Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia
Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the du...
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| Veröffentlicht in: | Atherosclerosis 2021-10, Vol.335, p.8-15 |
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| creator | Klevmoen, Marianne Bogsrud, Martin P. Retterstøl, Kjetil Svilaas, Tone Vesterbekkmo, Elisabeth K. Hovland, Anders Berge, Christ Roeters van Lennep, Jeanine Holven, Kirsten B. |
| description | Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH women.
A cross-sectional study using an anonymous online self-administered questionnaire was conducted. Women with FH were recruited through Lipid Clinics in Norway and Netherlands and national FH patient organizations.
102 women with FH (n = 70 Norwegian and n = 32 Dutch) were included in the analysis. Total length of pregnancy-related off-statin periods was estimated for 80 women where data were available, and was median (min-max) 2.3 (0–14.2) years. Lost statin treatment time was estimated for 67 women where data were available, and was median (min-max) 18 (0–100)% at mean (SD) age of 31 (4.3) years at last pregnancy. More women breastfed in Norway (83%) and for longer time [8.5 [1-42] months] compared to the Netherlands [63%, p = 0.03; 3.6 (0–14) months, p |
| doi_str_mv | 10.1016/j.atherosclerosis.2021.09.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_crist</sourceid><recordid>TN_cdi_cristin_nora_10037_23629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915021013198</els_id><sourcerecordid>2572935184</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-2faa0bab709eb0399f9b9e510957228a14706fdcddb1817594c34b1be2e926063</originalsourceid><addsrcrecordid>eNqNUT1vFDEQtRCROEJ-A26QaHYz9no_XFCgCJJIJ9FAbXm9szmfdu3D9hHdv2eOgyYVzUwx772ZeY-xDwJqAaK73de27DDF7JZz9bmWIEUNugZoXrGNGHpdCTWo12wDNKm0aOENe5vzHgBUL4YNO25jzjzOPBdbfOAloS0rhsJPaFPm0zH58MQPCZ-CDe7EbZj4SKBcZsTpzwyTj1PmxH6OROXPvuz4bFe_eLvw3YkAbhcXzIXOXHD19h27mu2S8eZvv2Y_vn75fvdQbb_dP9593lZOqbZUcrYWRjv2oHGERutZjxpbAbrtpRysUD108-SmaRSD6FutXKNGMaJELTvommv2_qLrks_0ngkxWSPInt7IppOaEB8viEOKP490oll9drgsNmA8ZiNpk25aMSiCfvonRp4lnM0h-dWmEwmacyBmb14EYs6BGNCGNhL__sJH-viXx2Sy8xgcuZjQFTNF_59KvwEUYZ_2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2572935184</pqid></control><display><type>article</type><title>Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia</title><source>NORA - Norwegian Open Research Archives</source><source>Elsevier ScienceDirect Journals</source><creator>Klevmoen, Marianne ; Bogsrud, Martin P. ; Retterstøl, Kjetil ; Svilaas, Tone ; Vesterbekkmo, Elisabeth K. ; Hovland, Anders ; Berge, Christ ; Roeters van Lennep, Jeanine ; Holven, Kirsten B.</creator><creatorcontrib>Klevmoen, Marianne ; Bogsrud, Martin P. ; Retterstøl, Kjetil ; Svilaas, Tone ; Vesterbekkmo, Elisabeth K. ; Hovland, Anders ; Berge, Christ ; Roeters van Lennep, Jeanine ; Holven, Kirsten B.</creatorcontrib><description>Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH women.
A cross-sectional study using an anonymous online self-administered questionnaire was conducted. Women with FH were recruited through Lipid Clinics in Norway and Netherlands and national FH patient organizations.
102 women with FH (n = 70 Norwegian and n = 32 Dutch) were included in the analysis. Total length of pregnancy-related off-statin periods was estimated for 80 women where data were available, and was median (min-max) 2.3 (0–14.2) years. Lost statin treatment time was estimated for 67 women where data were available, and was median (min-max) 18 (0–100)% at mean (SD) age of 31 (4.3) years at last pregnancy. More women breastfed in Norway (83%) and for longer time [8.5 [1-42] months] compared to the Netherlands [63%, p = 0.03; 3.6 (0–14) months, p < 0.001]. Eighty-six percent of the women reported need for more information on pregnancy and breastfeeding in relation to FH.
Young FH women lose years of treatment when discontinuing statins in relation to pregnancy and breastfeeding periods and should be closely followed up to minimize the duration of these off-statin periods. Whether these periods of interrupted treatment increase the cardiovascular risk in FH women needs to be further elucidated.
