Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates

We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These N,N′-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold with two catio...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-08, Vol.64 (15), p.11395-11417
Hauptverfasser:	Paulsen, Marianne H, Engqvist, Magnus, Ausbacher, Dominik, Anderssen, Trude, Langer, Manuel K, Haug, Tor, Morello, Glenn R, Liikanen, Laura E, Blencke, Hans-Matti, Isaksson, Johan, Juskewitz, Eric, Bayer, Annette, Strøm, Morten B
Format:	Artikel
Sprache:	eng
Schlagworte:	Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary science disciplines: 710 Farmakologi: 728 Medical disciplines: 700 Medisinske Fag: 700 Pharmacology: 728 VDP
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