TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in promoting the establishment of a robust inflammatory r...

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Veröffentlicht in:	The Journal of cell biology 2023-02, Vol.222 (2), p.1
Hauptverfasser:	Zhou, Jianwen, Rasmussen, Nikoline Lander, Olsvik, Hallvard Lauritz, Akimov, Vyacheslav, Hu, Zehan, Evjen, Gry, Kaeser-Pebernard, Stéphanie, Sankar, Devanarayanan Siva, Roubaty, Carole, Verlhac, Pauline, van de Beek, Nicole, Reggiori, Fulvio, Abudu, Yakubu Princely, Blagoev, Blagoy, Lamark, Trond, Johansen, Terje, Dengjel, Jörn
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Degradation DNA-Binding Proteins - metabolism Gene expression HeLa Cells Humans Inflammation Inflammatory response Kinases Phosphorylation Polyinosinic:polycytidylic acid Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins TLR3 protein Toll-like receptors
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