[Display omitted]
•Statins are contraindicated when planning of and during pregnancy and breastfeeding.•Little is known about duration of pregnancy-related off-statin periods in familial hypercholesterolemia (FH) women•Length of pregnancy-related off-statin periods was 2.3 y ranging from 0 to 14 y.•FH women seem to breastfeed to a lesser extent than the general population.•Young FH women should be closely followed up to minimize the off-statin time</description><identifier>ISSN: 0021-9150</identifier><identifier>ISSN: 1879-1484</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2021.09.003</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Breastfeeding ; Familial hypercholesterolemia ; Pregnancy ; Statin ; Women's health</subject><ispartof>Atherosclerosis, 2021-10, Vol.335, p.8-15</ispartof><rights>2021 The Authors</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-2faa0bab709eb0399f9b9e510957228a14706fdcddb1817594c34b1be2e926063</citedby><cites>FETCH-LOGICAL-c445t-2faa0bab709eb0399f9b9e510957228a14706fdcddb1817594c34b1be2e926063</cites><orcidid>0000-0003-0427-6066 ; 0000-0001-6870-9962 ; 0000-0002-2287-9779 ; 0000-0002-8674-9703</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2021.09.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3536,26546,27903,27904,45974</link.rule.ids></links><search><creatorcontrib>Klevmoen, Marianne</creatorcontrib><creatorcontrib>Bogsrud, Martin P.</creatorcontrib><creatorcontrib>Retterstøl, Kjetil</creatorcontrib><creatorcontrib>Svilaas, Tone</creatorcontrib><creatorcontrib>Vesterbekkmo, Elisabeth K.</creatorcontrib><creatorcontrib>Hovland, Anders</creatorcontrib><creatorcontrib>Berge, Christ</creatorcontrib><creatorcontrib>Roeters van Lennep, Jeanine</creatorcontrib><creatorcontrib>Holven, Kirsten B.</creatorcontrib><title>Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia</title><title>Atherosclerosis</title><description>Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH women.
A cross-sectional study using an anonymous online self-administered questionnaire was conducted. Women with FH were recruited through Lipid Clinics in Norway and Netherlands and national FH patient organizations.
102 women with FH (n = 70 Norwegian and n = 32 Dutch) were included in the analysis. Total length of pregnancy-related off-statin periods was estimated for 80 women where data were available, and was median (min-max) 2.3 (0–14.2) years. Lost statin treatment time was estimated for 67 women where data were available, and was median (min-max) 18 (0–100)% at mean (SD) age of 31 (4.3) years at last pregnancy. More women breastfed in Norway (83%) and for longer time [8.5 [1-42] months] compared to the Netherlands [63%, p = 0.03; 3.6 (0–14) months, p < 0.001]. Eighty-six percent of the women reported need for more information on pregnancy and breastfeeding in relation to FH.
Young FH women lose years of treatment when discontinuing statins in relation to pregnancy and breastfeeding periods and should be closely followed up to minimize the duration of these off-statin periods. Whether these periods of interrupted treatment increase the cardiovascular risk in FH women needs to be further elucidated.
[Display omitted]
•Statins are contraindicated when planning of and during pregnancy and breastfeeding.•Little is known about duration of pregnancy-related off-statin periods in familial hypercholesterolemia (FH) women•Length of pregnancy-related off-statin periods was 2.3 y ranging from 0 to 14 y.•FH women seem to breastfeed to a lesser extent than the general population.•Young FH women should be closely followed up to minimize the off-statin time</description><subject>Breastfeeding</subject><subject>Familial hypercholesterolemia</subject><subject>Pregnancy</subject><subject>Statin</subject><subject>Women's health</subject><issn>0021-9150</issn><issn>1879-1484</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNUT1vFDEQtRCROEJ-A26QaHYz9no_XFCgCJJIJ9FAbXm9szmfdu3D9hHdv2eOgyYVzUwx772ZeY-xDwJqAaK73de27DDF7JZz9bmWIEUNugZoXrGNGHpdCTWo12wDNKm0aOENe5vzHgBUL4YNO25jzjzOPBdbfOAloS0rhsJPaFPm0zH58MQPCZ-CDe7EbZj4SKBcZsTpzwyTj1PmxH6OROXPvuz4bFe_eLvw3YkAbhcXzIXOXHD19h27mu2S8eZvv2Y_vn75fvdQbb_dP9593lZOqbZUcrYWRjv2oHGERutZjxpbAbrtpRysUD108-SmaRSD6FutXKNGMaJELTvommv2_qLrks_0ngkxWSPInt7IppOaEB8viEOKP490oll9drgsNmA8ZiNpk25aMSiCfvonRp4lnM0h-dWmEwmacyBmb14EYs6BGNCGNhL__sJH-viXx2Sy8xgcuZjQFTNF_59KvwEUYZ_2</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Klevmoen, Marianne</creator><creator>Bogsrud, Martin P.</creator><creator>Retterstøl, Kjetil</creator><creator>Svilaas, Tone</creator><creator>Vesterbekkmo, Elisabeth K.