Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14

•Blocking C5aR1 and CD14 reduced phagocytosis and cytokine release in response to S. aureus and E. coli over time in blood.•The effect ofPMX-53 was potentiated by combined CD14 inhibition.•C5aR1 and CD14 seem attractive targets for inhibition of phagocytosis-induced inflammation induced by S. aureus...

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Veröffentlicht in:	Molecular immunology 2019-08, Vol.112, p.131-139
Hauptverfasser:	Skjeflo, E.W., Christiansen, D., Landsem, A., Stenvik, J., Woodruff, T.M., Espevik, T., Nielsen, E.W., Mollnes, T.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteremia Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary science disciplines: 710 Complement Inflammation Innate immune response Medical disciplines: 700 Medisinske Fag: 700 Phagocytosis Toll-like receptors VDP
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