Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders
Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells and inflammatory factors. The aim of the present study was to assess levels of soluble c...
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| Veröffentlicht in: | Schizophrenia research 2024-05, Vol.267, p.223-229 |
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| creator | Varden Gjerde, Kristian Bartz-Johannessen, Christoffer Steen, Vidar Martin Andreassen, Ole A. Steen, Nils Eiel Ueland, Thor Lekva, Tove Rettenbacher, Maria Joa, Inge Reitan, Solveig Klæbo Johnsen, Erik Kroken, Rune Andreas |
| description | Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells and inflammatory factors. The aim of the present study was to assess levels of soluble cellular adhesion molecules, including intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, mucosal addressin cell adhesion molecule (MADCAM), junctional adhesion molecule (JAM-A) and neural cadherin (N-CAD) in patients with schizophrenia compared to healthy controls.
The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.
The total patient group showed significantly higher levels of ICAM-1 (p |
| doi_str_mv | 10.1016/j.schres.2024.03.029 |
| format | Article |
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The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.
The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.
In our study, patients with schizophrenia – including the drug-naïve – have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.</description><identifier>ISSN: 0920-9964</identifier><identifier>ISSN: 1573-2509</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2024.03.029</identifier><identifier>PMID: 38574562</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Antipsychotic Agents - pharmacology ; Antipsychotic Agents - therapeutic use ; Cell Adhesion Molecules - blood ; Cellular adhesion molecules ; Endothelial inflammation ; Female ; Humans ; Intercellular Adhesion Molecule-1 - blood ; Male ; Middle Aged ; Neuroinflammation ; Non-affective psychosis ; PANSS ; Schizophrenia - blood ; Schizophrenia - drug therapy ; Schizophrenia - metabolism ; Schizophrenia-spectrum disorders ; Vascular Cell Adhesion Molecule-1 - blood</subject><ispartof>Schizophrenia research, 2024-05, Vol.267, p.223-229</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c381t-96c89b9815cd2c34b60fd5183ff4994a1e6d9b6342671d731982e7c537f8e4183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2024.03.029$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,26567,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38574562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varden Gjerde, Kristian</creatorcontrib><creatorcontrib>Bartz-Johannessen, Christoffer</creatorcontrib><creatorcontrib>Steen, Vidar Martin</creatorcontrib><creatorcontrib>Andreassen, Ole A.</creatorcontrib><creatorcontrib>Steen, Nils Eiel</creatorcontrib><creatorcontrib>Ueland, Thor</creatorcontrib><creatorcontrib>Lekva, Tove</creatorcontrib><creatorcontrib>Rettenbacher, Maria</creatorcontrib><creatorcontrib>Joa, Inge</creatorcontrib><creatorcontrib>Reitan, Solveig Klæbo</creatorcontrib><creatorcontrib>Johnsen, Erik</creatorcontrib><creatorcontrib>Kroken, Rune Andreas</creatorcontrib><title>Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells and inflammatory factors. The aim of the present study was to assess levels of soluble cellular adhesion molecules, including intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, mucosal addressin cell adhesion molecule (MADCAM), junctional adhesion molecule (JAM-A) and neural cadherin (N-CAD) in patients with schizophrenia compared to healthy controls.
The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.
The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.
