Pawel</au><au>Nilsen, Roy M.</au><au>Lundin, Knut E. A.</au><au>Tell, Grethe S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2018-11-02</date><risdate>2018</risdate><volume>53</volume><issue>10-11</issue><spage>1212</spage><epage>1216</epage><pages>1212-1216</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><abstract>Background: Patients with celiac disease (CD), including adults with subclinical disease, have low bone mineral density (BMD), deteriorated bone microarchitecture and meta-analysis show an increased risk of fracture. Immunoglobulin A (IgA) against transglutaminase 2 (IgA TG2) is a highly reliable marker to detect CD. Main objective: To explore the prevalence of positive IgA TG2 and CD in patients with distal radius and ankle fracture compared to community-based controls. Methods: Four hundred patients aged 40 years or above with distal fractures were included in a case-control study. About 197 controls were identified from the National Population Registry, those included had never suffered a fracture. BMD was measured, and comorbidities, medications, physical activity, smoking habits, body mass index (BMI) and nutritional factors were registered. Blood analysis to detect common causes of secondary osteoporosis was performed. Results: About 2.5% of the fracture patients had positive IgA TG2, compared to 1% in the control group. The odds ratio, adjusted for sex and age, of having positive IgA TG2 was 2.50 (95% CI 0.54-11.56). Conclusions: There were no significantly increased odds of CD in adult patients with fractures compared to controls; however, results imply that positive IgA TG2 is more prevalent in fracture patients than in controls. This study indicates that universal screening for CD in fracture patients is not warranted, but supports current clinical practice in Norway to suspect and investigate for CD in patients with fracture, osteoporosis and other risk factors for CD.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>30265163</pmid><doi>10.1080/00365521.2018.1509122</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 0036-5521
ispartof Scandinavian journal of gastroenterology, 2018-11, Vol.53 (10-11), p.1212-1216
issn 0036-5521
1502-7708
language eng
recordid cdi_cristin_nora_10852_67334
source NORA - Norwegian Open Research Archives
subjects bone mineral density
Celiac disease
fracture
IgA against transglutaminase 2
osteoporosis
title Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T05%3A54%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_3HK&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Positive%20IgA%20against%20transglutaminase%202%20in%20patients%20with%20distal%20radius%20and%20ankle%20fractures%20compared%20to%20community-based%20controls&rft.jtitle=Scandinavian%20journal%20of%20gastroenterology&rft.au=Hjelle,%20Anja%20M.&rft.date=2018-11-02&rft.volume=53&rft.issue=10-11&rft.spage=1212&rft.epage=1216&rft.pages=1212-1216&rft.issn=0036-5521&rft.eissn=1502-7708&rft_id=info:doi/10.1080/00365521.2018.1509122&rft_dat=%3Cproquest_3HK%3E2114699200%3C/proquest_3HK%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2114699200&rft_id=info:pmid/30265163&rfr_iscdi=true