</creator><creator>Hovland, Anders</creator><creator>Berge, Christ</creator><creator>Roeters van Lennep, Jeanine</creator><creator>Holven, Kirsten B.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><orcidid>https://orcid.org/0000-0003-0427-6066</orcidid><orcidid>https://orcid.org/0000-0001-6870-9962</orcidid><orcidid>https://orcid.org/0000-0002-2287-9779</orcidid><orcidid>https://orcid.org/0000-0002-8674-9703</orcidid></search><sort><creationdate>20211001</creationdate><title>Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia</title><author>Klevmoen, Marianne ; Bogsrud, Martin P. ; Retterstøl, Kjetil ; Svilaas, Tone ; Vesterbekkmo, Elisabeth K. ; Hovland, Anders ; Berge, Christ ; Roeters van Lennep, Jeanine ; Holven, Kirsten B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-2faa0bab709eb0399f9b9e510957228a14706fdcddb1817594c34b1be2e926063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Breastfeeding</topic><topic>Familial hypercholesterolemia</topic><topic>Pregnancy</topic><topic>Statin</topic><topic>Women's health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klevmoen, Marianne</creatorcontrib><creatorcontrib>Bogsrud, Martin P.</creatorcontrib><creatorcontrib>Retterstøl, Kjetil</creatorcontrib><creatorcontrib>Svilaas, Tone</creatorcontrib><creatorcontrib>Vesterbekkmo, Elisabeth K.</creatorcontrib><creatorcontrib>Hovland, Anders</creatorcontrib><creatorcontrib>Berge, Christ</creatorcontrib><creatorcontrib>Roeters van Lennep, Jeanine</creatorcontrib><creatorcontrib>Holven, Kirsten B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klevmoen, Marianne</au><au>Bogsrud, Martin P.</au><au>Retterstøl, Kjetil</au><au>Svilaas, Tone</au><au>Vesterbekkmo, Elisabeth K.</au><au>Hovland, Anders</au><au>Berge, Christ</au><au>Roeters van Lennep, Jeanine</au><au>Holven, Kirsten B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia</atitle><jtitle>Atherosclerosis</jtitle><date>2021-10-01</date><risdate>2021</risdate><volume>335</volume><spage>8</spage><epage>15</epage><pages>8-15</pages><issn>0021-9150</issn><issn>1879-1484</issn><eissn>1879-1484</eissn><abstract>Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH women.
A cross-sectional study using an anonymous online self-administered questionnaire was conducted. Women with FH were recruited through Lipid Clinics in Norway and Netherlands and national FH patient organizations.
102 women with FH (n = 70 Norwegian and n = 32 Dutch) were included in the analysis. Total length of pregnancy-related off-statin periods was estimated for 80 women where data were available, and was median (min-max) 2.3 (0–14.2) years. Lost statin treatment time was estimated for 67 women where data were available, and was median (min-max) 18 (0–100)% at mean (SD) age of 31 (4.3) years at last pregnancy. More women breastfed in Norway (83%) and for longer time [8.5 [1-42] months] compared to the Netherlands [63%, p = 0.03; 3.6 (0–14) months, p < 0.001]. Eighty-six percent of the women reported need for more information on pregnancy and breastfeeding in relation to FH.
Young FH women lose years of treatment when discontinuing statins in relation to pregnancy and breastfeeding periods and should be closely followed up to minimize the duration of these off-statin periods. Whether these periods of interrupted treatment increase the cardiovascular risk in FH women needs to be further elucidated.
[Display omitted]
•Statins are contraindicated when planning of and during pregnancy and breastfeeding.•Little is known about duration of pregnancy-related off-statin periods in familial hypercholesterolemia (FH) women•Length of pregnancy-related off-statin periods was 2.3 y ranging from 0 to 14 y.•FH women seem to breastfeed to a lesser extent than the general population.•Young FH women should be closely followed up to minimize the off-statin time</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.atherosclerosis.2021.09.003</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0427-6066</orcidid><orcidid>https://orcid.org/0000-0001-6870-9962</orcidid><orcidid>https://orcid.org/0000-0002-2287-9779</orcidid><orcidid>https://orcid.org/0000-0002-8674-9703</orcidid><oa>free_for_read</oa></addata></record> |
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| source | NORA - Norwegian Open Research Archives; Elsevier ScienceDirect Journals |
| subjects | Breastfeeding Familial hypercholesterolemia Pregnancy Statin Women's health |
| title | Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia |
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