In our study, patients with schizophrenia – including the drug-naïve – have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.</description><subject>Adult</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Cellular adhesion molecules</subject><subject>Endothelial inflammation</subject><subject>Female</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroinflammation</subject><subject>Non-affective psychosis</subject><subject>PANSS</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - metabolism</subject><subject>Schizophrenia-spectrum disorders</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><issn>0920-9964</issn><issn>1573-2509</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>3HK</sourceid><recordid>eNp9kc1u1DAURi0EotPCGyDwspuk_kscb5DQqFCkSmxgbXnsG8ajJA52MlV5KR6iL8atpmXJypJ17nft8xHyjrOaM95eHeri9xlKLZhQNZM1E-YF2fBGy0o0zLwkG2YEq4xp1Rk5L-XAGOMN06_JmewarZpWbEjewjCsg8vUhT2UmCY6pgH8OkChcaIhrz-ryT38OQJ1U6BzhmNMaxnu6QghercAXrolwrQUeheXPcVnxd9pxrdN0VVlBr_kdaQhlpQD5PKGvOrdUODt03lBfny-_r69qW6_ffm6_XRbednxpTKt78zOdLzxQXipdi3rQ8M72ffKGOU4tMHsWqlEq3nQkptOgPaN1H0HCrkL8uGU63MsS5zslLKznDGprURBLRKXJ2LO6dcKZbFjLB6FuAnwj1YyTFdCG4moeg5LpWTo7Zzj6PI9BtrHPuzBnvqwj31YJi32gWPvnzasO_T1b-i5AAQ-ngBAE8cIGVPQpUe3GcXZkOL_N_wFPymfOg</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Varden Gjerde, Kristian</creator><creator>Bartz-Johannessen, Christoffer</creator><creator>Steen, Vidar Martin</creator><creator>Andreassen, Ole A.</creator><creator>Steen, Nils Eiel</creator><creator>Ueland, Thor</creator><creator>Lekva, Tove</creator><creator>Rettenbacher, Maria</creator><creator>Joa, Inge</creator><creator>Reitan, Solveig Klæbo</creator><creator>Johnsen, Erik</creator><creator>Kroken, Rune Andreas</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope></search><sort><creationdate>20240501</creationdate><title>Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders</title><author>Varden Gjerde, Kristian ; Bartz-Johannessen, Christoffer ; Steen, Vidar Martin ; Andreassen, Ole A. ; Steen, Nils Eiel ; Ueland, Thor ; Lekva, Tove ; Rettenbacher, Maria ; Joa, Inge ; Reitan, Solveig Klæbo ; Johnsen, Erik ; Kroken, Rune Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-96c89b9815cd2c34b60fd5183ff4994a1e6d9b6342671d731982e7c537f8e4183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Cellular adhesion molecules</topic><topic>Endothelial inflammation</topic><topic>Female</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroinflammation</topic><topic>Non-affective psychosis</topic><topic>PANSS</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - metabolism</topic><topic>Schizophrenia-spectrum disorders</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Varden Gjerde, Kristian</creatorcontrib><creatorcontrib>Bartz-Johannessen, Christoffer</creatorcontrib><creatorcontrib>Steen, Vidar Martin</creatorcontrib><creatorcontrib>Andreassen, Ole A.</creatorcontrib><creatorcontrib>Steen, Nils Eiel</creatorcontrib><creatorcontrib>Ueland, Thor</creatorcontrib><creatorcontrib>Lekva, Tove</creatorcontrib><creatorcontrib>Rettenbacher, Maria</creatorcontrib><creatorcontrib>Joa, Inge</creatorcontrib><creatorcontrib>Reitan, Solveig Klæbo</creatorcontrib><creatorcontrib>Johnsen, Erik</creatorcontrib><creatorcontrib>Kroken, Rune Andreas</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varden Gjerde, Kristian</au><au>Bartz-Johannessen, Christoffer</au><au>Steen, Vidar Martin</au><au>Andreassen, Ole A.</au><au>Steen, Nils Eiel</au><au>Ueland, Thor</au><au>Lekva, Tove</au><au>Rettenbacher, Maria</au><au>Joa, Inge</au><au>Reitan, Solveig Klæbo</au><au>Johnsen, Erik</au><au>Kroken, Rune Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>267</volume><spage>223</spage><epage>229</epage><pages>223-229</pages><issn>0920-9964</issn><issn>1573-2509</issn><eissn>1573-2509</eissn><abstract>Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells and inflammatory factors. The aim of the present study was to assess levels of soluble cellular adhesion molecules, including intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, mucosal addressin cell adhesion molecule (MADCAM), junctional adhesion molecule (JAM-A) and neural cadherin (N-CAD) in patients with schizophrenia compared to healthy controls.
The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.
The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.
In our study, patients with schizophrenia – including the drug-naïve – have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38574562</pmid><doi>10.1016/j.schres.2024.03.029</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Schizophrenia research, 2024-05, Vol.267, p.223-229 |
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| source | MEDLINE; NORA - Norwegian Open Research Archives; Access via ScienceDirect (Elsevier) |
| subjects | Adult Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Cell Adhesion Molecules - blood Cellular adhesion molecules Endothelial inflammation Female Humans Intercellular Adhesion Molecule-1 - blood Male Middle Aged Neuroinflammation Non-affective psychosis PANSS Schizophrenia - blood Schizophrenia - drug therapy Schizophrenia - metabolism Schizophrenia-spectrum disorders Vascular Cell Adhesion Molecule-1 - blood |
| title | Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders |
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